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Modified sodium alginate and application thereof

A modification technology of sodium alginate, which is applied in the direction of organic active ingredients, medical preparations containing active ingredients, blood diseases, etc., can solve the problems of non-degradability, high swelling rate of hydrogel, poor biocompatibility, etc., and achieve Good biocompatibility and biodegradability, low price effect

Active Publication Date: 2016-01-27
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its advantage is that it has a strong hemostatic ability, but its disadvantage is that it has poor biocompatibility and cannot be degraded
[0006] Although the existing sodium alginate encounters calcium ions (Ca 2+ ) and other divalent cation aqueous solutions will form hydrogels, but the swelling rate of the formed hydrogels in physiological saline is very high
If the existing sodium alginate is used as a hemostatic agent, there are obviously problems

Method used

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  • Modified sodium alginate and application thereof
  • Modified sodium alginate and application thereof
  • Modified sodium alginate and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Weigh 10 g of sodium alginate with a molecular weight of 50 kDa and M / G=1:1, dissolve it in 200 mL of an aqueous solution with pH=3, and prepare a 50 g / L sodium alginate aqueous solution. Dissolve EDC (1g) and NHS (1g) in 5mL of water to prepare a catalyst solution, add the prepared catalyst solution to the above aqueous solution of sodium alginate with a concentration of 50g / L, and stir at room temperature (20°C) for 1 hour, then add L-cysteine ​​methyl ester hydrochloride (2g), heat up to 60°C, continue to stir for 2h, stop stirring, settle with 400mL of ethanol, collect the precipitate by suction filtration, wash the precipitate with 50ml of ethanol respectively Finally, the precipitate was washed three times with 50 mL of ether, and dried in vacuum for 4 hours to obtain thiol-modified sodium alginate (abbreviated as "SA-SH-1"). The mercapto group grafting rate of SA-SH-1 was 10 %.

[0037] Put SA-SH-1 in a ball mill and pulverize it, weigh 0.1g of powdered SA-SH-1 ...

Embodiment 2

[0043] Weigh 10 g of sodium alginate with a molecular weight of 150 kDa and M / G=1:0.5, dissolve it in 200 mL of an aqueous solution with pH=5, and prepare a 15 g / L sodium alginate aqueous solution. Dissolve EDC (2g) and NHS (2g) in 10mL of water to prepare a catalyst solution, add the prepared catalyst solution to the above aqueous sodium alginate solution with a concentration of 15g / L, and stir at room temperature (20°C) for 1 hour, then add L-cysteine ​​methyl ester hydrochloride (4g), heat up to 50°C, continue to stir for 2h, stop stirring, settle with 800mL of ethanol, collect the precipitate by suction filtration, wash the precipitate with 100ml of ethanol respectively Finally, the precipitate was washed five times with 100 mL ether, and dried in vacuum for 12 hours to obtain mercapto-modified sodium alginate (abbreviated as "SA-SH-2"). The mercapto group grafting rate of SA-SH-2 15%.

[0044]Put SA-SH-2 in a ball mill and pulverize it, weigh 0.1g of powdered SA-SH-2 int...

Embodiment 3

[0047] Weigh 10 g of sodium alginate with a molecular weight of 300 kDa and M / G=1:1, dissolve it in 200 mL of an aqueous solution with pH=6, and prepare a 50 g / L sodium alginate aqueous solution. Dissolve EDC (3g) and NHS (3g) in 20mL of water to prepare a catalyst solution, add the prepared catalyst solution to the above aqueous sodium alginate solution with a concentration of 15g / L, and stir at room temperature (20°C) for 3 After 1 hour, add L-cysteine ​​methyl ester hydrochloride (5g), heat up to 40°C, continue to stir for 24h, stop stirring, settle with 1L of ethanol, collect the precipitate by suction filtration, wash the precipitate with 200ml of ethanol respectively Finally, the precipitate was washed three times with 200 mL ether, and dried in vacuum for 16 hours to obtain thiol-modified sodium alginate (abbreviated as "SA-SH-3"). The mercapto group grafting rate of SA-SH-3 was 25 %.

[0048] Put SA-SH-3 in a ball mill and pulverize it, weigh 5g of powdered SA-SH-3 an...

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Abstract

The invention relates to modified sodium alginate and application thereof. The modified sodium alginate is obtained by grafting 10%-40% of perssad containing perssad onto existing sodium alginate. The modified sodium alginate has the advantages that the needed time for forming hydrogel is short and within one second to five minutes; good biocompatibility and biodegradability are achieved; swelling in normal saline does not exist. The modified sodium alginate can serve as hemostatic.

Description

technical field [0001] The invention relates to a modified sodium alginate and its application. Background technique [0002] Sodium alginate is a natural marine polysaccharide extracted from marine brown algae. Its structure contains two structural units of α-L-guluronate (G) and β-D-mannuronate (M). The structural formula of sodium alginate is shown in Formula A. At present, sodium alginate is mainly used in the field of biomaterials such as microcapsules, drug sustained release or nanomicelle preparation. [0003] [0004] There are two ways of hemostasis after hemorrhage in the human body: physiological hemostasis and auxiliary hemostasis. Physiological hemostasis refers to relying on platelets, coagulation factors and other substances in the blood to form blood clots at the bleeding site, thereby achieving the purpose of hemostasis; auxiliary hemostasis refers to relying on various forms of hemostatic agents to enhance physiological hemostasis by covering and bond...

Claims

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Application Information

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IPC IPC(8): C08B37/04A61K31/734A61P7/04
Inventor 郎美东许冠哲徐衡
Owner EAST CHINA UNIV OF SCI & TECH
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