Integrated spectral probe for raman, reflectance and fluorescence spectral measurements

A technology of Raman spectroscopy and reflectance spectroscopy, applied in Raman/scattering spectroscopy, instruments used for radiological diagnosis, Raman scattering, etc., can solve the problems of pollution, interference spectroscopy, faintness, etc.

Active Publication Date: 2016-02-24
PROVINCIAL HEALTH SERVICES AUTHORITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Naturally, Raman signals are very weak compared to reflection or fluorescence signals
In addition, weak Raman signals may be further hampered by interference from tissue fluorescence as well as spectral contamination caused by background Raman and fluorescence signals and / or spectral signals generated in the optical fiber delivering the illumination light

Method used

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  • Integrated spectral probe for raman, reflectance and fluorescence spectral measurements
  • Integrated spectral probe for raman, reflectance and fluorescence spectral measurements
  • Integrated spectral probe for raman, reflectance and fluorescence spectral measurements

Examples

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Embodiment Construction

[0029] For successful in vivo Raman spectroscopy measurements, the Raman system needs to include a filtering mechanism configured to minimize or eliminate background Raman and fluorescence signals from the fiber material and to be able to collect sufficient signal to This enables Raman spectra to be acquired within seconds or sub-seconds.

[0030] figure 1 An embodiment of a Raman system 10 is schematically shown. The Raman system 10 may include a probe 1 , a light source 2 , a spectrograph 3 and a detector 4 . The light source 2 may be capable of providing an figure 2 )) A monochromatic light source of excitation light that induces Raman scattering, such as a laser. Any other light source or combination of light sources that can provide excitation light to induce Raman scattering in a subject illuminated by the excitation light may be used. The light source 2 may be configured to minimize interference from undesired sources, for example, the light source may be selected ...

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Abstract

Examples of a spectroscopy probe for performing measurements of Raman spectra, reflectance spectra and fluorescence spectra are disclosed. The integrated spectral probe can comprise one or more light sources to provide a white light illumination to generate reflectance spectra, an excitation light to generate an UV / visible fluorescence spectra and a narrow band NIR excitation to induce Raman spectra. The multiple modalities of spectral measurements can be performed within 2 seconds or less. Examples of methods of operating the integrated spectroscopy probe disclosed.

Description

technical field [0001] The present invention generally relates to an integrated spectroscopic probe that facilitates integrated measurements of Raman, reflectance and fluorescence spectra. Background technique [0002] In general, the measurement of reflectance or fluorescence or Raman signals is of great use in biomedical applications, for example for early diagnosis of disease-specific changes at the molecular level. [0003] Reflectance spectroscopy is the analysis of light reflected from tissue. Tissue reflectance spectroscopy can be used to derive information about molecules that strongly absorb light (eg, tissue chromophores). It can also be used to derive information about tissue scatterers, such as the size distribution of nuclei and mean cell density. [0004] Fluorescence spectroscopy is the analysis of fluorescent emissions from tissue. Native tissue fluorophores (molecules that fluoresce when excited by light of the appropriate wavelength) may be sensitive to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01J3/28G01J3/12A61B6/00
CPCG01N21/65A61B5/0071A61B5/0075A61B5/0084A61B5/0086A61B2560/0285G01J3/0213G01J3/0221G01J3/4406G01N21/64G01N21/645G01N2021/6417G01N2021/6484G01N2201/08G01N2201/0833G01N2201/084
Inventor 曾海山苏文豪赵建华
Owner PROVINCIAL HEALTH SERVICES AUTHORITY
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