Preparation method for high-purity glyceryl monolaurate

A high-purity technology of glyceryl laurate, which is applied in the field of preparation of high-purity glycerol monolaurate, can solve the problems of large influence of temperature, easy inactivation of enzymes, high price of lipase, etc., and achieve wide source of raw materials and excellent reaction conditions easy to control effects

Active Publication Date: 2016-03-23
HANGZHOU FUCHUN FOOD ADDITIVE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the synthesis methods of glycerol monolaurate include direct esterification, glycerol hydrolysis, enzyme-directed hydrolysis, etc., wherein glycerol hydrolysis can obtain GML with a content of about 90%, but its industrial production is limited due to the source of raw materials for shrinkage ; Enzyme-directed hydrolysis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] A preparation method of high-purity glyceryl monolaurate, which comprises the following steps and process conditions:

[0015] (1) lauric acid, glycerin, calcium hydroxide are mixed preheating, then above-mentioned lauric acid mixed solution is added in the vacuum reactor and reacted, wherein the weight of lauric acid is 45% of glycerin weight, lauric acid 27kg, glycerin 60kg, Calcium hydroxide 0.522kg, accounting for 0.6% of the total mass of the reactants, keeping the temperature of the vacuum reactor at 220°C, the vacuum degree is -0.09MPa, and the reaction time is 2.5h; after the reaction is completed, the crude ester is obtained, and the crude ester is rapidly cooled After reaching 120°C, filter the supernatant to obtain glyceryl laurate with a purity of 40%;

[0016] (2) Molecular distillation treatment with a purity of 40% glyceryl laurate: first dehydrate and degas it in the first molecular distillation tank, the temperature is 130°C, the vacuum is 200Pa, and th...

Embodiment 2

[0018] A preparation method of high-purity glyceryl monolaurate, which comprises the following steps and process conditions:

[0019] (1) lauric acid, glycerin, calcium hydroxide are mixed and preheated, then above-mentioned lauric acid mixed solution is added in the vacuum reactor to react, wherein the weight of lauric acid is 40% of glycerin weight, lauric acid 24kg, glycerin 60kg, Calcium hydroxide 0.672kg, accounting for 0.8% of the total mass of the reactants, keeping the temperature of the vacuum reactor at 225°C, the vacuum degree is -0.100MPa, and the reaction time is 2.5h; after the reaction is completed, the crude ester is obtained, and the crude ester is rapidly cooled After reaching 130°C, filter the supernatant to obtain glyceryl laurate with a purity of 38%;

[0020] (2) Molecular distillation treatment with a purity of 38% glyceryl laurate: first dehydrate and degas it in the first molecular distillation tank, the temperature is 150°C, the vacuum is 300Pa, and t...

Embodiment 3

[0022] A preparation method of high-purity glyceryl monolaurate, which comprises the following steps and process conditions:

[0023] (1) lauric acid, glycerol, calcium hydroxide are mixed preheating, then above-mentioned lauric acid mixed solution is added in the vacuum reactor and reacted, wherein the weight of lauric acid is 50% of glycerin weight, lauric acid 30kg, glycerin 60kg, Calcium hydroxide 0.54kg, accounting for 0.6% of the total mass of the reactants, keep the temperature of the vacuum reactor at 230°C and the vacuum degree is -0.085MPa, and the reaction time is 2.5h; after the reaction is completed, the crude ester is obtained, and the crude ester is rapidly cooled After reaching 130°C, filter the supernatant to obtain glyceryl laurate with a purity of 42%;

[0024] (2) Molecular distillation treatment with a purity of 42% glyceryl laurate: first dehydrate and degas it in the first molecular distillation tank, the temperature is 140°C, the vacuum is 260Pa, and th...

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Abstract

The invention provides a preparation method for high-purity glyceryl monolaurate. The preparation method comprises the steps of: mixing lauric acid, glycerinum and a catalyst to obtain a mixed liquid; preheating the mixed liquid; then adding the heated mixed liquid into a vacuum reaction for reaction; after reaction, obtaining a coarse ester; quickly cooling the coarse ester to 120-150 DEG C; filtering the coarse ester to obtain the supernatant so as to obtain the glyceryl monolaurate with the purity of 35-45%; and finally, performing four-stage distillation to obtain the glyceryl monolaurate with the purity of 85-95%.

Description

technical field [0001] The invention relates to a preparation method of high-purity glycerol monolaurate, belonging to the technical field of organic synthesis. Background technique [0002] Glycerylmonolaurate (Glycerylmonolaurate, referred to as GML) is a widely used surfactant, with a content of more than 90% of glyceryl monolaurate, which is mainly used in food, cosmetics, preservatives, etc. In addition, GML is neutral to It still has a good antibacterial effect under alkaline conditions, and has been approved by the US Food and Drug Administration (FDA) as a generally recognized safe food additive. At the same time, recently, "Nature" magazine introduced that monolaurin monoglyceride showed a significant effect of inhibiting HIV. [0003] At present, the synthesis methods of glyceryl monolaurate include direct esterification method, glycerol hydrolysis method, enzyme-directed hydrolysis method, etc. Among them, GML with a content of about 90% can be obtained by glycer...

Claims

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Application Information

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IPC IPC(8): C07C67/08C07C67/54C07C69/30
CPCC07C67/08C07C67/54C07C69/30
Inventor 赵灿法王锋晏义锋赵玉东
Owner HANGZHOU FUCHUN FOOD ADDITIVE
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