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Calcium carbonate D3 tablet and preparation method thereof

A technology of calcium carbonate and calcium carbonate powder, which is applied in pharmaceutical formulations, active ingredients of aluminum/calcium/magnesium, medical preparations containing active ingredients, etc., can solve problems such as inconvenient taking, large volume, and inconvenient taking, and achieve reduction The effect of tablet weight and volume, strong operability and stable quality

Inactive Publication Date: 2016-01-06
WUXI FORTUNE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese invention patent application CN102716149A discloses "a kind of calcium carbonate D 3 Effervescent Tablet and Preparation Method thereof", all have defects such as inconvenient taking
[0008] At present, calcium carbonate D on the market 3 Tablets are relatively large in size, and each tablet weighs about 1.8g, which is inconvenient to take. In order to overcome the above-mentioned defects, the prescription composition of the present invention can reduce the tablet weight to 1.4g without losing active ingredients

Method used

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  • Calcium carbonate D3 tablet and preparation method thereof
  • Calcium carbonate D3 tablet and preparation method thereof
  • Calcium carbonate D3 tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Prescription 1 (specification 500mg / 200IU)

[0034]

[0035]

[0036] Preparation method: mix calcium carbonate powder with microcrystalline cellulose 101, add 100ml of purified water to obtain soft material, and pass the soft material through a 30-mesh sieve to obtain wet granules. The wet granules are placed in a drying oven, and the temperature is adjusted to 60° C. for drying treatment so that the moisture content of the wet granules is reduced to 1% to 2% of the dry granules, and the granules are sized using a 40-mesh sieve. Vitamin D 3 The powder is crushed and passed through a 100-mesh sieve. Combine dry granules of calcium carbonate with vitamin D 3 Powder, microcrystalline cellulose 102, croscarmellose sodium, and magnesium stearate are mixed evenly, and pressed into tablets to obtain the product. Among them, microcrystalline cellulose 102, croscarmellose sodium and magnesium stearate all pass through a 100-mesh sieve. Preferably, in Example 1, the pa...

Embodiment 2

[0038] Prescription 2 (specification 500mg / 200IU)

[0039]

[0040]Preparation method: mix calcium carbonate powder with pregelatinized starch, add 120ml of purified water to make soft material. Pass the soft material through a 30-mesh sieve and granulate to obtain wet granules. The wet granules are placed in a drying oven, and the temperature is adjusted to 65° C. to dry until the moisture in the dry granules is reduced to 1% to 2%, and the dry granules are passed through a 40-mesh sieve for sizing. Vitamin D 3 The powder is crushed and passed through a 100-mesh sieve. Calcium Carbonate Dry Granules with Vitamin D 3 Powder, microcrystalline cellulose 102, croscarmellose sodium, and magnesium stearate are mixed evenly, and pressed into tablets to obtain the product. Among them, microcrystalline cellulose 102, croscarmellose sodium, and magnesium stearate were all passed through a 100-mesh sieve.

Embodiment 3

[0042] Prescription 3 (specification 500mg / 200IU)

[0043]

[0044] Preparation method: mix calcium carbonate powder with povidone, add 100ml of purified water and mix to make soft material. Granulate the soft material through a 30-mesh sieve to obtain wet granules. Put the wet granules in a drying oven, adjust the temperature to 70°C and dry until the moisture in the dry granules is reduced to 1% to 2%, sieve the granules with 40 mesh; vitamin D 3 The powder is crushed and passed through a 100-mesh sieve. Combine dry granules of calcium carbonate with vitamin D 3 Powder, microcrystalline cellulose 102, croscarmellose sodium, and magnesium stearate are mixed evenly, and pressed into tablets to obtain the product. Among them, microcrystalline cellulose 102, croscarmellose sodium, and magnesium stearate were all passed through a 100-mesh sieve.

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Abstract

The invention provides a calcium carbonate D3 tablet and a preparation method thereof. The calcium carbonate D3 tablet is prepared from the following components by weight: 1250g of calcium carbonate powder, 2g of vitamin D3 powder, 6.5g of a disintegrating agent, 1g of a lubricant and 170g of other pharmaceutically acceptable auxiliary materials, wherein the pharmaceutically acceptable auxiliary materials comprise microcrystalline cellulose 102; the content by weight of the microcrystalline cellulose 102 can reach up to 4%. Through the calcium carbonate D3 tablet and the preparation method thereof, the weight of the finally prepared calcium carbonate D3 tablet is about 1.4g; compared with the commercially available calcium carbonate D3 tablet which is 1.8g, the weight and the volume of the tablet can be reduced; the calcium carbonate D3 tablet is convenient to carry and swallow; all effective components of the calcium carbonate D3 tablet are uniform in content and stable in quality; meanwhile, the preparation method of the calcium carbonate D3 tablet is simple and practicable, and is high in operability; and the mass production of industrialization is facilitated.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, in particular to a calcium carbonate D for improving osteoporosis 3 Tablets and their preparation process. Background technique [0002] Statistics from the World Health Organization show that the current incidence of osteoporosis has jumped to the seventh place among the common frequently-occurring diseases in the world. Osteoporotic fractures will occur in older men, including more than 75 million in the United States, Western Europe, and Japan alone. With the formation of an aging society in my country, it is predicted that by 2050, the number of patients with osteoporosis, including osteopenia, will reach 2.12×10 8 For example, accounting for 13.2% of the total population. Osteoporosis will become a serious public health problem, especially in postmenopausal women. Due to ovarian hypofunction, the bone tissue volume per unit volume decreases faster, and the incidence of osteoporosis and f...

Claims

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Application Information

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IPC IPC(8): A61K33/10A61K9/20A61P19/10A61K31/593
Inventor 张惠芳李勇虞佳媛徐建国张莹
Owner WUXI FORTUNE PHARMA