Composition with anti-gastric cancer effect and application thereof

A composition and technology for gastric cancer, applied in the field of medicine, can solve the problems of leukopenia, thrombocytopenia, etc., and achieve the effects of low adverse reactions, promotion of cell damage, and strong anti-gastric cancer activity

Inactive Publication Date: 2018-11-06
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, 5-fluorouracil has certain side effects during clinical use, such as bone marrow suppression, leukopenia, and thrombocytopenia, as well as gastrointestinal reactions such as loss of appetite, nausea, vomiting, stomatitis, gastritis, abdominal pain, and diarrhea.
These side effects limit its clinical application to some extent

Method used

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  • Composition with anti-gastric cancer effect and application thereof
  • Composition with anti-gastric cancer effect and application thereof
  • Composition with anti-gastric cancer effect and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A composition with anti-gastric cancer effect, which is made of the following raw materials in parts by weight:

[0027] 0.0195 parts of 5-fluorouracil, 10 parts of the water extract of the traditional Chinese medicine composition.

[0028] The preparation method of the Chinese medicine composition water extract is: get cooked rhubarb 300g, leech (system) 60g, grub (fried) 45g, walnut kernel 120g, scutellaria baicalensis 60g, Radix Paeoniae Alba 120g, ground beetle (fried) 30g, horsefly worm (dewing) foot, fried) 45g, dry lacquer (calcined) 30g, fried bitter almond 120g, rehmannia glutinosa 300g, licorice 90g, pulverized into fine powder, sieved, mixed, every 100g of powder with 80~100g of refined honey to make small honey pills or Big honey pills, fully dissolved in ultra-pure water before use, overnight at 4°C, filter-sterilized, and stored at 4°C until use.

Embodiment 2

[0030] A composition with anti-gastric cancer effect, which is made of the following raw materials in parts by weight:

[0031] 0.0195 parts of 5-fluorouracil, 5 parts of water extract of Chinese medicine composition.

[0032] The preparation method of the Chinese medicine composition water extract is: get cooked rhubarb 300g, leeches (system) 60g, grubs (fried) 45g, peach kernel 120g, scutellaria baicalensis 60g, Radix Paeoniae Alba 120g, ground beetle (fried) 30g, horsefly worm (dewing) foot, fried) 45g, dry lacquer (calcined) 30g, fried bitter almond 120g, rehmannia glutinosa 300g, licorice 90g, pulverized into fine powder, sieved, mixed, every 100g of powder with 80~100g of refined honey to make small honey pills or Big honey pills, fully dissolved in ultra-pure water before use, overnight at 4°C, filter-sterilized, and stored at 4°C until use.

Embodiment 3

[0034] 0.0195 parts of 5-fluorouracil, and 2.5 parts of the water extract of the traditional Chinese medicine composition.

[0035] The preparation method of the Chinese medicine composition water extract is: get cooked rhubarb 300g, leeches (system) 60g, grubs (fried) 45g, peach kernel 120g, scutellaria baicalensis 60g, Radix Paeoniae Alba 120g, ground beetle (fried) 30g, horsefly worm (dewing) foot, fried) 45g, dry lacquer (calcined) 30g, fried bitter almond 120g, rehmannia glutinosa 300g, licorice 90g, pulverized into fine powder, sieved, mixed, every 100g of powder with 80~100g of refined honey to make small honey pills or Big honey pills, fully dissolved in ultra-pure water before use, overnight at 4°C, filter-sterilized, and stored at 4°C until use.

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Abstract

The invention provides composition with a gastric cancer resistance function and an application of the composition. The composition comprises 5-fluorouracil and traditional Chinese medicine composition, wherein the traditional Chinese medicine composition comprises prepared rhubarb, leeches, stir-fried grubs, peach kernels, baical skullcap roots, white paeony roots, ground beetles, gadflies, calcined dried lacquer, stir-fried bitter apricot seeds, rehmannia roots and liquorice. The traditional Chinese medicine composition with scientific and reasonable component proportioning is screened out according to a medicine prescription compatibility theory of China on the basis of a large quantity of experimental researches. The composition can promote apoptosis of gastric cancer cells, inhibit a DNA (deoxyribonucleic acid) synthesis stage of AGS, perform a cell killing function by influencing caspase 3 and promote cell damage by inducing cells to generate iNOS; the traditional Chinese medicine composition has a very good synergistic interaction function, is higher in gastric cancer resistance activity and causes fewer adverse reactions after being combined with 5-FU (5-fluorouracil), and the composition combining the traditional Chinese medicine composition with 5-FU has higher drug safety than 5-FU used independently.

Description

technical field [0001] The invention relates to a medicine, specifically a composition with an anti-gastric cancer effect and the application of the composition in preparing an anti-gastric cancer medicine. Background technique [0002] 5-Fluorouracil is a synthetic anti-metabolite and is currently the most widely used anti-pyrimidine drug in clinical practice. It has good curative effect on digestive tract cancer and other solid tumors, and plays an important role in medical oncology treatment. 5-fluorouracil has antitumor activity through enzymatic conversion to 5-fluorodeoxyuridine nucleotides. 5-FU inhibits DNA synthesis by inhibiting thymidine nucleotide synthetase. The action of this enzyme may transfer the one-carbon unit of leucovorin to deoxyuridine-phosphate to synthesize thymidine. 5-FU also has a certain inhibitory effect on RNA synthesis. Clinically, it has a good curative effect on a variety of tumors, such as digestive tract tumors, breast cancer, ovarian c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61P35/00A61K35/64A61K35/62A61K31/513
Inventor 董伟詹瑧吴建平张伟伟许冬青陈颖张军峰姜淼
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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