Multi-term ion biochemical analysis dry plate and preparation method thereof

Abstract

The invention relates to a multi-term ion biochemical analysis dry plate and a preparation method thereof, which belong to the technical field of a blood gas biochemical sensor, and the multi-term ion biochemical analysis dry plate is used for detecting sodion, potassium ions, calcium ions, chloride ions and carbon dioxide concentration in body fluid. The dry plate comprises a supporting layer, a sodion selective electrode, a potassium ions selective electrode, a calcium ions selective electrode, a chlorine ions selective electrode, a carbon dioxide selection electrode, a reference electrode, an interface layer, a salt bridge and a top. The salt bridge is sealed between the interface layer and the top, sodion, potassium ions, calcium ions, chloride ions, the carbon dioxide selection electrode and the reference electrode are respectively bounded to the supporting layer, the interface layer and the top for assembly to obtain the dry plate. When a test is carried out, a reference liquid and a test liquid are mutually conducted through osmosis of the salt bridge. The dry plate can simultaneously measure the sodion, the potassium ions, the calcium ions, the chloride ions and the carbon dioxide concentration in the liquid to-be-measured, has the advantages of simple operation, fast response speed and small volume, has the characteristics of simple preparation operation and low production cost, and is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of blood gas biochemical sensors, in particular to a multi-ion biochemical analysis dry sheet and a preparation method thereof. Background technique [0002] Sodium, potassium, calcium, chloride ions and carbon dioxide in human body fluids participate in many important functions and metabolic activities in the body, and play a very important role in maintaining normal life activities. Disturbances in electrolyte and acid-base balance can cause various organs in the body, especially The physiological functions of the cardiovascular system, the nervous system, and the body's substance metabolism have corresponding obstacles, and even endanger the lives of patients. [0003] At present, traditional ion-selective electrodes are mostly used to detect the concentrations of sodium, potassium, calcium, chloride ions and carbon dioxide in body fluids clinically. The internal reference solution of traditional ion-sel...

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Problems solved by technology

The internal reference solution of traditional ion-selective electrodes generally uses electrolyte solutions, which can only work at lower temperatures and pressures. In addition, traditional ion-selective electrodes can only detect one ion concentration at a time, and cannot quickly analyze and judge the electrolyte disorder and The acid-base balance disorder prolongs the treatment time of patients, and the use and maintenance are complicated, costly, and not easy to carry. It cannot meet the needs of surgery, emergency, field rescue, etc., and cannot adapt to family medicine and modern medical in vitro diagnostic equipment models. the trend of

[0004] Chinese patent CN202189033U discloses a card-type electrolyte test electrode matched with a dry electrolyte analyzer. This patent provides a method for simultaneously measuring the concentration of sodium, potassium, chlorine, calcium and hydrogen ions, but its sodium, potassium, chlorine, Calcium and hydrogen ion electrodes need to be used in pairs, and the structure and preparation process are relatively complicated

[0005] The existing patents basically use screen printing technology to prepare electrodes, but the metal layer produced by screen printing is not pure enough and the surface is uneven, which will affect the stability of the potential and response time; in the existing solid-state ion selective electrodes, all use polychloride Ethylene is used as a non-conductive polymer binder for ion-selective membranes (patents CN101852761A, CN104330449A, CN102636532A, CN101871912A, CN102558724A), polyvinyl chloride has high strength and chemical stability, and is cheap, but it must add plasticizers In order to ensure the response of the ion-selective membrane, as time goes by, the plasticizer and the carrier dissolved in it will leak out of the ion-selective membrane together, resulting in the lower limit of the response of the ion-selective membrane and the shortened life.

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