Method for preparing medicine-carrying nanofibers of core-shell structure by virtue of Pickering emulsion electrospinning

A technology of electrospinning and drug-loaded nanometers, which can be used in fiber processing, pharmaceutical formulations, rayon manufacturing, etc., and can solve problems such as limiting nanofiber materials

Inactive Publication Date: 2015-09-30
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional emulsions usually need to add small molecule surfactants, such as Span 80, etc., to maintain stability, and these surfactants are often

Method used

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  • Method for preparing medicine-carrying nanofibers of core-shell structure by virtue of Pickering emulsion electrospinning
  • Method for preparing medicine-carrying nanofibers of core-shell structure by virtue of Pickering emulsion electrospinning
  • Method for preparing medicine-carrying nanofibers of core-shell structure by virtue of Pickering emulsion electrospinning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Preparation of amphiphilic modified iron ferric oxide nanoparticle emulsifier: disperse 100mg ferric iron tetroxide ultrasonically for 30min into deionized water to obtain a dispersion with a mass fraction of 10%. Inject 5ml of oleic acid at a speed of 5ml / h to obtain an amphiphilic oleic acid-modified nanoparticle emulsifier;

[0024] (2) Preparation of Pickering emulsion: Firstly, the amphiphilic modified iron ferric oxide nanoparticles prepared in step (1) were dispersed into 1 g N,N-dimethylformamide and 9 g chloroform by ultrasonication for 30 min as an emulsifier Then add 1.0g polylactic acid to the mixed organic solvent of 1g N,N-dimethylformamide and 9g chloroform, fully dissolve under magnetic stirring conditions, and then use this solution as an oil phase at room temperature at high speed Add it under the condition of stirring in the above-mentioned modified iron ferric oxide nanoparticle dispersion with amphiphilicity, and finally add 1.5ml of an aqueous ...

Embodiment 2

[0029] (1) Preparation of amphiphilic modified nano-silica particle emulsifier: 150 mg of nano-silica particle was dispersed in deionized water by ultrasonic 60 min to obtain a dispersion with a mass fraction of 15%. Inject 10ml of oleic acid at a speed of 10ml / h to prepare an amphiphilic oleic acid-modified nano-silica particle emulsifier;

[0030] (2) Preparation of Pickering emulsion: first, the amphiphilic modified nano-silica particles prepared in step (1) were dispersed into a mixed solvent of 10 g tetrahydrofuran and 10 g chloroform as an emulsifier ultrasonically for 60 min, and then 1.5 g Add polyε-caprolactone into the mixed organic solvent of 10g tetrahydrofuran and 10g chloroform and fully dissolve under the condition of magnetic stirring, and then add this solution as an oil phase to the above-mentioned amphiphilic modification under the condition of high-speed stirring at room temperature. In the nano-silica particle dispersion, finally add 2.0ml of an aqueous so...

Embodiment 3

[0035] (1) Preparation of amphiphilic modified iron ferric oxide nanoparticle emulsifier: 200 mg nano iron ferric oxide ultrasonic 60min is dispersed in deionized water to obtain a dispersion with a mass fraction of 20%. Under stirring conditions, Inject 15ml oleic acid at a speed of 15ml / h to prepare oleic acid modified nanoparticle emulsifier;

[0036] (2) Preparation of Pickering emulsion: firstly, the amphiphilic modified iron ferric oxide nanoparticles prepared in step (1) were dispersed into 18 g of N,N-dimethylformamide and 2 g of acetone by ultrasonication for 60 min as an emulsifier Then add 2.0g polylactic acid to the mixed organic solvent of 18g N,N-dimethylformamide and 2g acetone, fully dissolve under the condition of magnetic stirring, then use this solution as oil phase at room temperature Add it into the above-mentioned amphiphilic modified iron ferric oxide nanoparticle dispersion under stirring conditions, and finally add 2.5ml of an aqueous solution containi...

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Abstract

The invention relates to a method for preparing medicine-carrying nanofibers of a core-shell structure by virtue of Pickering emulsion electrospinning. The method comprises the following steps: 1) the preparation of a Pickering emulsion; 2) the electrospinning of the Pickering emulsion, namely sucking the Pickering emulsion obtained in the step 1) into a 10ml injector, connecting an injection pump with a receiving device, and preparing the nanofibers of the Pickering emulsion by virtue of electrospinning under the conditions of a DC voltage within the range of 15-25kV, an injection rate within the range of 0.1ml/h to 1.0ml/h and an interval between the receiving plate and the needle head of the injector within the range of 15cm to 20cm. Compared with the prior art, the method has the advantages that no any small molecular surfactant having biotoxicity needs to be added to the prepared Pickering emulsion as an emulsifier and the specific functions of nanoparticles are introduced to the Pickering emulsion, and therefore, the Pickering emulsion has specific advantages in application in the fields such as medicine release and tissue engineering.

Description

technical field [0001] The invention relates to a method for preparing drug-loaded nanofibers with a core-shell structure, in particular to a method for preparing drug-loaded nanofibers with a core-shell structure by electrostatic spinning of Pickering emulsion. Background technique [0002] The polymer nanofiber prepared by electrospinning is a good drug-loading material. On the one hand, according to the consensus of the pathology community, the larger the specific surface area of ​​the drug and drug carrier, the faster the decomposition rate of the drug particles. The diameter of nanofibers is at the nanometer level, which makes nanofibers have a huge surface area. Using them as drug-loading materials can slowly decompose and release some drugs that were originally difficult to be absorbed by the human body, and have a therapeutic effect. On the other hand, using a degradable or absorbable polymer material as a drug-loading matrix, the drug can be implanted into a specif...

Claims

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Application Information

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IPC IPC(8): D01F6/92D01F1/10D01D5/00A61K47/34A61K47/04A61K47/02A61K9/51A61L27/18A61L27/02A61L27/04A61L27/06A61L27/08A61L27/54A61L27/50
Inventor 喻发全蔡宁代琴侯大军罗晓刚薛亚楠
Owner WUHAN INSTITUTE OF TECHNOLOGY
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