Atractylenolide extract having antiparkinsonian effect, preparation method and application thereof
An atractylodes lactone and anti-Parkinsonian technology, applied in the field of traditional Chinese medicine, can solve the problems of no anti-Parkinsonian effect, easy volatilization, long time, etc. Effect
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Embodiment 1
[0030] This example provides an extract of Atractylodes macrolide with anti-Parkinson effect. The extract contains Atractylodes atractylodes I in a weight percentage of 7.5%, Atractylodes atractylodes II in a weight percentage of 12.3% and Atractylodes atractylodes The weight percent of ester III is 25.7%, and the purity of total lactones is 45.5% by weight.
[0031] This embodiment also provides a preparation method of Atractylodes lactone extract with anti-Parkinson effect, including the following steps.
[0032] Step 1. Take 50 g of Atractylodes macrocephala medicinal material, pulverize it, and pass through a 10-mesh sieve to obtain Atractylodes macrocephala powder.
[0033] Step 2. Use hydrogen peroxide to oxidize atractylone in Atractylodes macrocephala powder: use 50 mL of hydrogen peroxide with a volume percentage of 20%, infiltrate for 4 hours, and oxidize at 50° C. for 8 hours.
[0034] Step 3. After the oxidation of the Atractylodes macrocephala powder is completed...
Embodiment 2
[0087] This example provides an extract of Atractylodes macrolide with anti-Parkinson effect. The extract contains Atractylodes atractylodes I at a weight percentage of 8.3%, Atractylolide II at a weight percentage of 14.2% and Atractylodes atractylodes The weight percent of ester III is 27.2%, and the purity of total lactones is 49.7% by weight.
[0088] This embodiment also provides a preparation method of Atractylodes lactone extract with anti-Parkinson effect, including the following steps.
[0089] Step 1. Take 50 g of Atractylodes macrocephala medicinal material, pulverize it, and pass through a 20-mesh sieve to obtain Atractylodes macrocephala powder.
[0090] Step 2. Use hydrogen peroxide to oxidize atractylone in Atractylodes macrocephala powder: use 50 mL of hydrogen peroxide with a volume percentage of 30%, infiltrate for 3 hours, and oxidize at 40° C. for 6 hours.
[0091] Step 3. After the oxidation of the Atractylodes macrocephala powder is completed, it is drie...
Embodiment 3
[0096] This example provides an extract of Atractylodes macrolide with anti-Parkinson effect. The extract contains Atractylodes atractylodes I in a weight percentage of 8.7%, Atractylodes atractylodes II in a weight percentage of 11.1% and Atractylodes atractylodes The weight percent of ester III is 28.7%, and the purity of total lactones is 48.5% by weight.
[0097] This embodiment also provides a preparation method of Atractylodes lactone extract with anti-Parkinson effect, including the following steps.
[0098] Step 1. Take 50 g of Atractylodes macrocephala medicinal material, pulverize it, and pass through a 20-mesh sieve to obtain Atractylodes macrocephala powder.
[0099] Step 2. Oxidation of atractylone in Atractylodes macrocephala powder with hydrogen peroxide: use 100 mL of hydrogen peroxide with a volume percentage of 30%, infiltrate for 6 hours, and oxidize at 50° C. for 4 hours.
[0100] Step 3. After the oxidation of the Atractylodes macrocephala powder is compl...
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