A kind of preparation method of 1-methylimidazole
A technology of methyl imidazole and methyl group, which is applied in the field of preparation of 1-methyl imidazole, can solve the problems of low yield and the like, and achieve the effects of reducing production cost, being easy to promote in large-scale industrialization, and having a simple preparation method.
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Embodiment 1
[0027] Raw materials and their mole fractions: 1 part of 2-chloro-2-(((methylamino)methyl)imino)ethyl triflate, 3.5 parts of ethanol, 2.5 parts of hydrogen chloride, 0.2 part of glacial acetic acid, 4 parts of sodium hydroxide (existing at a concentration of 2 mol / L in water); wherein, except for aqueous sodium hydroxide solution, all raw materials need to be dehydrated first.
[0028] Preparation:
[0029] (1) Dissolve 2-chloro-2-(((methylamino)methyl)imino)ethyl triflate in ethanol, stir at 4°C for 8 hours and set aside;
[0030] (2) Pass hydrogen chloride gas into the mixed system obtained in step (1), react at 20°C for 5h under airtight conditions, add glacial acetic acid, and stir at 4°C for 2h;
[0031] (3) Add aqueous sodium hydroxide solution to the mixed system obtained in step (2), stir and react at 43° C. for 4 h, extract with chloroform, rotary evaporate, and dry to obtain 1-methylimidazole.
Embodiment 2
[0033] Raw material and preparation method are the same as embodiment 1, difference is, no longer add glacial acetic acid in the step (2).
Embodiment 3
[0035] The raw materials and preparation method are the same as those in Example 1, except that the ethanol in step (2) is an aqueous ethanol solution with a volume fraction of 80%.
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