A kind of brucella bovis molecular marker vaccine strain and its application

A Brucella and molecular technology, applied in the direction of bacterial antigenic components, bacteria, antibacterial drugs, etc., can solve the problems of limited use of vaccines, weak immune protection of vaccines, etc., to strengthen the effect of immune prevention and control, and improve the effect of immune protection. Effect
CN105039233BActive Publication Date: 2018-10-23INNER MONGOLIA HUAXI BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INNER MONGOLIA HUAXI BIOTECH
Publication Date
2018-10-23

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Abstract

The invention discloses a brucella molecular marker vaccine strain for bovine species and an application thereof. The brucella molecular marker vaccine strain for bovine species, which is provided by the invention, is obtained by replacing the coding gene of a protein bp26 of brucella BH1 with the coding gene of a BLS protein and the coding gene of a protein L7 / L12 and inactivating the coding gene of a wboA protein of brucella. Experiments prove that the molecular marker vaccine strain BH1deltabp26deltawboA-BL has good immunoprotection effects on brucellosis, has lower toxicity and obviously improved safety, can be used for immunoprophylaxis of brucellosis of cattle and sheep, can distinguish wild strain infected animals from immune animals by adopting the immunological technique, has great significance in monitoring, diagnosing, purifying and controlling brucellosis and has extensive application value.
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Description

technical field

[0001] The invention belongs to the field of veterinary biological products, and in particular relates to a molecular marker vaccine strain of Brucella bovis and an application thereof. Background technique

[0002] Brucellosis (brucellosis) is a zoonotic infectious disease characterized by abortion and fever caused by Brucella. The disease is highly contagious and seriously threatens the lives and health of humans and various animals. The prevalence of brucellosis in my country is widespread and the harm is serious. Although a comprehensive and systematic defense against brucellosis has been carried out since the founding of New China, the epidemic situation of the disease has shown an obvious upward trend in recent years, and it has been listed as an infectious disease that is raging again. , arousing great concern in various regions of the country.

[0003] At present, the attenuated live vaccines used for the prevention and control of brucellosis mainly i...

Claims

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