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Capsule comprising docusate sodium and dantron and preparation method of capsule

A technology of docusate sodium and capsules, which is applied in the field of capsules containing docusate sodium and danthraquinone and its preparation, and can solve the problems of providing raw materials, lack of high purity, and difficulty in having no drugs, etc.

Active Publication Date: 2015-09-30
哈尔滨瀚钧现代制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no drug in the form of docusate sodium danthrone composition on the market now, because there is no pharmaceutically acceptable danthrone raw material on the market, no high-purity docusate sodium, and The unique physical properties of docusate sodium (viscous wax) determine that it is difficult to make solid preparations such as granules, capsules, tablets, etc. There is no raw material drug that can be provided for this combination drug

Method used

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  • Capsule comprising docusate sodium and dantron and preparation method of capsule
  • Capsule comprising docusate sodium and dantron and preparation method of capsule
  • Capsule comprising docusate sodium and dantron and preparation method of capsule

Examples

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Effect test

Embodiment 1

[0078] Embodiment 1, a kind of capsule (100000 grains, specification is 330mg / grain) containing docusate sodium and danthraquinone

[0079] Docusate sodium 6.0kg, danthraquinone 2.5kg, starch 24.3kg, sodium benzoate 0.2kg.

[0080] The capsules are made by the following method:

[0081] Mix docusate sodium and starch at a weight ratio of 1:1, stir, then mix docusate sodium and starch at a weight ratio of 1:1, stir, and mix again with docusate sodium and starch at a ratio of 1:1 for the third time , stirred, and passed through a 80-mesh sieve to obtain fine particles after mixing docusate sodium and starch; mix danthrone and the remaining amount of starch evenly, and pass through an 80-mesh sieve; mix docusate sodium starch mixture and danthraquinone starch mixture Mix, add sodium benzoate and 98% ethanol, mix and granulate in a granulator, dry at 45° C., granulate, and fill capsules; taking danthraquinone as 1 g, the amount of ethanol for granulation is 0.9 ml.

Embodiment 2

[0082] Embodiment 2, a kind of capsule (100000 grains, specification is 330mg / grain) containing docusate sodium and danthraquinone

[0083] Docusate sodium 6.0kg, danthraquinone 2.5kg, starch 22kg, sodium benzoate 0.125kg.

[0084] The preparation method of this capsule is with reference to the method for embodiment 1.

Embodiment 3

[0085] Embodiment 3, a kind of capsule (100000 grains, specification is 330mg / grain) containing docusate sodium and danthraquinone

[0086] Docusate sodium 6.0kg, danthraquinone 2.5kg, starch 26kg, sodium benzoate 0.25kg.

[0087] The preparation method of this capsule is with reference to the method for embodiment 1.

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Abstract

The invention provides a capsule comprising docusate sodium and dantron, a preparation method of the capsule, docusate sodium used as one of the raw material medicines of the capsule, and a technological method for synthesizing medicinal-level high-purity docusate sodium. The prepared product has the effects of treating constipation and reducing the side effects of a cathartic.

Description

technical field [0001] The invention relates to a capsule containing docusate sodium and danthraquinone and a preparation method thereof, in particular to a capsule containing docusate sodium and danthraquinone, which is composed of a laxative composition composed of raw materials improved through a synthesis process. The capsule of the present invention selectively delivers the pharmaceutically high-purity drug to the digestive system, improves the effect and safety, and reduces side effects. Background technique [0002] Laxatives are divided into bulking laxatives, saline laxatives, or prokinetic laxatives (stoolsoftner) and stimulant laxatives. Salt laxatives include magnesium oxide, heavy magnesium oxide, magnesium hydroxide, magnesium carbonate, and magnesium sulfate; bulking laxatives are mainly fibers, such as sodium carboxymethylcellulose and calcium carboxymethylcellulose; prokinetic laxatives are also Known as stool softeners, docusate sodium, surfak, prosham, et...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/22A61K31/122A61K47/36C07C50/16C07C46/00C07C303/02C07C309/17A61P1/10
Inventor 李细海
Owner 哈尔滨瀚钧现代制药有限公司
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