Preparation method of cefquinome sulfate breast injectant and obtained preparation
A technology of cefquinome sulfate and breast injection, which is applied in the field of preparation of cefquinome sulfate breast injection, can solve the problem that the cefquinome sulfate breast injection cannot be re-mixed to reach the use state, the cefquinome sulfate breast injection is easy to separate out, and the dosage form is redispersed Unsatisfactory stability and other problems, to achieve the effect of ensuring drug content uniformity, stable content, and good redispersibility
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[0031] During specific implementation, the preparation method of cefquinome sulfate breast injection of the present invention comprises:
[0032] The first step is to divide the predetermined amount of oily solvent into the first solvent and the second solvent according to the volume ratio (1.5-2.5): (5.5-6.5); or, divide the predetermined amount of oily solvent according to the volume ratio (1.5-2.5): (5.5-6.5): (0.5-1.5): (0.5-1.5) is divided into the first, second, third and fourth solvents.
[0033] Specifically, the oily vehicle is selected from one of soybean oil, ethyl oleate, medium chain triglyceride, tea seed oil or a combination thereof. The oily medium should be filtered, sterilized by heat before use, and let it cool for later use.
[0034] In the second step, the first solvent, a predetermined amount of main drug cefquinoxime sulfate, and a predetermined amount of wetting agent are placed in a grinding device for grinding. After grinding, the mixture is white or...
Embodiment 1
[0051] In the cefquinome sulfate breast injection of the present embodiment, every 100ml breast injection consists of the following components:
[0052]
[0053]
[0054] The oily vehicle in this example is prepared by mixing soybean oil and ethyl oleate at a volume ratio of 1:7.
[0055] Preparation method: (1) Take the prescribed amount of ethyl oleate and the prescribed amount of soybean oil, mix the two evenly according to the above volume ratio to form a mixed solvent, filter and sterilize and divide into two parts for later use, namely the first and the second , solvent, their volume ratio is 2:6;
[0056] (2) Take the first solvent, the main drug cefquinome sulfate after jet milling in the prescribed amount, and the wetting agent Span 80 in the prescribed amount, put it in a ball mill and grind it for at least 10 minutes, and it will be an off-white mixture with finer particles and evenly dispersed;
[0057] (3) Take the second solvent, the prescribed amount of s...
Embodiment 2
[0063] In the cefquinome sulfate breast injection of the present embodiment, every 100ml breast injection consists of the following components:
[0064]
[0065] The oily vehicle in this example is prepared by mixing soybean oil and ethyl oleate at a volume ratio of 1:8.
[0066] Preparation method: (1) Take the prescribed amount of ethyl oleate and the prescribed amount of soybean oil, mix the two evenly according to the above volume ratio to form a mixed solvent, filter and sterilize, and divide it into four parts for later use, namely the first and second , The third and fourth solvents, their volume ratio is 1.5:6.5:0.5:1.5;
[0067] (2) Take the first solvent, the prescribed amount of air-pulverized main drug cefquinome sulfate, and the prescribed amount of wetting agent Span 80, put it in a ball mill and grind it for at least 10 minutes, and it will be a white or off-white mixture with fine and dispersed particles. Uniform;
[0068] (3) Take the second solvent, the ...
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Abstract
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