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A biocompatible hemostatic product and its preparation method

A technology of biocompatibility and products, applied in the direction of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of inconvenient and other problems, and achieve the effect of preventing blood vessel bleeding

Active Publication Date: 2019-05-31
ENDOCLOT PLUS SUZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of hemostatic glue is only convenient to use on wounds on the body surface, but this type of hemostatic glue cannot be conveniently applied to bleeding wounds in the internal cavity of the human body (for example, the surface of the lining of the digestive tract)
[0013] There is no report of applying PEO powder particles directly to wounds or other affected areas to stop bleeding or seal wounds

Method used

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  • A biocompatible hemostatic product and its preparation method
  • A biocompatible hemostatic product and its preparation method
  • A biocompatible hemostatic product and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1. Biocompatible Hemostatic Articles of PEO Particles

[0055] This example provides a series of biocompatible hemostatic products #1 to #4 containing polyethylene oxide (PEO) particles with different viscosity-average molecular weights, the physicochemical parameters of the PEO particles contained in these biocompatible hemostatic products and the The particle sizes of the biocompatible hemostatic articles are listed in Table 1 below:

[0056] Table 1

[0057]

[0058] The above-mentioned biocompatible hemostatic products #1 to #4 are prepared through the following steps:

[0059] (a) Polyoxyethylene particles with different viscosity-average molecular weights as raw materials are placed in the granulator,

[0060] (b) adding distilled water to the raw material placed in the granulator of step (a);

[0061] (c) Granulating at 40° C. to 50° C., followed by sieving to obtain a biocompatible hemostatic product with a particle size of 50 μm to 250 μm.

[0...

Embodiment 2

[0068] Example 2. Biocompatible hemostatic articles of PEO particles and carboxymethyl starch (CMS)

[0069] This example provides a series of biocompatible hemostatic products #5 to #8 comprising polyoxyethylene (PEO) particles and carboxymethyl starch (CMS) particles in different mass ratios, wherein the viscosity-average molecular weight of the PEO particles is 2,000,000 D. The particle size is 0.5 μm to 2000 μm, and the water absorption rate is 5 to 15; the viscosity average molecular weight of CMS particles is 3,000D to 200,000D, the particle size is 0.5 μm to 1000 μm, and the water absorption rate is 10 to 30. In this embodiment The mass ratio of PEO particles and CMS particles in biocompatible hemostatic products #5 to #8 is listed in Table 2 below, and the control sample used in this embodiment is Arista TM Hemostatic powder (produced by Medafor Inc., USA); molecular weight: 5,000D to 200,000D; particle size: 10 μm to 350 μm, average particle size: 100 μm, water abso...

Embodiment 3

[0079] Example 3. Biocompatible Hemostatic Articles of PEO Particles and Povidone (PVP) Particles

[0080] This example provides a series of biocompatible hemostatic products #9 to #11 comprising polyoxyethylene (PEO) particles and povidone (PVP) particles in different mass ratios, wherein the viscosity-average molecular weight of the PEO particles is 2,000,000D , the particle size is 0.5 μm to 2000 μm, and the water absorption rate is 5 to 15; the viscosity-average molecular weight of PVP particles is 90,000D, the particle size is 0.5 μm to 1000 μm, and the water absorption rate is 5 to 15. The biocompatibility in this embodiment The mass ratios of PEO particles and PVP particles in hemostatic articles #9 to #11 are listed in Table 3 below:

[0081] table 3

[0082] Sample serial number

Mass ratio of PEO particles to PVP particles

#9

6:1

#10

3:1

#11

1:3

[0083] The above-mentioned biocompatible hemostatic products #9 to #11 ar...

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Abstract

The present invention provides a biocompatible hemostatic product and a tissue sealant, which include polyoxyethylene particles, the viscosity-average molecular weight of the polyoxyethylene is 100,000 Daltons to 7,000,000 Daltons, and the polyoxyethylene particles have a The particle size is from 0.5 μm to 2000 μm, and the polyoxyethylene particles have a water absorption ratio of 1 to 500, wherein the hemostatic product forms a gel that can seal bloody wounds after absorbing water; The interstitial fluid exuded wound then forms a gel capable of sealing said interstitial fluid exuded wound. The present invention also provides a method for preparing the biocompatible hemostatic product and tissue sealant, and the application of the biocompatible hemostatic product and tissue sealant on animal body surfaces, tissues and organs, and bloody wounds of tissues or organs in body cavities application in hemostasis, anti-adhesion, anti-infection, promotion of tissue healing and / or closure of wounds.

Description

technical field [0001] The present invention relates to a biocompatible hemostatic product, a tissue sealant and a preparation method thereof. Specifically, the present invention relates to a biocompatible hemostatic product that can be directly applied to human and For damaged wounds of tissues and organs of other mammals, it is a biocompatible hemostatic product and tissue sealant with high water absorption for the purpose of stopping bleeding, sealing wounds, reducing tissue exudation, promoting tissue repair, protecting wound tissue, and preventing infection and its preparation method. Background technique [0002] Surgical operations and trauma usually cause wound bleeding, resulting in a large amount of blood loss, and it is necessary to take timely measures to stop the bleeding. Moreover, the surgeon needs to seal the wound caused by certain reasons according to the operation situation, to prevent further bleeding, and to protect the wound from infection at the same ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/26A61L15/60A61L15/44
CPCA61L15/26A61L15/44A61L2400/04A61L15/46A61L24/0015A61L24/0026A61L24/043A61L24/046A61L26/0076A61P17/02A61L26/0019A61L26/0066A61L2300/418C08L71/02A61L26/0052A61L26/0023A61L26/0014A61L26/009A61L2300/802A61L2300/406A61L2300/41A61K9/14A61L26/0061A61L2300/60
Inventor 纪欣邢程张恒周颖
Owner ENDOCLOT PLUS SUZHOU
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