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Artificial blood vessel

A technology of artificial blood vessels and single fibers, applied in the field of artificial blood vessels, can solve the problems of insufficient practicability of artificial blood vessels, achieve the effects of inhibiting blood leakage from artificial blood vessels, reducing strength deterioration, and reducing the occurrence of thrombus

Inactive Publication Date: 2015-12-02
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when used as an artificial blood vessel with a small diameter (inner diameter less than 6mm), it is difficult to maintain the non-occlusive state for a long time due to thrombus formation, and the practicability as an artificial blood vessel for transplantation is still insufficient.

Method used

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  • Artificial blood vessel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] The warp and weft (back side yarns) use polyester fiber with a single fiber fineness of 1.38dtex and a total fineness of 33dtex multifilament yarn A; and a sea component polymer made of polyethylene terephthalate copolymerized with 5-sodium isophthalate Sea-island fiber composed of ethylene formate and island component polymer made of polyethylene terephthalate (ratio of sea / island (mass ratio)=20 / 80, island component number 70), single fiber fineness 7.3 dtex, total fineness 66dtex, untwisted multifilament yarn B'. The multifilament B'is formed into a multifilament B through an ultrafine treatment. Using the above warp yarns, for the multifilament yarn A and the multifilament B', respectively, the multifilament yarn A for a beam warping machine is used to make the warp weaving axis A, and the multifilament yarn B'is used to make the warp weaving axis B'. Using the above weft yarns, for the multifilament yarn A and the multifilament B', respectively, the multifilament y...

Embodiment 2

[0071] Except that the ratio of the multifilament yarn B was 75%, an artificial blood vessel including a tubular fabric was produced by the same method as in Example 1. When observing the inner wall surface of the obtained artificial blood vessel with a magnifying microscope of 100 times, it was confirmed that the multifilament yarn B formed loops and these loops existed in a dispersed state. In addition, the water permeability is 310ml / cm 2 / min, kink resistance, anti-thrombosis and cell adhesion get excellent results.

Embodiment 3

[0073] Except that the ratio of the number of single fibers of the multifilament yarn B was 30% and the wall thickness was 100 μm, an artificial blood vessel including a tubular fabric was produced by the method described in Example 1. When observing the inner wall surface of the obtained artificial blood vessel with a magnifying microscope of 100 times, it was confirmed that the multifilament yarn B formed loops and these loops existed in a dispersed state. Water permeability is 190ml / cm 2 / min, kink resistance has good results, antithrombotic properties are excellent, and cell adhesion has practical results.

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Abstract

The purpose of the present invention is to provide an artificial blood vessel that is able to maintain the mechanical characteristics of an artificial blood vessel, that is resistant to thrombus formation when grafted into a blood vessel of small diameter or medium diameter, and that has outstanding cell fixation properties to afford ready cell fixation and rapid endothelial tissue growth. The present invention provides an artificial blood vessel comprising a tubular fabric having at least two types of polyester fiber, i.e., a multifilament yarn A having a single fiber denier of 1.0 dtex or greater and a total denier of 33 dtex or less, and a multifilament yarn B having a single fiber denier of 0.08 dtex or less and a total denier of 66 dtex or less, and having an inside diameter of 8 mm or less and a wall thickness of 50 μm-250 μm, the multifilament yarn B forming loops on the inner wall surface of the composite tubular fabric.

Description

Technical field [0001] The present invention relates to an artificial blood vessel in which the occurrence of occlusion caused by thrombus when transplanted into a small-caliber blood vessel is suppressed while maintaining mechanical properties. Background technique [0002] Artificial blood vessels are mainly used to replace diseased biological blood vessels or form bypasses. Therefore, the artificial blood vessel requires: good biocompatibility with the host, no toxicity, etc., not easy to deteriorate in the body, strong, less blood leakage, anti-thrombotic, and not too expensive. [0003] As artificial blood vessels, there are cloth artificial blood vessels, polytetrafluoroethylene artificial blood vessels, bio-material-derived artificial blood vessels, synthetic polymer material artificial blood vessels, hybrid artificial blood vessels, etc., which are selected according to the application. For example, large-diameter (inner diameter 10mm or more) artificial blood vessels for ...

Claims

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Application Information

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IPC IPC(8): A61F2/06
CPCA61F2/06A61F2210/0066A61F2210/0071A61F2250/0017A61F2250/0039A61F2250/0067A61L27/18A61L33/068D04B21/02D10B2509/06C08L79/02A61F2/89A61F2210/0076
Inventor 山田谕土仓弘至田中伸明棚桥一裕阪口有佳藤田雅规门胁功治
Owner TORAY IND INC
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