41results about How to "Green and mild reaction conditions" patented technology

The invention relates to a method for in situ synthesis of gold nanorods/graphene oxide composite material.The method comprises concrete steps: mixing graphene oxide modified by sodium polystyrenesulfonate, a secondary growth solution of growth gold nanorods and gold seeds; and standing the mixture at constant temperature for a period of time. The method for in situ synthesis of gold nanorods/graphene oxide composite material has following beneficial effects: the method has a green and moderate reaction condition and high repeatability and is easily applied; gold nanorods/graphene oxide composite material prepared by the method has high loading capability; gold nanorods are distributed uniformly; and the method has a broad prospect for integration of diagnosis and treatment by means of increase in efficiency of photothermal therapy and subsequent moderation of antibodies and drug loads.

The invention belongs to the field of inorganic nanometer materials and relates to a preparation method of a ZnO-loaded CdIn2S4 nano-cube composite catalyst and the application of the catalyst to the field of environmental governance. CdIn2S4 nano-cubes are synthesized by using cadmium nitrate tetrahydrate, indium nitrate monohydrate and thioacetamide as raw materials, and a ZnO-loaded CdIn2S4 nano-cube compound is synthesized through deposition and a hydrothermal method. The composite material has the advantages of large specific surface area, wide spectral response range, strong light-harvesting ability, convenience in separation of photon-generated carriers and the like and has very excellent solar photocatalytic degradation ability. A synergistic effect can be used in the ZnO-loaded CdIn2S4 nano-cube composite material, effective transfer and separation of the photon-generated carrier are realized, the light absorption range of the compound is widened, and effective degradation of tetracycline hydrochloride and ofloxacin by the compound under solar light is realized.

The invention relates to a copper nanosheet and a preparation method and application of the copper nanosheet. The preparation method comprises the following steps that 1, a protective agent, a reducing agent, a copper precursor and an alcohol solution or an alcohol aqueous solution are stirred to be uniform; 2, reduction reaction is carried out in the solution obtained in the step 1 in a heating manner till the reaction is thorough; and 3, washing is carried out after the reaction is finished, precipitate is obtained and dried, and the copper nanosheet is obtained, wherein the reducing agent is selected from ascorbic acid, and the protective agent is a high molecular surfactant. A complex chelating agent does not need to be added in the preparation process, intermediate processes such as separation purification, activation sensitization and the like are not needed, and the reaction condition is mild.

The invention discloses a polycarbazole-loaded nano-palladium material as well as a preparation method and application thereof. Specifically, the average grain diameter distribution of palladium nanoparticles prepared by the invention is about 4.2 nm and the palladium nanoparticles are uniformly dispersed on a substrate polycarbazole material. The material can be used for catalyzing Suzuki reaction of aryl bromide and aryl chloride under light illumination and water phase conditions, and has the characteristics of high conversion efficiency, wide applicable range, green and moderate reaction conditions and the like. After conversion reaction is finished, a substrate is separated from a reaction system and a catalysis system can be used for carrying out the next round of reaction; after thecatalysis system is circulated for 3 times, the catalysis system can still keep stable and the catalytic activity is not obviously reduced.

The invention relates to a preparation method of nano copper particles. The preparation method comprises the following steps that (1) a protective agent is evenly dispersed into an alcoholic solutionor an aqueous solution of alcohol, then a reducing agent is added, and the solution is stirred evenly; (2) copper precursor is added into the solution obtained in the step (1), the solution is stirredevenly and heated to 70 DEG C, and then the solution is heated for one hour or longer when the color of the solution starts to change; and (3) washing is conducted after the reaction is finished, drying is conducted after sediment is taken out, and the nano copper particles are obtained. In the preparation process, composite chelating agents do not need to be added, middle processes including separation and purification, or activation and sensitization are not needed, and reaction conditions are mild. In addition, the nano copper particles generated through the preparation method are small inparticle size, good in dispersity, high in monodispersity, and great in oxidization resistance, and can be put into mass production and applied to the field of conductive printing ink.

The invention relates to a synthesis method for a polybrominated benzene [1.3] oxazine derivative, comprising the following steps of: carrying out reaction of compounds shown in formula (I) and N-bromo-succinimide (NBS) in a solvent at 25-100 DEG C to obtain the polybrominated benzene [1.3] oxazine derivative shown in formula (II) after the reaction is completed. The compounds shown in the formula(I) and the formula (II) are as shown in the description, wherein R is chosen from phenyl, substituted phenyl, C1-C5 alkyl (preferably isopropyl) or thiophene. The synthesis method has the advantagesof being mild in reaction conditions, environment-friendly, simple in operation and capable to obtain polybrominated benzene oxazine compounds which cannot be obtained by conventional methods throughone pot multi-step reaction.

