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Preparation method for nano-silver anti-bacterial soluble gauze not loaded with silver chloride

A nano-silver antibacterial and silver chloride technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of silver consumption, waste, and reduced safety of soluble gauze, and achieve high safety in use and gelation Good, strong antibacterial and anti-infection effects

Active Publication Date: 2015-09-23
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Insoluble nano-silver chloride or silver chloride exists and adheres to the soluble gauze. After entering the human body, it will reduce the safety of the soluble gauze used in the body; moreover, the generation of this pollutant will consume part of the silver, That's a waste of precious metal silver

Method used

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  • Preparation method for nano-silver anti-bacterial soluble gauze not loaded with silver chloride
  • Preparation method for nano-silver anti-bacterial soluble gauze not loaded with silver chloride
  • Preparation method for nano-silver anti-bacterial soluble gauze not loaded with silver chloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] (1) Immerse 100 grams of etherified soluble gauze in 300 mL of ethanol solution containing 7.5% polyvinylpyrrolidone, react at room temperature for 30 minutes, then add 20 mL of silver ammonia solution with pH=9.8, and continue the reaction for 20 minutes;

[0051] (2) Add a sufficient amount of 12% ascorbic acid ethanol solution dropwise, react at room temperature for 60 minutes, after the dropwise addition is complete, raise the temperature to 45 degrees, react at a constant temperature for 45 minutes, and finally use sodium chloride to test that the precipitation of silver ions is complete.

[0052] (3) Cleaning with 78% ethanol aqueous solution and drying at 70° C. to obtain nano-silver antibacterial soluble gauze without silver chloride loading.

[0053] After testing, the obtained product is water-soluble and can be formed into a gel, and the antibacterial rate against Escherichia coli and Staphylococcus aureus within 24 hours is greater than 99.99%.

Embodiment 2

[0055] (1) Immerse 100 grams of etherified soluble gauze in 300 mL of ethanol solution containing 5% polyvinylpyrrolidone, react at room temperature for 20 minutes, then add 20 mL of silver ammonia solution with pH=8, and continue the reaction for 20 minutes;

[0056] (2) Add a sufficient amount of 10% ascorbic acid ethanol solution dropwise, react at room temperature for 50 minutes, after the dropwise addition is complete, raise the temperature to 45 degrees, react at a constant temperature for 45 minutes, and finally use sodium chloride to test that the precipitation of silver ions is complete.

[0057] (3) Washing with 78% ethanol aqueous solution and drying at 60° C. to obtain nano-silver antibacterial soluble gauze without silver chloride loading.

[0058] After testing, the obtained product is water-soluble and can be formed into a gel, and the antibacterial rate against Escherichia coli and Staphylococcus aureus within 24 hours is greater than 98.51%.

Embodiment 3

[0060] (1) Immerse 100 grams of etherified soluble gauze in 300 mL of ethanol solution containing 10% polyvinylpyrrolidone, react at room temperature for 40 minutes, then add 20 mL of silver ammonia solution with pH=11, and continue the reaction for 20 minutes;

[0061] (2) Add a sufficient amount of 15% ascorbic acid ethanol solution dropwise, react at room temperature for 70 minutes, after the dropwise addition is complete, raise the temperature to 45°C, react at a constant temperature for 45 minutes, and finally use sodium chloride to check that the precipitation of silver ions is complete.

[0062] (3) Cleaning with 78% ethanol aqueous solution and drying at 85° C. to obtain nano-silver antibacterial soluble gauze without silver chloride loading.

[0063] After testing, the obtained product is water-soluble and can be formed into a gel, and the antibacterial rate against Escherichia coli and Staphylococcus aureus within 24 hours is greater than 95.63%.

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Abstract

The invention discloses a preparation method for nano-silver anti-bacterial soluble gauze not loaded with silver chloride. The preparation method mainly comprises the following steps: immersing soluble gauze subjected to etherification into an ethanol solution of polyvinylpyrrolidone, then, adding excess silver-ammonia solution with the pH value of 8-11, and further reacting for 20 min; at the room temperature, dropwise adding an enough amount of an ethanol solution of ascorbic acid while stirring, and reacting for 50-70 min; reacting for 30-60 min at the constant temperature of 45 DEG C; taking out the gauze, washing the gauze with an ethanol aqueous solution, and drying at the temperature of 60-85 DEG C, so as to obtain the final product. Compared with the prior art, the preparation method has the advantages that the preparation technology is simple, no pollutants are generated or discharged during the production process, and the technology is green and environment-friendly; the prepared nano-silver anti-bacterial soluble gauze not loaded with silver chloride is excellent in water-soluble property and gel formation property, is good in anti-bacterial and infection-preventing property by virtue of loaded nano-silver, and is higher in safety as silver chloride is not loaded, thereby being more suitable for medical dressing and the like.

Description

technical field [0001] The invention relates to a preparation method of nano-silver antibacterial soluble gauze, in particular to a preparation method of nano-silver antibacterial soluble gauze without silver chloride loading. Background technique [0002] Medical dressings can be divided into traditional, natural and synthetic dressings according to the dressing materials. [0003] Among them, the traditional dressing mainly includes ordinary cotton gauze, bandage, etc., and the advantage of this type of dressing is that the production cost is low. However, its water absorption performance is poor, and it can adhere to the wound, and the wound is prone to secondary damage when the gauze is removed; [0004] Natural dressings mainly include chitosan dressings, alginate dressings and collagen dressings. Among them, chitosan can activate the body system, mediate a series of biological effects of the body system, improve the system function of phagocytic cells, and have antib...

Claims

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Application Information

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IPC IPC(8): A61L15/18A61L15/42A61L15/44A61L15/62
Inventor 李群薛云赵昔慧李子超王力平朱善富孙小璐付文华
Owner QINGDAO UNIV
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