Atractylenolide extract having antiparkinsonian effect, preparation method and application thereof

An atractylodes lactone and anti-Parkinsonian technology, applied in the field of traditional Chinese medicine, can solve the problems of no anti-Parkinsonian effect, easy volatilization, long time, etc. Effect

Inactive Publication Date: 2016-01-27
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The main component of the volatile oil in Atractylodes macrocephala is Atractylodes ketone. Research shows that Atractylodes atractylodes has no a...

Method used

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  • Atractylenolide extract having antiparkinsonian effect, preparation method and application thereof
  • Atractylenolide extract having antiparkinsonian effect, preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0030] This example provides an extract of Atractylodes macrolide with anti-Parkinson effect. The extract contains Atractylodes atractylodes I in a weight percentage of 7.5%, Atractylodes atractylodes II in a weight percentage of 12.3% and Atractylodes atractylodes The weight percent of ester III is 25.7%, and the purity of total lactones is 45.5% by weight.

[0031] This embodiment also provides a preparation method of Atractylodes lactone extract with anti-Parkinson effect, including the following steps.

[0032] Step 1. Take 50 g of Atractylodes macrocephala medicinal material, pulverize it, and pass through a 10-mesh sieve to obtain Atractylodes macrocephala powder.

[0033] Step 2. Use hydrogen peroxide to oxidize atractylone in Atractylodes macrocephala powder: use 50 mL of hydrogen peroxide with a volume percentage of 20%, infiltrate for 4 hours, and oxidize at 50° C. for 8 hours.

[0034] Step 3. After the oxidation of the Atractylodes macrocephala powder is completed...

Embodiment 2

[0087] This example provides an extract of Atractylodes macrolide with anti-Parkinson effect. The extract contains Atractylodes atractylodes I at a weight percentage of 8.3%, Atractylolide II at a weight percentage of 14.2% and Atractylodes atractylodes The weight percent of ester III is 27.2%, and the purity of total lactones is 49.7% by weight.

[0088] This embodiment also provides a preparation method of Atractylodes lactone extract with anti-Parkinson effect, including the following steps.

[0089] Step 1. Take 50 g of Atractylodes macrocephala medicinal material, pulverize it, and pass through a 20-mesh sieve to obtain Atractylodes macrocephala powder.

[0090] Step 2. Use hydrogen peroxide to oxidize atractylone in Atractylodes macrocephala powder: use 50 mL of hydrogen peroxide with a volume percentage of 30%, infiltrate for 3 hours, and oxidize at 40° C. for 6 hours.

[0091] Step 3. After the oxidation of the Atractylodes macrocephala powder is completed, it is drie...

Embodiment 3

[0096] This example provides an extract of Atractylodes macrolide with anti-Parkinson effect. The extract contains Atractylodes atractylodes I in a weight percentage of 8.7%, Atractylodes atractylodes II in a weight percentage of 11.1% and Atractylodes atractylodes The weight percent of ester III is 28.7%, and the purity of total lactones is 48.5% by weight.

[0097] This embodiment also provides a preparation method of Atractylodes lactone extract with anti-Parkinson effect, including the following steps.

[0098] Step 1. Take 50 g of Atractylodes macrocephala medicinal material, pulverize it, and pass through a 20-mesh sieve to obtain Atractylodes macrocephala powder.

[0099] Step 2. Oxidation of atractylone in Atractylodes macrocephala powder with hydrogen peroxide: use 100 mL of hydrogen peroxide with a volume percentage of 30%, infiltrate for 6 hours, and oxidize at 50° C. for 4 hours.

[0100] Step 3. After the oxidation of the Atractylodes macrocephala powder is compl...

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Abstract

The invention discloses atractylenolide extract having antiparkinsonian effect, a preparation method and application thereof. Weight percentages of atractylenolide I, atractylenolide II and atractylenolide III in the atractylenolide extract are larger than 5%, 10% and 20% respectively, and purity of total lactone is larger than 35%. The application refers to that the atractylenolide extract is used to prepare antiparkinsonian drug. The preparation method includes that oxidant is added into white atractylode rhizome powder, and atractylone in white atractylode rhizome volatile oil is oxidized into atractylenolide compounds, so that content of atractylenolide is increased; zinc particles are added into an extraction solution to protect generated compounds such as atractylenolide from being further oxidized and degraded. The preparation method is simple, convenient and practical, easy to operate and more suitable for industrial production, and has remarkable progressiveness and practical value.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to an extract of atractylodes lactone with anti-parkinson effect, a preparation method and application. Background technique [0002] Parkinson's disease (PD) is a central nervous system degenerative disease characterized by progressive death of dopaminergic neurons in the substantia nigra of the midbrain. At present, the main treatment method is western medicine, but it only improves the symptoms, but cannot control its progress, and the curative effect is weakened and the toxicity increases after long-term application. And Chinese medicine treatment has advantages such as little toxic and side effects, strong synergistic effect and more development prospects. [0003] Atractylodes macrophylla Atractylodes macrocephala The dried rhizome of Koidz. has the effects of invigorating the spleen and replenishing qi, drying dampness and diuresis, antiperspirant, and ...

Claims

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Application Information

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IPC IPC(8): A61K36/284A61P25/16
Inventor 窦德强冉小库谭成康廷国
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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