Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Drug for treating oral diseases and preparation method thereof

A technology for drugs and liquid preparations, applied in drug combinations, pharmaceutical formulations, respiratory diseases, etc., can solve the problem of ulcer inhibition efficiency needs to be improved, and achieve the effect of helping cancer treatment, preventing bacterial growth, and improving therapeutic effects

Inactive Publication Date: 2016-02-17
WUXI CHENGBO SCI & TECH DEV
View PDF7 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its inhibitory effect on ulcers needs to be improved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] 20 g of polyvinylpyrrolidone K30 (PVPK30) (BASF) was dissolved in about 400 g of purified water. 28.4 g of concentrated hydrochloric acid was added thereto, and purified water was further added to prepare 550 g of PVPK30-hydrochloric acid aqueous solution. Separately, 8.8 g of sodium hydroxide was added to about 1300 g of purified water to prepare an aqueous sodium hydroxide solution. 40.8 g of rebamipide (Otsuka Pharmaceutical Co., Ltd.) was dissolved in an aqueous sodium hydroxide solution while heating the solution, and then purified water was added thereto to adjust the total weight of the sodium hydroxide-rebamipide solution to 1470 g .

[0055] Cooled in an ice bath, with a disperser ( PRIMIX Corporation) gradually added the above-mentioned sodium hydroxide-rebamipide solution whose temperature was kept at 50-55° C. to the aqueous solution of PVPK30-hydrochloric acid stirred at 3000 rpm to precipitate rebamipide crystals. After the whole sodium hydroxide-rebam...

Embodiment 2

[0074] 10 g of polyvinylpyrrolidone K30 (PVPK30) (BASF) was dissolved in about 400 g of purified water. 28.4 g of concentrated hydrochloric acid was added thereto, and purified water was further added to prepare 550 g of PVPK30-hydrochloric acid aqueous solution. Separately, 8.8 g of sodium hydroxide was added to about 1300 g of purified water to prepare an aqueous sodium hydroxide solution. 40.8 g of rebamipide (Otsuka Pharmaceutical Co., Ltd.) was dissolved in an aqueous sodium hydroxide solution while heating the solution, and then purified water was added thereto to adjust the total weight of the sodium hydroxide-rebamipide solution to 1470 g .

[0075] Cooled in an ice bath, with a disperser ( PRIMIX Corporation) gradually added the above-mentioned sodium hydroxide-rebamipide solution whose temperature was kept at 50-55° C. to the aqueous solution of PVPK30-hydrochloric acid stirred at 3000 rpm to precipitate rebamipide crystals. After the whole sodium hydroxide-rebam...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Viscosity rangeaaaaaaaaaa
Concentrationaaaaaaaaaa
The average particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention relates to drug for treating oral diseases and a preparation method thereof. The drug is a liquid preparation and comprises rebamipide serving as an active ingredient, a dispersant and a viscosity enhancer, a viscosity range of the liquid preparation is 10mPa.s-500mPa.s, concentration of rebamipide is 10mg / mL-50mg / mL, and average grain size of rebamipide is smaller than 500 micrometers, and the viscosity enhancer is a mixture of hydroxy propyl cellulose, polyvinyl alcohol and sodium carboxymethylcellulose. The mixture of hydroxy propyl cellulose, polyvinyl alcohol and sodium carboxymethylcellulose is used as the viscosity enhancer, so that viscosity of the drug can be enhanced better and better treatment effect can be realized.

Description

technical field [0001] The invention relates to a medicament suitable for treating diseases of the oral cavity or pharynx, especially oral mucosal disorders, which contains rebamipide as an active ingredient, and a preparation method of the medicament. Background technique [0002] known rebamipide [chemical name: 2-(4-chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid] or Its salts are used as medicines for gastritis / stomach ulcers. In addition, rebamipide is disclosed to be useful for treating dry eye, ie, xerophthalmia (JP9-301866A), and a pharmaceutical composition containing rebamipide as a salivary secretion stimulating agent is also known (JP2006-528662T). Furthermore, JP8-012578A discloses an oral formulation comprising rebamipide, which has an inhibitory effect on the production of interleukin-8, and the treatment covered therein includes the treatment of stomatitis. [0003] The main methods of treatment for head and neck cancer include surgical re...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K47/38A61K47/32A61K31/4704A61P1/02A61P11/04A61P35/00
Inventor 李飞
Owner WUXI CHENGBO SCI & TECH DEV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com