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A method for in-situ synthesis of gold nanorods/graphene oxide composites

A gold nanorod, in-situ synthesis technology, applied in the nano field, can solve problems such as complex preparation process, achieve the effects of simple operation, green and mild reaction conditions, and high loading capacity

Active Publication Date: 2017-05-03
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the preparation of nanoparticle / graphene composites usually uses higher than normal temperature or the use of lasers to load nanoparticles on graphene, and the preparation process is complicated. Uniformly distributed nanoparticles / graphene composites are of great significance, and the preparation of gold nanorods / graphene oxide composites by in situ synthesis is of great significance for material preparation and subsequent biomedical applications

Method used

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  • A method for in-situ synthesis of gold nanorods/graphene oxide composites
  • A method for in-situ synthesis of gold nanorods/graphene oxide composites
  • A method for in-situ synthesis of gold nanorods/graphene oxide composites

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Take 5ml of cetyltrimethylammonium bromide solution (0.2M), 250μl of chloroauric acid solution (0.01M), 4.75ml of deionized water, 0.6ml of sodium borohydride solution (0.02M) and mix them After shaking vigorously for 30 seconds, it was left to stand at 30° C. for 7 hours.

[0023] (2) Mix 20 mg of ground graphene oxide with 60 ml of sodium polystyrene sulfonate solution dissolved in 0.5 g and sonicate (800 W, 20 minutes), and centrifuge at high speed for 3 times (11000 rpm, 15 minutes) after sonication, and finally the supernatant solution was redispersed in 50ml of water.

[0024] (3) Mix 50ml CTAB (0.1M) with the product obtained in step (2), and add 5ml chloroauric acid (0.01M), 0.8ml silver nitrate (0.01M), 550ul ascorbic acid (0.1M), and finally add 125ul step (1) The obtained product was added quickly and shaken for 30 seconds, and kept at a constant temperature of 27°C for 42 hours.

[0025] (4) The product obtained in step (3) was centrifuged at high spee...

Embodiment 2

[0028] (1) Take 5ml of cetyltrimethylammonium bromide solution (0.2M), 250μl of chloroauric acid solution (0.01M), 4.75ml of deionized water, 0.6ml of sodium borohydride solution (0.02M) and mix them After shaking vigorously for 30 seconds, it was left to stand at 30° C. for 7 hours.

[0029] (2) Mix 5mg of ground graphene oxide with 40ml of sodium polystyrene sulfonate solution dissolved in 1.2g and sonicate (500W, 20 minutes). solution was redispersed in 50ml of water.

[0030] (3) Mix 50ml CTAB (0.1M) with the product obtained in step (2), and add 5ml chloroauric acid (0.01M), 0.8ml silver nitrate (0.01M), 550μl ascorbic acid (0.1M), and finally add 125μl step (1) The obtained product was added quickly and shaken for 30 seconds, and kept at a constant temperature of 27°C for 40 hours.

[0031] (4) The product obtained in step (3) was centrifuged at high speed for 3 times (14000rpm, 20 minutes), and the centrifuged substrate was redispersed in water to obtain the final pro...

Embodiment 3

[0032] (1) Take 5ml of cetyltrimethylammonium bromide solution (0.2M), 250μl of chloroauric acid solution (0.01M), 4.75ml of deionized water, 0.6ml of sodium borohydride solution (0.02M) and mix them After shaking vigorously for 30 seconds, it was left to stand at 30° C. for 9 hours.

[0033] (2) Mix 15 mg of ground graphene oxide with 60 ml of sodium polystyrene sulfonate solution dissolved in 0.6 g and sonicate (700 W, 20 minutes), and centrifuge at high speed for 3 times after sonication (10,000 rpm, 15 minutes), and finally the supernatant solution was redispersed in 50ml of water.

[0034] (3) Mix 50ml CTAB (0.1M) with the product obtained in step (2), and add 5ml chloroauric acid (0.01M), 0.8ml silver nitrate (0.01M), 550μl ascorbic acid (0.1M), and finally add 125μl step (1) The obtained product was quickly added and shaken for 30 seconds, and kept at a constant temperature of 25°C for 48 hours.

[0035] (4) The product obtained in step (3) was centrifuged at high spe...

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Abstract

The invention relates to a method for in situ synthesis of gold nanorods / graphene oxide composite material.The method comprises concrete steps: mixing graphene oxide modified by sodium polystyrenesulfonate, a secondary growth solution of growth gold nanorods and gold seeds; and standing the mixture at constant temperature for a period of time. The method for in situ synthesis of gold nanorods / graphene oxide composite material has following beneficial effects: the method has a green and moderate reaction condition and high repeatability and is easily applied; gold nanorods / graphene oxide composite material prepared by the method has high loading capability; gold nanorods are distributed uniformly; and the method has a broad prospect for integration of diagnosis and treatment by means of increase in efficiency of photothermal therapy and subsequent moderation of antibodies and drug loads.

Description

technical field [0001] The invention relates to a method for in-situ synthesis of a gold nanorod / graphene oxide composite material, which belongs to the field of nanotechnology. Background technique [0002] In order to further improve the efficiency of photothermal therapy, modify antibodies, load drugs, and design an integrated system for diagnosis and treatment, more and more researchers attach nanoparticles to graphene and its derivatives, such as gold nanorods, silver, oxynitride, etc. copper and copper sulfide etc. However, when nanoparticle / graphene composites are prepared using a method higher than normal temperature or laser irradiation, the loading of nanoparticles is low, and the distribution of nanoparticles attached to graphene is not uniform. On the one hand: increasing the loading of nanoparticles is beneficial to improve the efficiency of photothermal therapy. On the other hand, the uniform distribution of nanoparticles loaded on graphene can increase the s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24
Inventor 陈炳地孙兵妹乐文俊姚爱华
Owner TONGJI UNIV
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