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Application of Highland Barley Bran Extract in Preparation of α-Glucosidase Activity Inhibitor

A technology of glucosidase and activity inhibitor, which is applied to the application field of highland barley bran extract in the preparation of α-glucosidase activity inhibitor, can solve the problems of low comprehensive utilization rate of highland barley bran and the like, achieves mild conditions, The effect of high activity and easy operation

Active Publication Date: 2018-12-14
BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the emphasis on the highland barley industry and the recognition of the health effects of highland barley, the commercial output of highland barley is gradually increasing, and the amount of by-products in the production and processing of highland barley will also increase rapidly. Highland barley bran is the main processing by-product of highland barley and contains a large amount of active substances , but at present the comprehensive utilization rate of highland barley bran is low, and most of them are used as feed

Method used

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  • Application of Highland Barley Bran Extract in Preparation of α-Glucosidase Activity Inhibitor
  • Application of Highland Barley Bran Extract in Preparation of α-Glucosidase Activity Inhibitor
  • Application of Highland Barley Bran Extract in Preparation of α-Glucosidase Activity Inhibitor

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1, a kind of preparation of highland barley bran extract:

[0036] Use petroleum ether as an organic solvent;

[0037] Grind 1kg of highland barley bran into 50 meshes, sieve, add 5 times the amount (i.e., 5L) of petroleum ether to reflux for extraction for 0.5h, filter, and concentrate the filtrate under reduced pressure to remove the organic solvent to obtain the highland barley bran extract (denoted as E -1) 20.3g.

Embodiment 2

[0038] Embodiment 2, a kind of preparation of highland barley bran extract:

[0039] Crush 1 kg of highland barley bran into 50 meshes, sieve, add 6 times the amount of cyclohexane to reflux and extract 3 times, each time for 1 hour, filter, combine the filtrates and concentrate under reduced pressure to remove the organic solvent (cyclohexane) to obtain highland barley bran Skin extract (E-2) 35.6g.

Embodiment 3

[0040] Embodiment 3, a kind of preparation of highland barley bran extract:

[0041] Crush 1 kg of highland barley bran into 50 meshes, sieve, add 4 times the amount of n-hexane to reflux and extract once, each time for 1.5 hours, filter, and concentrate the filtrate under reduced pressure to remove the organic solvent (n-hexane) to obtain the highland barley bran extract (E-3) 29.2 g.

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Abstract

The invention discloses application of a highland barley bran extract for preparing an alpha-glucosidase activity inhibitor, and particularly relates to a medicine for preparing a medicine, a health care product or a food for preventing and / or treating type-II diabetes. The highland barley bran extract comprises, by mass, 10-60% of total sterol. The total sterol comprises beta-sitosterol, campesterol, fucosterol, stigmasterol and desmosterol.

Description

technical field [0001] The invention relates to the field of deep processing and comprehensive utilization of agricultural by-products; more specifically, it relates to the application of highland barley bran extract in the preparation of α-glucosidase activity inhibitors. Background technique [0002] Diabetes (Diabetes Mellitus, DM) and its complications are a serious threat to human health. The 17th International Diabetes Congress reported that 150 million people have been diagnosed worldwide, and it is predicted that it will increase to 300 million in 2025. In developed countries, the prevalence of DM has reached 3% to 7%, becoming the fourth priority disease after cancer, AIDS and cardiovascular disease, and the fifth leading cause of death in the world. The situation in my country is not optimistic. In 2015, the National Health and Family Planning Commission issued the "Report on the Nutrition and Chronic Diseases of Chinese Residents" and pointed out that the current ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P3/10A23L33/00
CPCA23V2002/00A61K36/899A61K2236/35A61K2236/37A61K2236/39A23V2200/328A23V2250/21
Inventor 龚凌霄王静张慧娟刘英丽孙宝国
Owner BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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