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A kind of preparation method of oxidized cellulose external coating material

A technology of oxidized cellulose and concentrated solution, which is applied in the field of medical materials, can solve the problems of rare external application materials and no hemostatic effect of preparation methods, and achieve excellent hemostatic effect

Active Publication Date: 2018-02-16
镇江市君霖生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oxidized cellulose is currently widely used as a hemostatic agent in the medical field, which can play a good hemostatic effect, but currently there are few external application materials based on oxidized cellulose, and there is no better preparation method to enhance the hemostatic effect of the material

Method used

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  • A kind of preparation method of oxidized cellulose external coating material

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Comparison scheme
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Embodiment 1

[0017] A preparation method of oxidized cellulose external coating material, comprising the following steps:

[0018] Step 1: Take 10 parts by weight of Selaginella and 8 parts of Rubia, add water to decoct, the weight part of adding water is 100 parts, and decoct for 2 hours to obtain decoction 1;

[0019] Step 2, concentrating the decoction liquid 1 to obtain the concentrated liquid 1, the volume of the concentrated liquid 1 is 1 / 2 of that before concentration;

[0020] Step 3, add 1 part of calcium carbonate in parts by weight, 2-parts of hydroxyethyl starch, 5 parts of sodium carboxymethylcellulose, 2 parts of disodium edetate, and 50 parts of water in concentrated solution 1, Heating to 50°C under a vacuum condition with a vacuum degree of 0.01MPa, stirring for 50 minutes, and then concentrating to obtain the concentrated solution 2, the volume of the concentrated solution 2 is two-thirds of that before concentration;

[0021] Step 4: Add 20 parts by weight of oxidized c...

Embodiment 2

[0023] A preparation method of oxidized cellulose external coating material, comprising the following steps:

[0024] Step 1, take 12 parts by weight of Selaginella and 10 parts of Rubia, add water to decoct, the weight part of adding water is 105 parts, and decoct for 3 hours to obtain decoction 1;

[0025] Step 2, concentrating the decoction liquid 1 to obtain the concentrated liquid 1, the volume of the concentrated liquid 1 is 1 / 2 of that before concentration;

[0026] Step 3: Add 2 parts of calcium carbonate in parts by weight, 3 parts of hydroxyethyl starch, 6 parts of sodium carboxymethylcellulose, 3 parts of disodium edetate, and 60 parts of water in concentrated solution 1. Heating to 53°C under vacuum conditions with a vacuum degree of 0.02MPa, stirring for 70 minutes, and then concentrating to obtain Concentrate II, the volume of Concentrate II is two-thirds of that before concentration;

[0027] Step 4: Add 25 parts by weight of oxidized cellulose and 2 parts of d...

Embodiment 3

[0029] A preparation method of oxidized cellulose external coating material, comprising the following steps:

[0030] Step 1, take 17 parts by weight of Selaginella and 13 parts of Rubia, add water to decoct, the weight part of adding water is 110 parts, and decoct for 3 hours to obtain decoction 1;

[0031] Step 2, concentrating the decoction liquid 1 to obtain the concentrated liquid 1, the volume of the concentrated liquid 1 is 1 / 2 of that before concentration;

[0032] Step 3, add 3 parts by weight of calcium carbonate, 5 parts of hydroxyethyl starch, 8 parts of sodium carboxymethylcellulose, 3 parts of disodium edetate, and 70 parts of water in concentrated solution 1. Heating to 56°C under a vacuum condition with a vacuum degree of 0.03MPa, stirring for 80 minutes, and then concentrating to obtain the concentrated solution 2, the volume of the concentrated solution 2 is two-thirds of that before concentration;

[0033] Step 4: Add 29 parts by weight of oxidized cellulos...

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Abstract

The invention discloses a preparation method of an oxidized cellulose external application material. First, take 10-20 parts of Selaginella and 8-15 parts of Rubia in parts by weight, add water and decoct to obtain a decoction liquid, and then concentrate the decoction liquid , to obtain concentrated solution one; in concentrated solution one, add 1-4 parts of calcium carbonate in parts by weight, 2-6 parts of hydroxyethyl starch, 5-10 parts of sodium carboxymethylcellulose, ethylenediaminetetraacetic acid two 2-4 parts of sodium, 50-80 parts of water, heating and stirring under vacuum conditions for 50-100 minutes, and then concentrating to obtain concentrated liquid two; adding 20-30 parts of oxidized cellulose in parts by weight in concentrated liquid two, 1-4 parts of diethylaminoethyl methacrylate, stirred and mixed evenly, heated to 40-50°C, and left to stand for 150-200 minutes to obtain an oxidized cellulose external application material. The external application material obtained by the preparation method provided by the invention has a good hemostatic effect and can be better applied in the medical field.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a preparation method of an oxidized cellulose external application material. Background technique [0002] As the world pays more and more attention to the problems of environmental pollution and resource shortage, materials with biodegradability and environmental coordination have become a hot spot in the development of countries all over the world. Cellulose is the most abundant renewable natural polymer on earth and an inexhaustible organic resource in nature, and the cellulose material itself is non-toxic, water-resistant, biodegradable, and environmentally friendly Therefore, the use of cellulose as a matrix material and the development of cellulose derivatives have become a hot research topic at home and abroad. Cellulose derivatives, such as carboxymethyl cellulose and hydroxypropyl cellulose, are widely used in industry because of their biocompatibility, biod...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/44A61L15/28A61L15/18A61L15/20
Inventor 章祥庆唐海健
Owner 镇江市君霖生物科技有限公司