Loxoprofen sodium coating agent and preparation method thereof

A technology of loxoprofen sodium and film coating agent, which is applied in the field of film coating agent preparation, can solve the problems such as the preparation of loxoprofen sodium film coating agent which has not been seen, and achieves improved bioavailability, less breakage, and enhanced curative effect. Effect

Inactive Publication Date: 2015-12-02
CHENGDU AIBIKE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage form currently used in clinic is mainly tablet, but

Method used

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Comparison scheme
Effect test

Embodiment

[0020] Loxoprofen sodium film-coating agent of the present embodiment, parts by weight represent, loxoprofen sodium 3g, chitosan 10g, glycerin 100g, laurocaprazine 5g, purified water 600ml, sufficient ethanol solution.

[0021] Wherein, the chitosan is a chitosan with a viscosity of 50 mPa·s and a deacetylation degree of not less than 80%; the ethanol solution is an ethanol solution with an ethanol concentration of 75%.

[0022] A preparation method of loxoprofen sodium film-coating agent, comprises the following steps:

[0023] (1) Take 600mL of purified water, scatter 10g of chitosan evenly on the surface of the purified water to make it swell naturally, then add 5g of laurocaprazine, stir evenly, and obtain a film-forming matrix;

[0024] (2) Take 100g of glycerin, add it to 300mL ethanol solution, then add 3g of loxoprofen sodium to dissolve it, and add it to the film-forming matrix in step (1);

[0025] (3) Add ethanol to 1000ml, and stir well to obtain loxoprofen sodium...

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Abstract

The invention discloses a loxoprofen sodium coating agent smeared on the surface of skin, relieve and cure rheumatoid arthritis, osteoarthritis, lumbago, scapulohumeral periarthritis, and diseases of shoulders, necks and wrists, and a preparation method of the loxoprofen sodium coating agent. The loxoprofen sodium coating agent comprises chitosan and glycerol, wherein chitosan is a deacetylation product of crustaceans, has favorable biocompatibility, film-forming property, bacterium resistance, inflammation resistance and hemostasis, and serves as a favorable auxiliary material for preparation of gelata; glycerol is taken as a plasticizer and humectant, and used for enabling a film to be high in elasticity and low in fracture possibility, and enhancing the percutaneous absorption of medicine; the coating agent made of glycerol and loxoprofen sodium can be used for overcoming the first pass effect of a liver and gastrointestinal tract effect, improving bioavailability and enhancing curative effect through local skin application. The coating agent has the advantages that the effect taking period is short; the effect is durable; the spreadability and the adhesive force are high; skin irritation is avoided; the drug delivery is convenient. The preparation method is relatively reasonable; the specificity of a content determination method is high; the result is accurate; the standards can be used for controlling the quality of the coating agent.

Description

technical field [0001] The invention relates to the technical field of preparation of film-coating agents, in particular to a film-coating agent of loxoprofen sodium and a preparation method thereof. Background technique [0002] Loxoprofen sodium is the first propionic acid precursor non-steroidal anti-inflammatory drug. It has strong analgesic effect, rapid onset, and balanced analgesic, anti-inflammatory, and antipyretic effects; it is safe to use and has few side effects. It is mainly used clinically for diseases such as rheumatoid arthritis, osteoarthritis, low back pain, frozen shoulder, neck, shoulder and wrist syndrome, and has a wide range of applications. The dosage form currently used in clinic is mainly tablet, but there is no preparation of loxoprofen sodium film-coating agent as yet. Contents of the invention [0003] The object of the present invention is to provide a kind of loxoprofen sodium coating agent that is applied on the skin surface to alleviate a...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/192A61K47/36A61P19/02A61P29/00
Inventor 何金蓉周洁
Owner CHENGDU AIBIKE BIOTECH
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