Preparation method of disinfecting material namely methyl guanidine chitosan hydrochloride

A technology of methylguanidine salt and polyhexamethylene hydrochloric acid, applied in the field of chemical biology of renewable resources, to achieve significant sterilization, good sterilization and antibacterial effects, and excellent antivirus effects

Inactive Publication Date: 2015-11-18
SHANDONG HUIMIN LIJIE BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no graft copolymerization of polyhexamethylene guanidine hydrochloride and chitosan to form soluble methylguanidine hydrochl

Method used

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  • Preparation method of disinfecting material namely methyl guanidine chitosan hydrochloride
  • Preparation method of disinfecting material namely methyl guanidine chitosan hydrochloride

Examples

Experimental program
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Effect test

Embodiment 1

[0027] The preparation of embodiment 1 polyhexamethylene guanidine hydrochloride (PHGC)

[0028] Preparation of polyhexamethylene guanidine hydrochloride: Weigh 116.21 grams of 1,6-hexamethylenediamine and 95.53 grams of guanidine hydrochloride and melt and react at 120°C for half an hour. After NH3 is released, heat up to 180°C to continue the reaction for 3 hours, and then rapidly cool To room temperature, obtain white or milky white, no peculiar smell solid namely polyhexamethylene guanidine hydrochloride (PHGC).

Embodiment 2

[0029] The preparation of embodiment 2 salt polyhexamethylene guanidinium hydrochloride (PHGH)

[0030]The preparation of polyhexamethylene guanidine hydrochloride-glycidyl methacrylate polymer (PHGH): take by weighing 5.8 grams of polyhexamethylene guanidine hydrochloride and be dissolved in 50mL volume ratio of ethanol, acetone and In the mixed solution of water, weigh 4.3 grams of glycidyl methacrylate and dissolve it in 4 mL of acetone, mix the above two, stir and react at 40 ° C for 6 hours under the protection of nitrogen, and then rotary evaporate to obtain the product polyhexamethylene A polymer of guanidine hydrochloride-glycidyl methacrylate, namely polyhexamethylene guanidinium hydrochloride (PHGH).

Embodiment 3

[0031] The preparation of embodiment 3 methylguanidine hydrochloride chitosan

[0032] The preparation of methylguanidine hydrochloride chitosan: the salt polyhexamethylene guanidine hydrochloride (PHGH) of 0.69 gram is dissolved in the distilled water of 13.2mL equal substance quantity and acetic acid mixed solution, add 2.04 gram molecular weight and be 3-30 10,000 chitosan and stirred, after passing through N2 for 10 minutes, add 0.015 g of ammonium cerium nitrate, adjust the pH to 5-6 with 0.1 mg / L dilute nitric acid, stir and react in N2 atmosphere for 3 hours, and settle with acetone to obtain crude grafted product. Finally, it was extracted with ethanol for 8 hours, vacuum-dried, and ground to obtain 3.66 g of pure grafted product, ie methylguanidine hydrochloride chitosan.

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Abstract

The invention relates to a preparation method of a disinfecting material namely methyl guanidine chitosan hydrochloride, and belongs to the fields of renewable sources and chemical biology. According to the preparation method, the renewable resources namely chitosan and polyhexamethylene guanidine are used to prepare the disinfecting material. The preparation method comprises the following steps: preparing polyhexamethylene guanidine hydrochloride at first, reacting polyhexamethylene guanidine hydrochloride with glycidyl methacrylate to obtain a polyhexamethylene guanidine hydrochloride-glycidyl methacrylate polymer, and finally reacting the polyhexamethylene guanidine hydrochloride-glycidyl methacrylate polymer with chitosan to obtain methyl guanidine chitosan hydrochloride. The prepared methyl guanidine chitosan hydrochloride can be used as a disinfecting material, which can be used in hospitals, schools, hotels, vehicles, farms, and the like to disinfect the object surfaces and air.

Description

technical field [0001] The invention relates to a preparation method for synthesizing methylguanidine hydrochloride chitosan, a disinfection material, by utilizing natural renewable resources chitosan and polyhexamethylene guanidine, belonging to the field of chemical biology of renewable resources. Background technique [0002] Polyhexamethyleneguanidine has superior performance and is a new generation of bactericidal disinfectant. In 2002, it was included in the National Ministry of Health's "Disinfection Technical Specifications" commonly used disinfectant alternatives. Polyhexamethyleneguanidine, as an environmentally friendly and multi-purpose new cationic polymer, has an extremely wide range of uses in industry, agriculture, medicine and daily life. Polyhexamethyleneguanidine has high activity and strong affinity to microorganisms, so it is easily adsorbed by various bacteria, fungi, and viruses that are usually negatively charged, and quickly and comprehensively pene...

Claims

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Application Information

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IPC IPC(8): C08G81/00C08B37/08
Inventor 魏秀刚
Owner SHANDONG HUIMIN LIJIE BIOLOGICAL TECH CO LTD
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