Synthesis method and application of molecularly imprinted mesoporous material

A mesoporous material and molecular imprinting technology, applied in chemical instruments and methods, and other chemical processes, can solve the problems of cumbersome steps and limited applicability, and achieve the effects of wide application prospects, excellent performance, and high imprinting efficiency

Inactive Publication Date: 2015-09-30
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the cumbersome steps and limited applicability of the current method for preparing molecularly imprinted mesoporous mate

Method used

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  • Synthesis method and application of molecularly imprinted mesoporous material
  • Synthesis method and application of molecularly imprinted mesoporous material
  • Synthesis method and application of molecularly imprinted mesoporous material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Synthesis of triethoxysilane modified with aminophenylboronic acid

[0030] Synthetic steps see figure 2 , specifically: add 10mmol glycidyl etheroxypropyltriethoxyoxysilane and 10mmol m-aminophenylboronic acid to a 25mL round bottom flask, vacuumize the flask and fill it with nitrogen, inject 15mL tetrahydrofuran, and then Stir at room temperature under protection for 12 hours. After evaporating the solvent, the obtained oily liquid was redissolved with 10 mL of methanol to obtain a 1 mmol / mL solution S-1, namely a solution of triethoxysilane modified with aminophenylboronic acid.

Embodiment 2

[0031] Example 2: Preparation of crude product of molecularly imprinted mesoporous material

[0032] First, add 0.6g of cetyltrimethylammonium bromide, 168mg of sodium hydroxide, and 288mL of water into a 500mL round bottom flask to obtain a mixture, then heat the above mixture to 80°C with stirring, then add 69.4mg of monophosphoric acid Adenosine (AMP) was stirred for 15 minutes until the solution was clear. Then, under vigorous stirring, the prepolymer solution was added dropwise to the above clear solution, kept at 80° C. for 2 hours, and then filtered to obtain the crude product. The above-mentioned pre-polymerization liquid is prepared by mixing 9.8 mmol orthoethyl silicate, 0.2 mmol 3-aminopropyltriethoxysilane, and 0.2 mmol solution S-1.

[0033] The above-mentioned anionic surfactant cetyltrimethylammonium bromide can be replaced by sodium lauryl sulfate (0.57g) of an equimolar amount, and all the other steps remain unchanged.

[0034] The above imprinting template ...

Embodiment 3

[0037] Embodiment 3: the removal of template

[0038] The removal of the template in this embodiment includes both the removal of the mesoporous template and the removal of the imprinted template. The removal of the above two template molecules is simultaneous. Specifically, the Soxhlet extraction method is used to remove the template under acidic conditions. The acidic condition is the acidic extraction solution. The acidic extraction solution is prepared by dissolving 1.5mL of hydrochloric acid with a mass concentration of 37.2% in 150mL of methanol solution, and the extraction time is 24 hours. . After the extraction, the obtained material was vacuum-dried at 60° C. for 12 hours; the molecularly imprinted mesoporous material was obtained.

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Abstract

The invention discloses a synthesis method of a molecularly imprinted mesoporous material. The method comprises the following steps: assembling an imprinted template molecule onto the surface of a mesoporous template in a solution, polymerizing an auto-polymerizable compound in the solution to form a mesoporous material, and finally, removing the template under acidic conditions to form the mesoporous ducts and imprinted cavities, thereby obtaining the molecularly imprinted mesoporous material. The method can efficiently and conveniently remove the template in the imprinted material; and all the obtained imprinted cavities are distributed on the internal surface of the mesoporous ducts, and thus, the molecularly imprinted mesoporous material has excellent accessibility. The obtained material has favorable selectivity and excellent antijamming ability for the target molecule when being used in complex biological samples. The double-template docking technique in the invention is also applicable to synthesis of other pore-system-based porous imprinted materials, and has wide application prospects in the field of functional materials and preparation and synthesis thereof.

Description

technical field [0001] The invention belongs to the field of molecularly imprinted functionalized materials, and specifically relates to the construction of double template docking, directional molecular imprinting technology and the preparation of molecularly imprinted mesoporous materials, as well as its specific recognition, separation and purification of template molecules in complex samples. Background technique [0002] Mesoporous materials are a brand-new class of porous materials developed by Beck, a researcher of Mobil Corporation, in the early 1990s [C.T. The pore arrangement is highly ordered and the pore size is uniform, and at the same time, it can be continuously adjusted from one dimension to three dimensions on the nanometer scale, and has a relatively large surface area and pore volume. These properties make them incomparably superior and have broad application prospects in the fields of catalysis, sensing and separation. [0003] Molecular imprinting techn...

Claims

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Application Information

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IPC IPC(8): C08J9/26C08G77/56C08G77/26B01J20/285
Inventor 刘震陈阳李星霖
Owner NANJING UNIV
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