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Preparation for treating cardiovascular and cerebrovascular diseases

A technology for cardiovascular and cerebrovascular diseases and preparations, applied in the field of preparations for the treatment of cardiovascular and cerebrovascular diseases, to achieve the effects of increasing stability, overcoming the decline in drug efficacy, and improving compliance

Active Publication Date: 2015-12-30
成都阿奇生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far no one has proposed to directly use the dehydrodhydrodrysoline hydrochloride obtained by the synthetic method to make a medicine alone or to be combined with other medicines to form a medicine for treating cardiovascular and cerebrovascular diseases.

Method used

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  • Preparation for treating cardiovascular and cerebrovascular diseases
  • Preparation for treating cardiovascular and cerebrovascular diseases
  • Preparation for treating cardiovascular and cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The preparation of embodiment 1 pharmaceutical tablet of the present invention

[0042] prescription:

[0043]

[0044] operate:

[0045] Weigh the crushed and sieved 80-mesh dehydrodacaryline hydrochloride, starch, dextrin, and lactose according to the prescription amount, mix thoroughly, take PVP, add distilled water to heat to make a 5% solution, and add it to the mixed powder to make The soft material is granulated with a 20-mesh sieve, dried at 60°C for 4 hours, granulated with an 18-mesh sieve, mixed with magnesium stearate, and compressed to obtain tablets.

Embodiment 2

[0046] The preparation of embodiment 2 pharmaceutical capsules of the present invention

[0047]

[0048] operate:

[0049] Weigh the crushed and sieved 80-mesh dehydrodacaryline hydrochloride, starch, dextrin, and lactose according to the prescription amount, mix thoroughly, take PVP, add distilled water to heat to make a 5% solution, and add it to the mixed powder to make The soft material is granulated with a 20-mesh sieve, dried at 60°C for 4 hours, granulated with an 18-mesh sieve, mixed with magnesium stearate, filled into capsules, and obtained.

Embodiment 3

[0050] The preparation of embodiment 3 drug slow-release tablets of the present invention (making 1000):

[0051]

[0052] Weigh the crushed and sieved 80-mesh dehydrodacaryline hydrochloride, starch, dextrin, lactose, and ethyl cellulose according to the prescription. After mixing thoroughly, take PVP, add distilled water and heat to make a 5% solution, add The mixed powder is made into a soft material, granulated with a 20-mesh sieve, dried at 60°C for 4 hours, granulated with an 18-mesh sieve, mixed with magnesium stearate, and pressed into tablets.

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Abstract

The invention provides a preparation and sustained release preparation for treating cardiovascular and cerebrovascular diseases. According to the prepared dehydrocorydaline chloride preparation, the releasing rate of dehydrocorydaline chloride is improved, and the drug stability is improved; in addition, according to dehydrocorydaline chloride sustained release tablets, the suitable plasma concentration can be supplied to a human body in the scheduled period as needed, the taking times can be decreased, and the good treating effect can be achieved. The preparation for treating the cardiovascular and cerebrovascular diseases has the advantages that the human body can maintain the blood concentration for a longer time, the blood concentration cannot be decreased quickly as ordinary preparations, therefore, the peak valley phenomenon caused by frequent drug administration of the ordinary preparations can be avoided, and the safety, effectiveness and adaptability of the preparation can be improved; the defect that the drug curative effect is reduced due to fluctuation of the plasma drug concentration is overcome, the long-time stable plasma concentration is maintained, the patient compliance is improved, and the clinical curative effect of the preparation is guaranteed.

Description

technical field [0001] The invention relates to a preparation for treating cardiovascular and cerebrovascular diseases. Background technique [0002] Dehydrocorydalinechloride is a berberine-type alkaloid contained in Corydalis Corydalis, and its chemical name is 13-methyl-7,8,13,13 a -Tetradehydro-2,3,9,10 tetramethoxy orthobasic (13-methyl-7,8,13,13 a -tetradehydro-2,3,10-tetramethoxyberhine), the structural formula is: [0003] [0004] The alkaloid is one of the effective components of Corydalis Corydalis for treating coronary heart disease. Modern pharmacological tests show that it can significantly prolong the survival time of animals under hypoxic conditions, and can increase the myocardial 86 The uptake rate of Rb can increase the amount of nutritional blood loss in the myocardium of mice, and the clinical effect has been initially seen. Sun Liuyan et al. have reviewed the pharmacological effects of DHC and its research progress at the cellular molecular level....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/20A61K9/36A61K9/32A61K9/48A61K31/4375A61P9/10
Inventor 石万棋王安生任娅莉钟光俊徐琨
Owner 成都阿奇生物医药科技有限公司