The invention relates to a method for preparing an aromatic alpha-diketone compound through electrochemical oxidation, and belongs to the technical field of carbonyl compound preparation. The invention discloses a method for preparing an aromatic alpha-diketone compound through electrochemical oxidation. The method uses an electrochemical oxidation means, provides reaction power through a new benzyl position C-H bond carbonylation method, uses current to provide reaction power, uses gain and loss of electrons on an electrode as a redox agent, avoids the use of an additional stoichiometric redox agent, and has green and mild reaction conditions. In addition, in order to avoid the situation that free radical intermediates generated in the reaction process are polymerized on the surfaces of the electrodes, so that the electrodes are passivated, and the electrolysis efficiency is reduced, corresponding electrolyte is selected, the solvent conductivity is improved, meanwhile, the electrolyte can serve as a reaction medium additionally, excessive oxidation of a substrate is avoided, and the passivation phenomenon of the electrodes is avoided; and more importantly, free radicals generated by oxidation can be used as a hydrogen atom transfer reagent in the reaction process, so that one substance has multiple purposes, and the atom economy is relatively high.

The invention discloses a synthesis method of trans-alpha-benzoinoxime and belongs to the field of the organic chemical synthesis technology. The trans-alpha-benzoinoxime is represented by a structural formula (I). The synthesis method comprises catalyzing benzaldehyde through imidazole salt ion liquid, enabling the catalyzed benzaldehyde and benzoin to perform condensation reaction under the alkaline condition to generate alpha-benzoin, enabling alpha-benzoin crude products to be crystallized again, enabling the crystallized alpha-benzoin crude products to react with hydroxylamine hydrochloride or hydroxylamine sulphate to generate the trans-alpha-benzoinoxime, and separating the trans-alpha-benzoinoxime through column chromatography to obtain purified products. The synthesis method of the trans-alpha-benzoinoxime is simple, convenient, mild and environment-friendly in reaction condition, easy to implement, good in yield, low in cost, simple in product purification and capable of obtaining high-purity trans-alpha-benzoinoxime.

The invention relates to chemical synthesis methods and aims to provide a method for synthesizing N-substituted carbazole. The method comprises the following steps: adding halogenated N-substituted diphenylamine and a ligand into the same solvent for dissolving, dripping the obtained solution into potassium tert-butoxide, and stirring and reacting at the temperature of 30-160 DEG C for 6-12 hours; adding saturated sodium chloride to carry out a quenched reaction, extracting for three times by using ethyl acetate, and merging the organic phase; drying anhydrous sodium sulfate, filtering, performing reduced pressure distillation, removing the ethyl acetate, and performing thin-layer chromatography separation, thereby obtaining the N-substituted carbazole. According to the method disclosed by the invention, the defect in the prior art that transition metals are used is overcome, the reaction conditions are green and mild, and the method is suitable for industrial production.

The invention discloses a green preparation method of an aryl [alpha]-keto ester compound. The method comprises the specific steps that an [alpha]-diazo compound serves as a reaction raw material, copper sulfate serves as a catalyst, water serves as a solvent, a target product aryl [alpha]-keto ester compound is prepared through a reaction at the temperature of 60 DEG C, the structural general formula of the [alpha]-diazo compound is shown in the specification, and the structural general formula of the correspondingly prepared target product aryl [alpha]-keto ester compound is shown in the specification. The method for synthesizing the target product aryl [alpha]-keto ester compound by catalyzing the [alpha]-diazo compound derivative with copper sulfate has the advantages that the reactioncondition is green and mild, the catalyst is cheap and easy to obtain, the operation is simple and convenient, the yield is relatively high, the universality of a reaction substrate is wide, and thelike.

