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A kind of coffee acid tablet and preparation method thereof

A technology of caffeic acid and alcohol anhydride monostearate, which is applied in the direction of pharmaceutical formulations, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., to achieve good stability, high dissolution rate, and easy absorption Effect

Active Publication Date: 2018-03-06
DEZHOU DEYAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there is still room for improvement in this caffeic acid tablet, for example, dissolution rate, stability, etc., there is still a lot of room for improvement

Method used

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  • A kind of coffee acid tablet and preparation method thereof
  • A kind of coffee acid tablet and preparation method thereof
  • A kind of coffee acid tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0025] Preparation Example 1: Preparation of Composition A

[0026] Weigh each component in composition A according to the amount in Table 1: caffeic acid, PEG6000, hypromellose, hypromellose, xylitol anhydride monostearate, hydroxyl compound, 55% ethanol;

[0027] Then melt the above-mentioned amount of caffeic acid and PEG6000 at about 135°C, fully mix with the above-mentioned amount of hypromellose and hypromellose, and then add polyol, xylitol anhydride monostearate mixed with 55% ethanol solution, granulated and dried to prepare compositions A1-6 respectively.

[0028] Table 1: A composition

[0029]

[0030] Wherein, the unit of all numerical values ​​is g.

preparation example 2

[0031] Preparation Example 2: Preparation of Composition B

[0032] Weigh each component in composition B according to the following amounts:

[0033] Composition B: 100g sodium carboxymethyl starch, appropriate amount of starch, 6g xylitol anhydride monostearate, appropriate amount of 55% ethanol;

[0034] Fully mix the above-mentioned sodium carboxymethyl starch and starch, add xylitol anhydride monostearate and 55% ethanol solution, mix, granulate and dry to obtain composition B.

preparation example 3

[0035] Preparation Example 3: Preparation of Disintegrant

[0036] Weigh each component of the disintegrant according to the amount in Table 2, and record them as disintegrants C1-C4.

[0037] Table 2: Disintegrants

[0038]

[0039] Wherein, the unit of all numerical values ​​is g.

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PUM

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Abstract

The present invention relates to a kind of caffeic acid tablet, and its production raw material comprises composition A, composition B and quick-acting disintegrating agent and lubricant; wherein A composition contains caffeic acid, PEG6000, hypromellose, hypromellose , xylitol monostearate, containing hydroxyl compound and 55% ethanol; B composition is sodium carboxymethyl starch, starch, xylitol monostearate and an appropriate amount of 55% ethanol; the disintegrant is Acrylic resin, croscarmellose sodium; lubricant is magnesium stearate. The caffeic acid tablet of the present invention is not only equivalent to or surpasses the coffee tablet of the prior art in terms of dissolution rate and bioavailability, and is easy to be absorbed by the human body, but also has very good stability.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a caffeic acid tablet and a preparation method thereof. Background technique [0002] Bleeding disorder is a disease that threatens the patient's life. At present, commonly used hemostatic drugs in clinical practice, such as vitamin K and 6-aminocaproic acid, have slow hemostatic effects and have adverse reactions in varying degrees. Therefore, there is an urgent need to develop new hemostatic drugs with higher curative effect, faster action and lower side effects. [0003] Caffeic acid is a component of chlorogenic acid contained in various Chinese herbal medicines such as ramie, capillary, artichoke, etc., English name: Caffeic acid, chemical name: 3-(3,4-dihydroxyphenyl)-acrylic acid, molecular formula: C9H8O4, molecular weight: 180.16, the chemical structure is as follows: [0004] [0005] Due to the low extraction yield from plants, Nanjing Institute of Pharmaceutical S...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/192A61K47/38A61K47/36A61K47/34A61K47/26A61K47/14A61K47/10A61P7/04A61K47/32
Inventor 卞建钢潘秀芝牟金香肖梅花张庆霞宋桓王建华
Owner DEZHOU DEYAO PHARMA