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A method for removing endotoxin and impurity ions in deuterium-depleted washing target water

A technology of impurity ions and target washing water, applied in chemical instruments and methods, water/sewage multi-stage treatment, water/sludge/sewage treatment, etc., can solve the problem of increased product conductivity, difficult process control, increased deuterium abundance, etc. Problems, to achieve the effect of small loss of raw materials, small replacement frequency, and easy operation

Active Publication Date: 2017-04-05
SHANGHAI RES INST OF CHEM IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The activated carbon used in the activated carbon adsorption method needs to be filtered, and the membrane bag used needs to be replaced frequently, and the endotoxin in the activated carbon may be released, resulting in a rebound of the endotoxin content. The whole process is not easy to control; sedimentation filtration can remove certain endotoxins, but It is generally suitable for the treatment of relatively large amounts of water, and cannot meet the requirements of endotoxin content in water for injection; commonly used disinfection methods such as chlorine, ozone, and ultraviolet rays will lead to an increase in the conductivity of deuterium-depleted washing target water, and the chlorine disinfection method itself is dangerous. It will also introduce impurity ions, which will lead to excessive chloride ion content in the product
[0010] Since the deuterium-depleted target water is easy to absorb carbon dioxide in the air, the conductivity of the product will increase; it is easy to introduce bacteria and air-suspended substances in the air, and it is easy to exchange with water vapor in the air, resulting in the abundance of deuterium in the deuterium-depleted target water. Therefore, there is no simple method for removing endotoxin from deuterium-depleted washing target water under the premise of not increasing the deuterium abundance and not introducing impurity ions into the final product.

Method used

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  • A method for removing endotoxin and impurity ions in deuterium-depleted washing target water

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Experimental program
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Effect test

Embodiment 1

[0034] Processing method reference figure 1 The process flow shown.

[0035] Industrially produced low-deuterium washing target water, deuterium abundance is 5ppm, endotoxin content is 25EU / ML, conductivity is 3μs / cm, sodium hydroxide with a purity of 99.6% is added to make 0.5mol / L sodium hydroxide solution, put it into a distilled water generator with a purity of 99.999% high-purity argon as a protective gas for one distillation, then introduce the primary distillate into a distilled water generator with a purity of 99.999% high-purity argon as a protective gas, and Add phosphorus pentoxide with a purity of 99.99% to prepare a 0.5mol / L phosphoric acid solution, and carry out secondary distillation. The resulting secondary distillate is passed through ultrafiltration of polyether maple material with a molecular weight cut-off of 3000 and a membrane area of ​​200 square centimeters. Membrane package, the endotoxin is less than 0.01EU / ML, the conductivity is 0.21μs / cm, and the...

Embodiment 2

[0037] Industrially produced deuterium-depleted target washing water has a deuterium abundance of 25ppm, an endotoxin content of 20EU / ML, and a conductivity of 4.1μs / cm. Add sodium hydroxide with a purity of 99.6% to make 0.2mol / L hydroxide Sodium solution, put it into a distilled water generator with a purity of 99.999% argon as a protective gas for one distillation, and then put the primary distillate into a distilled water generator with a purity of 99.999% argon as a protective gas , and add phosphorus pentoxide with a purity of 99.99% to prepare a 1mol / L phosphoric acid solution, and carry out secondary distillation. Ultrafiltration membrane package, the endotoxin is less than 0.05EU / ML, the conductivity is 0.2μs / cm, and the deuterium abundance is 25ppm deuterium washing target water.

Embodiment 3

[0039]Industrially produced low-deuterium washing target water, deuterium abundance is 100ppm, endotoxin content is 25EU / ML, conductivity is 3.5μs / cm, sodium hydroxide with a purity of 99.6% is added to make 0.2mol / L hydroxide Sodium solution, put it into a distilled water generator with a purity of 99.999% argon as a protective gas for one distillation, and then put the primary distillate into a distilled water generator with a purity of 99.999% argon as a protective gas , and add phosphorus pentoxide with a purity of 99.99% to prepare a 0.5mol / L phosphoric acid solution, and perform secondary distillation. Ultrafiltration membrane package, the endotoxin is lower than 0.01EU / ML, the conductivity is 0.10μs / cm, and the deuterium abundance is 100ppm deuterium washing target water.

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Abstract

The invention relates to a method for removing endotoxin and foreign ions in low-deuterium target washing water. The method comprises steps: removing part of endotoxin and foreign ions in low low-deuterium target washing water raw material with two-level distilling, and filtering and removing residual endotoxin in the low-deuterium target washing water with an ultrafiltration membrane. Compared with prior art, under the premise that abundance of deuterium (D) is not increased in the low-deuterium target washing water and other foreign ions are not introduced in a final product, part of endotoxin and foreign ions in the low-deuterium target washing water are removed by the two-level distilling, and then most endotoxins and foreign ions in the low-deuterium target washing water are removed by the ultrafiltration membrane, thus realizing that the endotoxin and foreign ions in the low-deuterium target washing water are up to standard. The method is simple and convenient, guarantees products quality and consumes less low-deuterium target washing water.

Description

technical field [0001] The invention relates to a treatment method for deuterium-depleted washing target water, in particular to a method for removing endotoxin and ions in deuterium-depleted washing target water. Background technique [0002] In Positron Emission Computed Tomography (PET), bombardment with a cyclotron is required 18 O to obtain fluorine-18 ions, and then prepare radiopharmaceuticals for injection into the human body through nucleophilic substitution reactions with non-radioactive materials. The cleanliness and ion content of the target film bombarded in the cyclotron used are related to the recovery rate of the drug; the target film is expensive, and the impurities remaining on the surface after bombardment are easy to cause corrosion and reduce its service life, so it must be regularly checked. Cleans without any residue, while ordinary medical water does not clean well. [0003] Deuterium-depleted target washing water is a reagent specially used to clea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C02F9/10
Inventor 谷宏森周建跃肖斌秦川江刘严李猷林轶凡池毅蒋琮琪王杰
Owner SHANGHAI RES INST OF CHEM IND