A novel synthetic method of pyrrole derivatives
A synthetic method, pyrrole technology, applied in the direction of organic chemistry, etc.
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Embodiment 1
[0035]
[0036] At room temperature, add 100mmol of the above formula (I) compound, 100mmol of the above formula (II) compound, 100mmol of the above formula (III) compound, 4mmol of the catalyst Pd(MeCN) in the appropriate amount of organic solvent acetonitrile in the reactor 2 Cl 2 , 200mmol base N-(4-pyridylmethyl)ethylamine and 10mmol accelerator (a mixture of 2.5mmol copper trifluoromethanesulfonate and 7.5mmol yttrium nitrate), then warming up to 60°C, and stirring the reaction at this temperature 8 hours;
[0037]After the reaction, the reaction mixture was poured into deionized water, fully shaken, then extracted 2-3 times with ethyl acetate, the organic phases were combined, and the organic phases were washed with saturated brine and deionized water, and then washed with anhydrous Magnesium sulfate was dried, concentrated under reduced pressure, and the residue was separated by 200-300 mesh silica gel column chromatography, and the mixed solution of acetone and pet...
Embodiment 2
[0041]
[0042] At room temperature, add 100mmol of the above formula (I) compound, 120mmol of the above formula (II) compound, 110mmol of the above formula (III) compound, 6mmol of the catalyst Pd(MeCN) in the appropriate amount of organic solvent acetonitrile in the reactor 2 Cl 2 , 250mmol base N-(4-pyridylmethyl)ethylamine and 15mmol accelerator (a mixture of 3mmol copper trifluoromethanesulfonate and 12mmol yttrium nitrate), then warming up to 70°C, and stirring the reaction at this temperature for 6 hours ;
[0043] After the reaction, the reaction mixture was poured into deionized water, fully shaken, then extracted 2-3 times with ethyl acetate, the organic phases were combined, and the organic phases were washed with saturated brine and deionized water, and then washed with anhydrous Magnesium sulfate was dried, concentrated under reduced pressure, and the residue was separated by 200-300 mesh silica gel column chromatography, and the mixed solution of acetone and ...
Embodiment 3
[0047]
[0048] At room temperature, in the appropriate amount of organic solvent acetonitrile in the reactor, add 100mmol of the above formula (I) compound, 150mmol of the above formula (II) compound, 120mmol of the above formula (III) compound, 8mmol of the catalyst Pd (MeCN) 2 Cl 2 , 300mmol base N-(4-pyridylmethyl)ethylamine and 20mmol accelerator (a mixture of 4.5mmol copper trifluoromethanesulfonate and 15.5mmol yttrium nitrate), then warming up to 90°C, and stirring the reaction at this temperature 4 hours;
[0049] After the reaction, the reaction mixture was poured into deionized water, fully shaken, then extracted 2-3 times with ethyl acetate, the organic phases were combined, and the organic phases were washed with saturated brine and deionized water, and then washed with anhydrous Magnesium sulfate was dried, concentrated under reduced pressure, and the residue was separated by 200-300 mesh silica gel column chromatography, and the mixed solution of acetone and...
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