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Traditional Chinese medicine for treating diabetes and nephropathy

A technology for diabetic nephropathy and traditional Chinese medicine, applied in drug combination, urinary system diseases, medical raw materials derived from leeches/helminths, etc., can solve problems such as inability to apply, hyperkalemia, elevated SCr, etc., and achieve the effect of reducing the recurrence rate

Inactive Publication Date: 2016-03-23
QINGDAO HUAREN TECH INCUBATOR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor antagonists (ARB) are the first-line drugs for the treatment of DN, they cannot be used when the serum muscle ratio of patients with renal failure is greater than 265 μmol / L.
Because there are few remaining nephrons at this time, the efferent arteriole must be highly contracted to maintain the "three high" compensatory detoxification in the ball. If ACEI or ARB is given, the efferent arteriole expands and the compensatory mechanism is destroyed, and SCr may occur. Abnormally elevated, may also lead to the occurrence of hyperkalemia

Method used

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  • Traditional Chinese medicine for treating diabetes and nephropathy
  • Traditional Chinese medicine for treating diabetes and nephropathy
  • Traditional Chinese medicine for treating diabetes and nephropathy

Examples

Experimental program
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Effect test

preparation example Construction

[0060] The present invention also provides the preparation method of above-mentioned medicine, it comprises:

[0061] The first step is to take raw astragalus, salvia miltiorrhiza, sealwort, earthworm, leech, scorpion, achyranthes bidentata, sliced ​​turmeric, northern root, tortoise shell, medlar and roasted licorice, and use ethanol percolation according to the above weight ratio. collecting the percolate, purifying, concentrating, drying and pulverizing to obtain the first powder;

[0062] In the second step, the components of the raw material drug are extracted according to the above weight ratio by water extraction, the extract is purified by macroporous adsorption resin, the eluent is concentrated, dried, and pulverized to obtain the second powder;

[0063] In the third step, the first powder and the second powder are mixed, and auxiliary materials and carriers are added to prepare the required dosage form.

[0064] The first step is further specifically taking raw astr...

Embodiment 1

[0068] Embodiment 1 oral liquid 1

[0069]Take 35g of raw astragalus, 25g of salvia miltiorrhiza, 35g of sealwort, 10g of earthworm, 10g of leech, 10g of scorpion, 25g of Achyranthes bidentata, 20g of sliced ​​turmeric, 30g of northern sand ginseng, 25g of tortoise shell, 20g of medlar and 25g of licorice. Powder, mixed together to obtain a mixture, percolation with 1.8kg alcohol concentration of 90% ethanol, after standing for 36 hours, collecting the percolating liquid at a speed of 3ml / min, adjusting the pH to 7, standing for 24 hours, and suction filtration , recovered ethanol and concentrated, dried, crushed to obtain the first powder, 20g of rehmannia glutinosa, 25g of rehmannia glutinosa, 20g of Chuanxiong, 10g of Passepartout, 25g of madder, 30g of turmeric, 25g of Corydalis, 25g of fried yam, 20g of raw Atractylodes macrocephala, 15g of lilies were crushed separately, mixed to obtain the mixture, extracted twice with 900g of water, the extracts were combined, centrifu...

Embodiment 2

[0070] Embodiment 2 oral liquid 2

[0071] Take 35g of raw astragalus, 25g of salvia miltiorrhiza, 35g of sealwort, 10g of earthworm, 10g of leech, 10g of scorpion, 25g of Achyranthes bidentata, 15g of sliced ​​turmeric, 25g of Adenophora chinensis, 25g of tortoise shell, 15g of medlar and 25g of licorice. Powder, mixed together to obtain a mixture, percolation with 1.8kg alcohol concentration of 90% ethanol, after standing for 36 hours, collecting the percolating liquid at a speed of 3ml / min, adjusting the pH to 7, standing for 24 hours, and suction filtration , recovered ethanol and concentrated, dried, crushed to obtain the first powder, 15g of rehmannia glutinosa, 25g of rehmannia glutinosa, 15g of Chuanxiong, 10g of passepartout, 25g of madder, 25g of turmeric, 25g of corydalis, 25g of fried yam, 15g of raw Atractylodes macrocephala, 15g of lilies were crushed separately, mixed to obtain the mixture, extracted twice with 900g of water, the extracts were combined, centrifu...

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Abstract

The invention provides a traditional Chinese medicine for treating diabetes and nephropathy. The traditional Chinese medicine is prepared from astragalus, dried rehmannia roots, prepared rehmannia roots, salviae miltiorrhizae, rhizoma chuanxiong, polygonatum kingianum, earthworms, hirudo, scorpion, rubia cordifolia, curcuma, achyranthes bidentata, radix curcuma, corydalis yanhusuo, yam, atractylodes macrocephala koidz, straight ladybell roots, lily, tortoise shells, turtle shells, fructus lycii and radix liquiritiae. The medicine has effects on tonifying qi, nourishing yin, dispersing blood stasis and dredging collaterals, tonifying qi of middle-jiao energy and strengthening spleens and stomachs, dispersing blood stasis and dredging collaterals, dispersing livers and nourishing blood, nourishing yin fluid and invigorating kidneys and filling marrow. To summarize and review through clinical resources, it is proved through the experiment and research combination that the preparation has a clinical effect on treating diabetes and nephropathy.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine for treating diabetic nephropathy. Background technique [0002] With the development of economy, the improvement of people's living standards and the aging of the population, the disease spectrum of chronic kidney disease is also constantly changing. In modern times, some high incidences caused by unhealthy lifestyles, such as chronic kidney disease caused by diabetes, are increasing day by day. In developed countries, diabetic nephropathy (diabetic nephropathy, DN) has taken the first place in chronic kidney disease (accounting for about 25%-40%). my country is a developing country, and primary glomerulonephritis still ranks first among patients with end-stage renal disease (ESRD), but diabetic nephropathy has been increasing rapidly in recent years. According to statistics, there are about 171 million diabetic patients in th...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P13/12A61P3/10A61K35/646A61K35/62A61K35/586
CPCA61K36/481A61K9/0095A61K35/586A61K35/62A61K35/646A61K36/185A61K36/21A61K36/23A61K36/236A61K36/284A61K36/484A61K36/537A61K36/66A61K36/74A61K36/804A61K36/815A61K36/8945A61K36/8967A61K36/8969A61K36/9066A61K2236/33A61K2236/51A61K2236/55A61K2300/00
Inventor 赵玉妹
Owner QINGDAO HUAREN TECH INCUBATOR
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