FHA/beta-TCP/beta-Ca2P2O7 three-phase ceramic preparation method

A technology for preparation of -ca2p2o7, ceramics, applied in the field of biomedical materials, can solve the problem that the harmful biological effects of alumina nanoparticles cannot be completely removed

Inactive Publication Date: 2016-01-27
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this technology cannot completely remove the harmful biological effects of alumina nanoparticles, so as to obtain bioceramics with biological characteristics closer to those of fluorinated hydroxyapatite

Method used

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  • FHA/beta-TCP/beta-Ca2P2O7 three-phase ceramic preparation method
  • FHA/beta-TCP/beta-Ca2P2O7 three-phase ceramic preparation method
  • FHA/beta-TCP/beta-Ca2P2O7 three-phase ceramic preparation method

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Experimental program
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Embodiment 2

[0024] This embodiment includes the following operations: 0.04mol calcium acetate monohydrate is dissolved in 200mL water, 0.024mol potassium dihydrogen phosphate and 1.6×10 -3 mol potassium fluoride dihydrate was dissolved in 120mL water, the potassium hydroxide solution was used to adjust the pH of the two solutions to 7, and then the KH 2 PO 4 The mixed solution with KF was added dropwise to Ca(CH 3 COO) 2 solution, while closing the reaction vessel to avoid CO 2 Reacted. The pH of the solution was adjusted to be 7 every 1h, electromagnetically stirred for 4h, aged for 24h, and dried at 80°C to obtain the following: image 3 The precursor powder shown in a.

[0025] The precursor powder was sintered at 600°C, the holding time was 2h, and the heating rate from room temperature to 600°C was 10°C / min.

[0026] This embodiment obtains FHA / β-TCP / β-Ca 2 P 2 o 7 Three-phase ceramics, the structure is dispersed and the composition is uniform, such as image 3 As shown in ...

Embodiment 3

[0028] This embodiment includes the following operations: 0.04mol calcium acetate monohydrate is dissolved in 200mL water, 0.024mol potassium dihydrogen phosphate and 3.2×10 -3 mol potassium fluoride dihydrate was dissolved in 120mL water, the potassium hydroxide solution was used to adjust the pH of the two solutions to 7, and then the KH 2 PO 4 The mixed solution with KF was added dropwise to Ca(CH 3 COO) 2 solution, while sealing the reaction vessel to avoid CO 2 Reacted. The pH of the solution was adjusted to 7 every 1 hour, electromagnetically stirred for 4 hours, aged for 24 hours, and then dried at 80° C. to obtain a precursor powder.

[0029] The precursor powder is sintered at 1000°C, the holding time is 2h, and the heating rate from room temperature to 1000°C is 10°C / min.

[0030] This embodiment obtains FHA / β-TCP / β-Ca 2 P 2 o 7 The three-phase ceramic has better biodegradability and higher thermal stability than that of Example 2.

Embodiment 4

[0032] This embodiment includes the following operations: 0.04mol calcium acetate monohydrate is dissolved in 200mL water, 0.024mol potassium dihydrogen phosphate and 4.8×10 -3 mol potassium fluoride dihydrate was dissolved in 120mL water, the potassium hydroxide solution was used to adjust the pH of the two solutions to 7, and then the KH 2 PO 4 The mixed solution with KF was added dropwise to Ca(CH 3 COO)2 solution, while sealing the reaction vessel to avoid CO 2 Reacted. The pH of the solution was adjusted to 7 every 1 hour, electromagnetically stirred for 4 hours, aged for 24 hours, and then dried at 80° C. to obtain a precursor powder.

[0033] The precursor powder is sintered at 1100°C, the holding time is 2h, and the heating rate from room temperature to 1100°C is 10°C / min.

[0034] This embodiment obtains FHA / β-TCP / β-Ca 2 P 2 o 7 Three-phase ceramics, the three-phase structure coexists and is mixed evenly, such as image 3 As shown in c, the sintering stability...

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Abstract

The invention provides an FHA/beta-TCP/beta-Ca2P2O7 three-phase ceramic preparation method in the field of biomedical material preparation. FHA/beta-TCP/beta-Ca2P2O7 three-phase ceramic is obtained by preparing precursor powder through a chemical precipitation method with calcium acetate monohydrate, monopotassium phosphate and potassium fluoride dehydrate as raw materials and sintering the precursor powder at a high temperature for 2 h. The process is simple, and the obtained three-phase ceramic is uniform in component and has high osteoconduction, biodegradability and mechanical strength, and is an ideal biochemical medical material.

Description

technical field [0001] The present invention relates to a technology in the field of biomedical materials, specifically a FHA / β-TCP / β-Ca 2 P 2 o 7 Three-phase ceramic preparation method. Background technique [0002] Fluorinated hydroxyapatite (FHA) is formed by replacing OH- with F- in hydroxyapatite (HA) crystals. FHA with an appropriate amount of fluorine has stronger chemical stability than HA and is osteoinductive. FHA ceramics have high strength, but poor degradability, while β-tricalcium phosphate (β-TCP) has good biodegradability. After degradation in the body, it can increase abundant calcium and phosphorus elements for bone growth and promote new bone formation. Make up for the lack of FHA. β-calcium pyrophosphate (β-Ca 2 P 2 o 7 ) ceramics can be osseointegrated with bone tissue in vivo, and will not form fiber wrapping at the interface between the two. The bonding strength at the interface increases with time, has good biological activity, and the degradat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447
Inventor 饶群力郭晓亮
Owner SHANGHAI JIAO TONG UNIV
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