Application of Highland Barley Bran Extract in Preparation of α-Glucosidase Activity Inhibitor

A technology of glucosidase and activity inhibitor, which is applied to the application field of highland barley bran extract in the preparation of α-glucosidase activity inhibitor, can solve the problems of low comprehensive utilization rate of highland barley bran and the like, achieves mild conditions, The effect of high activity and easy operation

A technology of glucosidase and activity inhibitor, which is applied to the application field of highland barley bran extract in the preparation of α-glucosidase activity inhibitor, can solve the problems of low comprehensive utilization rate of highland barley bran and the like, achieves mild conditions, The effect of high activity and easy operation

CN105395927BActive Publication Date: 2018-12-14BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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  • Application of Highland Barley Bran Extract in Preparation of α-Glucosidase Activity Inhibitor
  • Application of Highland Barley Bran Extract in Preparation of α-Glucosidase Activity Inhibitor
  • Application of Highland Barley Bran Extract in Preparation of α-Glucosidase Activity Inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1, a kind of preparation of highland barley bran extract:

[0036] Use petroleum ether as an organic solvent;

[0037] Grind 1kg of highland barley bran into 50 meshes, sieve, add 5 times the amount (i.e., 5L) of petroleum ether to reflux for extraction for 0.5h, filter, and concentrate the filtrate under reduced pressure to remove the organic solvent to obtain the highland barley bran extract (denoted as E -1) 20.3g.

Embodiment 2

[0038] Embodiment 2, a kind of preparation of highland barley bran extract:

[0039] Crush 1 kg of highland barley bran into 50 meshes, sieve, add 6 times the amount of cyclohexane to reflux and extract 3 times, each time for 1 hour, filter, combine the filtrates and concentrate under reduced pressure to remove the organic solvent (cyclohexane) to obtain highland barley bran Skin extract (E-2) 35.6g.

Embodiment 3

[0040] Embodiment 3, a kind of preparation of highland barley bran extract:

[0041] Crush 1 kg of highland barley bran into 50 meshes, sieve, add 4 times the amount of n-hexane to reflux and extract once, each time for 1.5 hours, filter, and concentrate the filtrate under reduced pressure to remove the organic solvent (n-hexane) to obtain the highland barley bran extract (E-3) 29.2 g.

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Abstract

The invention discloses application of a highland barley bran extract for preparing an alpha-glucosidase activity inhibitor, and particularly relates to a medicine for preparing a medicine, a health care product or a food for preventing and / or treating type-II diabetes. The highland barley bran extract comprises, by mass, 10-60% of total sterol. The total sterol comprises beta-sitosterol, campesterol, fucosterol, stigmasterol and desmosterol.

Description

technical field [0001] The invention relates to the field of deep processing and comprehensive utilization of agricultural by-products; more specifically, it relates to the application of highland barley bran extract in the preparation of α-glucosidase activity inhibitors. Background technique [0002] Diabetes (Diabetes Mellitus, DM) and its complications are a serious threat to human health. The 17th International Diabetes Congress reported that 150 million people have been diagnosed worldwide, and it is predicted that it will increase to 300 million in 2025. In developed countries, the prevalence of DM has reached 3% to 7%, becoming the fourth priority disease after cancer, AIDS and cardiovascular disease, and the fifth leading cause of death in the world. The situation in my country is not optimistic. In 2015, the National Health and Family Planning Commission issued the "Report on the Nutrition and Chronic Diseases of Chinese Residents" and pointed out that the current ...

Claims

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Application Information

Patent Timeline
14 Dec 2018
Publication
CN105395927B
IPC
A61K36/899; A61P3/10; A23L33/00
CPC
A23V2002/00; A61K36/899; A61K2236/35; A61K2236/37; A61K2236/39; A23V2200/328; A23V2250/21
Inventors
龚凌霄; 王静