Green preparation method of aryl [alpha]-keto ester compound
A technology of compounds and ketoesters, which is applied in the field of green preparation of aryl α-ketoesters, can solve the problems of cumbersome steps, increased reaction costs, complex reaction conditions, etc., and achieve green and mild reaction conditions and easy operation Effect
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[0015] Preparation of Compound 1:
[0016]
Embodiment 1
[0034] Disperse ethyl 2-diazo-2-phenylacetate (0.1mmol) and copper sulfate (0.02mmol) in 1mL water, react at 60°C for 2h, extract with 25mL×5 dichloromethane, collect the organic phase, anhydrous sulfuric acid Dry over sodium, remove the solvent by rotary evaporation under reduced pressure, and separate by silica gel column chromatography to obtain a yellow oily compound with a yield of 94%. 1 H NMR (400MHz, CDCl 3 )δ8.01(d, J=7.2Hz, 2H), 7.65(t, J=7.2Hz, 1H), 7.51(t, J=8.0Hz, 2H), 4.45(q, J=7.2Hz, 2H) ,1.43(t,J=7.2Hz,3H), 13 C NMR (100MHz, CDCl 3 ) δ 186.6, 164.0, 135.0, 132.6, 130.1, 129.0, 62.5, 14.2.
Embodiment 2
[0038] Preparation of compound 2:
[0039]
[0040] Disperse methyl 2-diazo-2-phenylacetate (0.1mmol) and copper sulfate (0.02mmol) in 1mL water, react at 60°C for 1h, extract with 25mL×5 dichloromethane, collect the organic phase, and anhydrous sulfuric acid Dry over sodium, remove the solvent by rotary evaporation under reduced pressure, and separate by silica gel column chromatography to obtain a white solid compound with a yield of 87%. 1 H NMR (600MHz, CDCl 3 )δ8.01(d, J=7.2Hz, 2H), 7.65(t, J=7.2Hz, 1H), 7.50(t, J=7.2Hz, 2H), 3.97(s, 3H). 13 C NMR (150MHz, CDCl 3 ) δ 186.2, 164.2, 135.1, 132.5, 130.2, 129.0, 52.9.
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