Continuous High Pressure Comprehensive Extraction Method of Licorice Components
A comprehensive extraction and high-pressure technology, applied in the field of extraction and separation of licorice components, can solve the problems of limiting the feasibility of ultra-high pressure technology application, the inconsistency of the primary extraction process, and the inability to large-scale production.
Active Publication Date: 2020-03-31
NINGBO ZHONGHUI TIANYI BIOTECH CO LTD
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Problems solved by technology
[0007] Through the research of the searched literature and papers, it is found that they have a common deficiency, that is, they cannot be mass-produced by ultra-high pressure methods. The main reasons are: a. The amount of each experiment is very small (10g~ 100g); b. Use organic solvents (such as ethanol) as extraction solvents; c. Intermittent operation, no continuity in the primary extraction process; d. All separation and removal of impurities are performed in organic solvents
These deficiencies strictly limit the feasibility of the application of ultra-high pressure technology in industrial scale production
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[0017] Please also see figure 1 and figure 2 A method for continuous high-pressure comprehensive extraction of licorice components, comprising the following steps:
[0018] Continuous high-pressure leaching: After the licorice is crushed, a predetermined amount of water is used to adjust the crushed licorice into a slurry, and the slurry is pushed into the high-pressure extraction container by a high-pressure pump at room temperature. The material is continuously fed in and out to achieve fluid state leaching, and then obtain slurry-like high-pressure leaching material. Among them, the licorice is crushed to 60-80 meshes, the mass of the licorice powder is 0.25 times that of water, the pressure in the high-pressure extraction vessel is 120-150 MPa, and the predetermined pressure time is 3-8 minutes.
[0019] Two-stage flocculation and impurity removal: Dilute the pulpy high-pressure leaching material with water and then filter to obtain the filtrate, use the first combinati...
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The invention provides a method for continuously and comprehensively extracting the liquorice ingredient with high pressure. The method comprises the steps that high-pressure digestion is continuously carried out, wherein water is utilized for mixing smashed liquorice into pulp, a high-pressure pump is utilized for pushing the pulp into a high-pressure digestion container, and the pulp is continuously fed and discharged within the pressure bearing time to achieve liquid state digestion; two-stage flocculation and purification are carried out, wherein water is used for diluting the pulp high-pressure digested materials, then filtering is carried out to obtain filtered clear liquid, and tannin, heavy metal and protein in the filtered clear liquid are removed; complexing separation is carried out, wherein a complexing agent is utilized for dividing deeply-purified liquid into solid and liquid phases; follow-up purification is carried out, wherein the PH value of the liquid phase is adjusted by dilute acid for precipitation, ethyl alcohol for precipitation is used for reflux extraction and filtering to obtain a filter cake with glycyrrhiza polysaccharide and an ethanol extract with glycyrrhizic acid, and mono-ammonium glycyrrhizinate is obtained from the extracted solution; reflux extraction and filtering are carried out on the solid phase obtained through complexing separation at preset temperature by means of acid alcohol, vacuum concentration is carried out on filtered clear liquid, and glycyrrhiza uralensis is obtained.
Description
technical field [0001] The invention relates to the technical field of separation and extraction of licorice components, in particular to a method for continuous high-pressure comprehensive extraction of licorice components. Background technique [0002] Licorice ranks first in the field of traditional Chinese medicine, and is one of the most widely used varieties of natural medicinal materials. my country is a major producer of licorice and a major exporter of licorice. Domestic pharmaceutical companies mostly use licorice slices and extracts. In international trade, primary products such as decoction pieces, extracts, and crude glycyrrhizic acid are exported, and products with high technical content are about 75% (HPLC method) monoammonium glycyrrhizinate, but the added value of these products is not high. Therefore, it is a very urgent task to speed up the improvement of high value-added deep processing technology of my country's licorice industry and change the structure ...
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IPC IPC(8): A61K36/484B01D11/02
Inventor 伍昌华杨玉梅
Owner NINGBO ZHONGHUI TIANYI BIOTECH CO LTD