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Compound of propranolol or medicinal salt thereof and ion exchange resin and suspension of compound

A technology of ion exchange resin and medicinal salt, which is applied in the direction of drug combination, antineoplastic drugs, liquid delivery, etc. It can solve problems such as darkening of color, increase of related substances, and obvious numbness in the mouth, so as to improve stability and drug loading. Large amount, the effect of solving numbness

Inactive Publication Date: 2015-12-23
科贝源(北京)生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this product has added a large amount of correctives and sweeteners, the bitter taste of propranolol is still relatively obvious, and the numbness of the oral cavity is obvious after taking it, and it is placed under light conditions for 10 days, the color of the solution becomes darker, and related substances Increase

Method used

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  • Compound of propranolol or medicinal salt thereof and ion exchange resin and suspension of compound
  • Compound of propranolol or medicinal salt thereof and ion exchange resin and suspension of compound
  • Compound of propranolol or medicinal salt thereof and ion exchange resin and suspension of compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]

[0040] Preparation process: take the prescribed amount of purified water, add the prescribed amount of propranolol hydrochloride, stir to dissolve, add the prescribed amount of polycridine, stir for 1 hour, and obtain.

Embodiment 2

[0042]

[0043] Preparation process: take the prescribed amount of purified water, add the prescribed amount of propranolol hydrochloride, stir to dissolve, add the prescribed amount of pocridine potassium, and stir for 1 hour to obtain.

Embodiment 3

[0045]

[0046] Preparation process: take the prescribed amount of purified water, add the prescribed amount of propranolol hydrochloride, stir to dissolve, add the prescribed amount of sodium polystyrene sulfonate, stir for 1 hour, and obtain.

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PUM

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Abstract

The invention relates to a compound of propranolol or a medicinal salt thereof and ion exchange resin and a preparation method of the compound. The compound comprises propranolol and a salt thereof and ion exchange resin, wherein the ion exchange resin is selected from one or more of polacrilin (polacrilin), polacrilin potassium (polacrilin potassium) and sodium polystyrenesulfonate. The compound of the propranolol and the salt thereof provided by the invention can be further prepared into an oral preparation, especially an oral suspension; the bitter taste and the thrill of a propranolol medicine solution can be removed; meanwhile, the stability of the compound is greatly improved; harmful impurities are reduced when the taking compliance is improved; the product quality is improved; and the medication safety of a patient is ensured.

Description

technical field [0001] The invention relates to a compound of propranolol or its pharmaceutically acceptable salt and ion exchange resin and its suspension, belonging to the field of pharmaceutical preparations. Background technique [0002] Infantile hemangioma (IH) is the most common benign tumor in infancy. The incidence of hemangioma at birth is 1.1% to 2.6%, and the incidence can be as high as 10% to 12% within one year of age. 85% to 90% of hemangiomas can regress spontaneously without special treatment, but some hemangioma growth sites may affect the appearance, affect the function of the body and even endanger life, and require active treatment. There are many traditional treatment methods, such as freezing, isotope sticking, laser, drug treatment, surgical excision and skin grafting, etc., all of which have certain therapeutic effects, but all have different degrees of side effects or treatment risks. [0003] Since the first report of oral propranolol for the tre...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K9/10A61K31/138A61P35/00A61P9/06A61P9/04A61P9/12
Inventor 满艳哲张建维
Owner 科贝源(北京)生物医药科技有限公司