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Method for extracting biomarker for diagnosing pancreatic cancer, computing device therefor, biomarker for diagnosing pancreatic cancer and device for diagnosing pancreatic cancer including the same

A biomarker and pancreatic cancer technology, applied in biochemical equipment and methods, biostatistics, microbial measurement/testing, etc., can solve problems such as low sensitivity and specificity, lack of tissue specificity, and low practical diagnostic applicability , to achieve high specificity and high sensitivity

Active Publication Date: 2015-11-25
LG ELECTRONICS INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these protein biomarkers have rather low practical diagnostic utility due to their low sensitivity and specificity of about 60%
In particular, blood groups that lack tissue specificity and do not express Lewis antigens have the problem of not increasing CA19-9

Method used

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  • Method for extracting biomarker for diagnosing pancreatic cancer, computing device therefor, biomarker for diagnosing pancreatic cancer and device for diagnosing pancreatic cancer including the same
  • Method for extracting biomarker for diagnosing pancreatic cancer, computing device therefor, biomarker for diagnosing pancreatic cancer and device for diagnosing pancreatic cancer including the same
  • Method for extracting biomarker for diagnosing pancreatic cancer, computing device therefor, biomarker for diagnosing pancreatic cancer and device for diagnosing pancreatic cancer including the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Example 1. Calculation of correlation-based weights

[0086] The computing device 100 of the present invention can obtain correlation coefficients related to expression patterns of specific miRNAs and specific genes obtained through microarray testing, and can predict correlation coefficients between similar miRNAs similar to specific miRNAs and specific genes. Calculation of the correlation coefficient between similar miRNAs and specific genes will be described in detail with reference to the drawings described later.

[0087] Figure 4 is a conceptual diagram illustrating a method of calculating a correlation coefficient between similar miRNAs and specific genes using a similarity database, Figure 5 is a flowchart illustrating a method of calculating a correlation coefficient between similar miRNAs and specific genes using a similarity database.

[0088] First, after inputting experimental data including gene expression profiles and miRNA expression profiles obta...

Embodiment 2

[0093] Example 2. Calculation of correlations considering the interaction between miRNAs

[0094] The calculation device 100 of the present invention can calculate a correlation coefficient between a specific gene and adjacent miRNAs that form a cluster with a specific miRNA. From the description given below with reference to the accompanying drawings, it can be understood that the correlation calculation considering the mutual influence between miRNAs.

[0095] Image 6 is a conceptual diagram illustrating the method of calculating the correlation coefficient between adjacent miRNAs and specific genes using the miRNA clustering database, Figure 7 is a flowchart illustrating a method for calculating weights between adjacent miRNAs and specific genes using the miRNA clustering database.

[0096] First, after inputting experimental data including gene expression profiles and miRNA expression profiles obtained through microarray testing (S710), the control unit 140 calculate...

Embodiment 3

[0099] Example 3. Calculation of correlations taking transcription factors into account

[0100] The calculation device 100 of the present invention calculates a correlation coefficient in consideration of transcription factors between genes. Calculation of the correlation coefficient considering transcription factors between genes will be described with reference to the drawings given later.

[0101] Figure 8 is a conceptual diagram illustrating a method of calculating a correlation coefficient between a specific miRNA and a transcriptional regulatory gene using a transcription factor database, Figure 9 is a flowchart illustrating a method for calculating weights between specific miRNAs and transcriptional regulatory genes using the transcription factor database.

[0102] First, after inputting experimental data including gene expression profiles and miRNA expression profiles obtained through microarray testing (S910), the control unit 140 may calculate correlations bet...

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Abstract

Disclosed are a method for extracting a biomarker for diagnosing pancreatic cancer, a computing device therefor, a biomarker for diagnosing pancreatic cancer and a device for diagnosing pancreatic cancer including the same. More particularly, disclosed are a method for extracting a biomarker for diagnosing pancreatic cancer using genes specifically expressed in pancreatic cancer patients or microRNAs obtained from blood or tissues paired with the genes, a computing device therefor, a biomarker for diagnosing pancreatic cancer and a device for diagnosing pancreatic cancer including the same.

Description

technical field [0001] The present invention relates to a method for extracting a biomarker for pancreatic cancer diagnosis, a computing device used for the method, a biomarker for pancreatic cancer diagnosis, and a device for pancreatic cancer diagnosis including the biomarker, and more particularly relates to the use of Method for extracting biomarker for diagnosing pancreatic cancer from microRNA (microRNA) obtained from blood or tissue, computing device used for the method, biomarker for diagnosing pancreatic cancer, and device for diagnosing pancreatic cancer comprising the biomarker . Background technique [0002] The pancreas is an organ having an exocrine function of secreting digestive enzymes that degrade sugars, fats, and proteins in ingested food, and an endocrine function of secreting hormones such as insulin and glucagon. [0003] Pancreatic cancer is a tumor mass composed of cancer cells arising in the pancreas, which generally refers to pancreatic duct adeno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68G01N33/574G06F19/10G16B40/00G16B20/00G16B20/30G16B35/00
CPCC12Q1/6886C12Q2600/158C12Q2600/178G01N33/57438G06F19/18G06F19/24G16B20/00G16B40/00G16B35/00G16C20/60G16B20/30
Inventor 崔亨硕许智渊崔龙镇鱼海锡
Owner LG ELECTRONICS INC