The invention provides applications of a chiral organic alkali in preparation of a chiral sulfur-containing indole compound in a water-oil two-phase system, particularly a method for asymmetrically vulcanizing indole by catalyzing mercaptan in a water-oil two-phase system through chiral organic alkali small molecule, wherein the used catalyst is a small molecule chiral organic alkali, the vinylogous imine intermediate generated from racemic p-toluenesulfonyl indole under an alkali condition is vulcanized so as to obtain the corresponding chiral indole sulfide, the yield can achieve 99%, and the enantiomer excess can achieve 98%. According to the present invention, the operation is simple and practical, and is easy to operate, the catalyst is commercially available, the water is used as the solvent, the reaction conditions are mild and green, the yield is high, the enantioselectivity is good, and the reaction is performed in the water phase so as to provide the advantage of environmental protection; and the chiral indole sulfide synthesized through the asymmetric vulcanizing and the indoline sulfide obtained through the derivatization have potential medical values.

The invention discloses a green synthesis method of imidazoline under visible light catalysis, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: 1) adding N-phenylglycine, a photocatalyst, an oxidant, a solvent, an arylamine compound, an aldehyde compound or an imine compound into a dry Schlenk tube; 2) carrying out air suction and exchange operations on the reaction bottle filled with the material for three times so as to ensure that no water or oxygen exists in the reaction tube and then sealing the reaction tube; 3) placing the reaction bottle under the irradiation of a Blue LED, carrying out a stirring reaction, and ending the reaction when TLC detects that the aldehyde compound disappears; and 4) transferring the reaction solution in the Schlenk tube into an eggplant-shaped bottle, adding a proper amount of silica gel, concentrating under reduced pressure, and purifying the obtained residue by column chromatography to obtain the product imidazoline. Compared with the prior art, the method has the characteristics of simple synthetic route, cheap and easily available raw materials without synthesis, simplicity and convenience in operation, environmental friendliness, mild reaction conditions, wide substrate application range and the like.

The invention discloses gadolinium-doped gold nanoparticles, a biomimetic synthesis method and application of the gadolinium-doped gold nanoparticles in stem cells, the method adopts silk fibroin as a reducing agent and a stabilizing agent, Au < 3 + > is fixed on the silk fibroin by utilizing rich amino acid residues of the silk fibroin, the Au < 3 + > is reduced into Au < + >, then the pH value is adjusted to 9-10, and the Au < + > is further reduced into Au. And adding a gadolinium chloride solution to prepare the gadolinium-doped gold nanoparticles. The method has the following advantages: (1) the reaction conditions of the method are green and mild, the operation is simple, the consumed time is short, and the repeatability is strong; (2) according to the method, silk fibroin is used as a reducing agent and a stabilizing agent for the first time, and chloroauric acid reduction, stabilization and gadolinium ion doping are completed in a reaction system; and (3) the gold nanoparticles prepared by the method and the stem cells marked by the gold nanoparticles have good photothermal effect, biocompatibility and MR/CT dual-mode imaging capability, so that the gold nanoparticles and the stem cells marked by the gold nanoparticles have wide prospects in the aspects of stem cell imaging tracing and treatment.

The invention discloses a polycarbazole loaded cobalt hybrid material and a preparation method and application thereof. Specifically, the polycarbazole loaded cobalt oxime hybrid material is preparedby a post-modification coordination method, and cobalt is uniformly dispersed on a substrate polycarbazole material. The material can catalyze a hydrogen evolution reaction under an illumination condition, and has the characteristics of high efficiency, green and mild reaction conditions and the like. After the conversion reaction is finished, the catalyst is separated from the system and put intothe next round of reaction, the catalyst can still keep stable after being circulated for three times, and the catalytic activity of the catalyst is not obviously reduced.

The invention provides a method for in-situ synthesis of montmorillonite/gold nanorod composite materials, and belongs to the field of metal powder processing. The method for in-situ synthesis of themontmorillonite/gold nanorod composite materials comprises the following steps: montmorillonite water solution is fed in hexadecyl trimethyl ammonium bromide water solution for uniform mixing; chloroauric acid water solution and silver nitrate water solution are fed to obtain mixed liquid A; ascorbic acid water solution is fed in the mixed liquid A; after the solution becomes colorless and transparent, gold seed liquid is fed for constant-temperature standing by 6-12 hours to obtain mixed liquid B; the mixed liquid B is centrifuged; and precipitates are taken and suspended in water to obtain finished products. The method is green and mild in reaction condition, simple in operation, short in consumed time, high in repeatability, high in material load and uniform in distribution of gold nanorods, and achieves broad prospect on the aspect of realizing integration of diagnosis and treatment through improvement of photothermal treatment and subsequent antibody modification and medicine carrying.