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A biomimetic polymer and method and application for making durable dual biomimetic polymer coatings

A polymer coating and polymer technology, which is applied in coatings, biocide-containing paints, antifouling/underwater coatings, etc., can solve the problems of large polydopamine aggregate size, heavy coating color, and poor durability , to achieve the effects of good anti-biological pollution performance and bactericidal performance, improved coating stability, and simple and easy preparation method

Active Publication Date: 2020-04-10
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned coating preparation method is relatively cumbersome, and due to the relatively large size of polydopamine aggregates, the coating color is heavy, and the durability is relatively poor, which greatly limits its application in contact lenses and corneas with high transparency requirements. Applications in plastic mirrors and goggles

Method used

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  • A biomimetic polymer and method and application for making durable dual biomimetic polymer coatings
  • A biomimetic polymer and method and application for making durable dual biomimetic polymer coatings
  • A biomimetic polymer and method and application for making durable dual biomimetic polymer coatings

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preparation example Construction

[0046] The preparation method of durable double biomimetic polymer coating of the present invention comprises the following steps:

[0047] Step 1, preparation of biomimetic polymers:

[0048] A1: According to the mole percentage, (1~90): (9~60): (1~70) will respectively contain the (meth)acrylic acid of zwitterionic group W, amino hydrochloride S and quaternary ammonium cationic group T The ester monomer is dissolved in the solvent, the mass percentage of the (meth)acrylate monomer and the solvent is (4-20): (80-96), and the monomer mixture is obtained;

[0049] B1: According to the mass percentage of initiator and (meth)acrylate monomer (0.1-5.0): (95.0-99.9), the initiator is dissolved in the solvent to obtain an initiator solution;

[0050] C1: Mix the monomer mixed solution and the initiator solution according to the mass percentage of (70-95): (5-30), mix them evenly, transfer them to the constant pressure dropping funnel, and use 20%-50% / The feed rate of 1 hour is ad...

Embodiment 1

[0063] (Meth)acrylic acid ester copolymer (1 ) preparation:

[0064] With 2-methacryloyloxyethylphosphorylcholine (MPC), 2-aminoethylmethacrylate hydrochloride (AEMA) and methacryloyloxyethyltrimethylammonium chloride (TMA) as monomer, potassium persulfate (K 2 S 2 o 8 ) is a free radical initiator; take by weighing 5.31g (18mmol) MPC, 1.85g (11mmol) AEMA and 1.48g (7mmol) TMA respectively according to MPC, AEMA and TMA mole percentage feed ratio 50:30:20, then according to mass percentage Dissolve three kinds of (meth)acrylate monomers in deionized water at a ratio of 4:96 to obtain a monomer mixture; weigh 0.08541 g of Potassium sulfate is dissolved in deionized water to obtain an initiator solution; the monomer mixed solution and the initiator solution are mixed uniformly according to the mass percentage of 80:20, and transferred to a constant pressure dropping funnel. In a three-necked bottle equipped with a thermometer and a constant pressure dropping funnel, add 20 ...

Embodiment 2

[0066] Using the same polymerization method as in Example 1, with MPC, N-(3-aminopropyl) methacrylic acid hydrochloride (DPMA) and methacryloxyethyl dimethyl benzyl ammonium chloride (BDA) As a monomer, prepare a (meth)acrylic ester biomimetic polymer (2) containing phosphorylcholine zwitterions, amino hydrochloride and dimethyl benzyl ammonium chloride cations in side groups, only MPC, DPMA and BDA The molar percentage feeding ratio is 90:9:1, and the feeding amount is respectively 5.38g (18mmol) MPC, 0.36g (1.8mmol) DPMA and 0.06g (0.2mmol) BDA, and then three kinds of (formazan Base) acrylate monomer was dissolved in ethanol to obtain a monomer mixture; according to the mass percentage of initiator and (meth)acrylate monomer being 0.1:99.9, 0.0064g of azobisisobutyronitrile was weighed and dissolved in ethanol , to obtain an initiator solution; the monomer mixed solution and the initiator solution were mixed uniformly according to the mass percentage of 70:30, and transferr...

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Abstract

The invention discloses a bionic polymer and a method and application for making a durable double bionic polymer coating. The bionic polymer contains a zwitterionic group W, an amino hydrochloride S and a quaternary ammonium cationic group T in the side group. Dissolve the polymer and dopamine in a solvent in sequence to prepare a polymer-dopamine weakly alkaline aqueous solution. Then place different substrates in the polymer-dopamine weakly alkaline aqueous solution, rinse and dry to obtain a durable double biomimetic polymer coating. . The resulting coating has high light transmittance, good hydrophilicity, strong base material versatility, excellent coating stability, good anti-biomolecule adhesion and antibacterial properties, simple preparation process, one-step dip coating method is convenient, efficient, green and mild, and the material The surface has long-term resistance to biological contamination, resistance to bacterial infection and high biocompatibility. It is suitable for medical equipment, diagnostic and treatment instruments, implants, drug delivery systems of various shapes and materials, as well as contact lenses and corneas that require high light transmittance. Coating of surfaces such as shaping mirrors.

Description

Technical field [0001] The invention relates to the technical fields of polymer chemistry and physics, surface science and biomedical materials, and in particular to a bionic polymer and a method and application for making a durable double bionic polymer coating. Background technique [0002] With the widespread clinical use of medical equipment, diagnostic and treatment instruments, implants, etc. of various shapes and materials, bacterial infections related to them have become one of the most pressing clinical problems to be solved. The adhesion of bacteria to the material surface is the initial cause of this type of infection, and the amount of bacterial adhesion is closely related to factors such as the charge properties, hydrophilicity / hydrophobicity, chemical composition, and whether there is a biological contamination layer on the material surface. A large number of studies have shown that hydrophilic coatings rich in zwitterionic ions (electrically neutral) have a su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/04C08F230/02C08F220/36C08F220/34C08G73/06C09D143/02C09D133/14C09D5/14C09D5/16C08L23/12C08L27/18C08L69/00C08L83/04
Inventor 史素青赵洋张喜婷师欢陈杰范蓉瑾宫永宽
Owner NORTHWEST UNIV
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