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Preparation method for magnesium stearate

A technology of magnesium stearate and stearic acid, which is applied in the preparation of carboxylate, carboxylate, and organic compounds, etc., can solve the problems of high energy consumption, low yield, complex production process, etc., and achieve cost low cost, simple production process and high purity

Inactive Publication Date: 2015-11-11
NANTONG HAOYOU FOOD ADDITIVES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the highest domestically produced magnesium stearate is food grade, and very few of them have obtained medicinal standards. Grade magnesium stearate in short supply

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Dissolve 1 kg of stearic acid in 2 mL of chloroform as a solvent and recrystallize it, then wash it with chloroform to obtain stearic acid and dissolve it in 1.8 mL of chloroform as a solvent, raise the temperature to reflux, react for 2 hours, then wash with chloroform, and dry to obtain high-purity stearic acid;

[0015] Put 0.5kg of high-purity stearic acid, 0.28kg of magnesium sulfate, and 0.14kg of lye into the reaction kettle, add 3mL of purified water, stir and heat up, react at 90°C for 70min, dehydrate, add 0.5kg of absolute ethanol to fully dissolve;

[0016] Add 10 g / L iron-modified sepiolite adsorbent to the solution for oscillating adsorption for 3 hours, filter, recover ethanol under reduced pressure, wash the product thoroughly with purified water, dry and pulverize to obtain the finished product.

Embodiment 2

[0018] Dissolve 1 kg of stearic acid in 2.5 mL of chloroform as a solvent and recrystallize, then wash with chloroform to obtain stearic acid and dissolve it in 2 mL of chloroform as a solvent, heat up to reflux, react for 2 hours, then wash with chloroform, and dry to obtain high-purity stearic acid;

[0019] Put 0.5kg of high-purity stearic acid, 0.29kg of magnesium sulfate, and 0.15kg of lye into the reaction kettle, add 3mL of purified water, stir and raise the temperature, react at 80°C for 60min, dehydrate, add 0.5kg of absolute ethanol to fully dissolve;

[0020] Add 15g / L iron-modified sepiolite adsorbent to the solution for oscillating adsorption for 3 hours, filter, recover ethanol under reduced pressure, wash the product thoroughly with purified water, dry and pulverize to obtain the finished product.

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Abstract

The invention discloses a preparation method for magnesium stearate. The preparation method comprises the following steps: (1) dissolving stearic acid with chloroform as a solvent, performing recrystallization, washing through chloroform to obtain stearic acid, dissolving the obtained stearic acid with chloroform as a solvent, heating till reflux appears, enabling reaction for 1-2 h, washing with chloroform, and drying to obtain high-purity stearic acid; (2) placing the high-purity stearic acid, magnesium sulphate and a soda solution into a reaction still, adding purified water, stirring, heating, enabling reaction for 60-70 min at the temperature of 90-95 DEG C, dehydrating, adding anhydrous ethanol for sufficient dissolving; (3) adding a 10-20 g / L iron-modified sepiolite absorbent for batch adsorption for 2-3 h, filtering, recovering ethanol under reduced pressure, sufficiently washing the product with purified water, drying the washed product, and pulverizing to obtain the finished product. The magnesium stearate product provided by the invention is high in purity, meets medicinal grade requirements, and is simple in production technology and low in cost.

Description

technical field [0001] The invention relates to a preparation method of pharmaceutical excipients, in particular to a preparation method of magnesium stearate, which belongs to the technical field of fine chemicals. Background technique [0002] Magnesium stearate is white light and non-sandy fine powder, which has a greasy feeling in contact with the skin, and its molecular formula is Mg(C 17 h 35 COO) 2 , is widely used in the cosmetics, food and pharmaceutical preparation industries, mainly used as a lubricating release agent for tablets, and can also be used as an ingredient in cosmetics and as a stabilizer for polyvinyl chloride and paint in combination with calcium soap and zinc soap The drier has produced better social and economic benefits. However, at present, the highest domestically produced magnesium stearate is food grade, and very few of them have obtained medicinal standards. Grade magnesium stearate is in short supply. Contents of the invention [0003...

Claims

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Application Information

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IPC IPC(8): C07C53/126C07C51/42C07C51/41
CPCC07C51/42C07C51/412C07C53/126
Inventor 马鑫根
Owner NANTONG HAOYOU FOOD ADDITIVES
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