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A method for the determination of formaldehyde content in N-hydroxymethylmethionine calcium product

A technology for the content of calcium hydroxymethylmethionine and formaldehyde, which is applied in the preparation of test samples, chemical analysis by titration, color/spectral characteristic measurement, etc., can solve the problem of poor reproducibility of measurement results, inability to accurately measure, and reproducibility Poor performance and other problems, to achieve high accuracy, easy operation, good reproducibility

Active Publication Date: 2018-05-08
NINGXIA UNISPLENDOUR TIANHUA METHIONINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, in the published literature, the determination of the formaldehyde content in N-hydroxymethylmethionine calcium products is to first use the chromogenic agent to develop the color and then use the spectrophotometric method to measure it. For example, in "China Feed Additives" 2010 In the first phase, the spectrophotometric method was used to measure the formaldehyde in the sample after using chromic acid to develop color.
In addition, through experiments, it was found that other conventional methods for the determination of formaldehyde, such as spectrophotometric determination after color development with other chromogens, or acid-base titration after the addition of sodium sulfite, all have reproducibility Poor, unable to measure accurately and other technical problems

Method used

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  • A method for the determination of formaldehyde content in N-hydroxymethylmethionine calcium product
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  • A method for the determination of formaldehyde content in N-hydroxymethylmethionine calcium product

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Embodiment 1

[0030] A method for assaying formaldehyde content in N-hydroxymethylmethionine calcium product, it is specifically carried out according to the following steps:

[0031] 1) Weigh 3g of potassium permanganate, add it into a mixture containing 15mL of sulfuric acid solution with a mass percentage concentration of 85% and 70mL of water, and dissolve it completely, then add water to 100mL to obtain potassium permanganate-sulfuric acid solution ; Weigh 7 g of dihydrate crystalline oxalic acid, and dissolve it in a phosphoric acid solution with a volume ratio of 1:1 to 100 mL to obtain an oxalic acid-phosphoric acid solution;

[0032] 2) Accurately weigh 0.2015g of the N-hydroxymethylmethionine calcium product as the sample to be tested, place it in a 250mL iodine flask, add 20mL of water and 5mL of the potassium permanganate-sulfuric acid solution obtained in the above step 1), and shake well , seal it tightly with water, shake it well to dissolve it, and then place it in a water b...

Embodiment 2

[0040] A method for assaying formaldehyde content in N-hydroxymethylmethionine calcium product, it is specifically carried out according to the following steps:

[0041] 1) Weigh 3g of potassium permanganate, add it into a mixture containing 15mL of sulfuric acid solution with a mass percentage concentration of 85% and 70mL of water, and dissolve it completely, then add water to 100mL to obtain potassium permanganate-sulfuric acid solution ; Weigh 7 g of dihydrate crystalline oxalic acid, and dissolve it in a phosphoric acid solution with a volume ratio of 1:1 to 100 mL to obtain an oxalic acid-phosphoric acid solution;

[0042] 2) Accurately weigh 0.2128g of the N-hydroxymethylmethionine calcium product as the sample to be tested, place it in a 250mL iodine flask, add 20mL of water and 5mL of the potassium permanganate-sulfuric acid solution obtained in the above step 1), and shake well , seal it tightly with water, shake it well to dissolve it, and then place it in a water b...

Embodiment 3

[0049] Embodiment 3 (accuracy verification)

[0050] A method for determining the content of formaldehyde in N-hydroxymethylmethionine calcium products, the sample to be tested is selected from purchased, known methionine weight percentage is 67.70%, formaldehyde weight percentage is 13.58 % calcium N-hydroxymethylmethionine 0.2g, weigh accurately to 0.0001g and measure, its mensuration and calculation method are identical with embodiment 1; The result records that the weight percent composition of formaldehyde in the sample to be tested is 13.59%. The above results illustrate: measure the formaldehyde content in the N-hydroxymethylmethionine calcium of known accurate content by the inventive method, and its measurement result is consistent with label content, promptly shows that this method is accurate.

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Abstract

The invention relates to a method for determining the formaldehyde content in an N-hydroxymethyl methionine calcium product. According to the determining method, an excessive amount of oxidizing agent potassium permanganate is added into an acid solution, the N-hydroxymethyl methionine calcium product is added into the potassium permanganate acid solution, then a reducing agent is added till the acid solution is completely faded, and then determination is performed by adopting a conventional formaldehyde content determining method. The method has the advantages of being good in reproducibility, high in accuracy, simple and convenient to operate and the like and can be used for quality control of the N-hydroxymethyl methionine calcium product.

Description

technical field [0001] The invention relates to the determination of formaldehyde content in N-hydroxymethylmethionine calcium, in particular to a method for determining the formaldehyde content in N-hydroxymethylmethionine calcium products. Background technique [0002] Calcium N-hydroxymethylmethionine, chemical name N-hydroxymethyl-methylthiobutyrate calcium, also known as protective methionine, is a free-flowing white powder. It can be used as a feed additive to supplement the insufficient amount of methionine in the diet of ruminants, exert the nutritional function of methionine, and improve its utilization rate of methionine. After being added to the diet of dairy cows, it can increase milk production, milk fat rate and milk protein content, and prolong the milk production period. In industry, formaldehyde is often used to hydroxymethylate DL-methionine, and then neutralize it with calcium hydroxide or calcium oxide. In order to ensure product quality, in 1987 the Mi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N1/28G01N31/16G01N21/25
Inventor 罗延谷胡欣何咏梅刘兵
Owner NINGXIA UNISPLENDOUR TIANHUA METHIONINE CO LTD