60results about How to "Large industrial production" patented technology

The invention provides medium-manganese TRIP (Transformation-Induced Plasticity) steel and a preparation method thereof. According to the medium-manganese TRIP steel and the preparation method thereof, medium-manganese cold rolled steel is taken as a raw material; the cost is low; the performance of a final product is realized by adopting critical region heat preserving, quenching cooling and partitioning processes; the structure of the medium-manganese steel is controlled by utilizing an over-aging stage in a continuous annealing production line, and the residual austenite volume fraction of the structure is improved in a relatively short critical annealing time, so that mechanical properties of a product are ensured, and meanwhile, the cost is reduced as much as possible; the performance of the steel is stable, the process fluctuation has little influence on performance, and industrial production is facilitated; and the prepared medium-manganese TRIP steel is high in strength, high in elongation and good in forming property, can be widely applied to reinforcing structural parts, such as a B-pillar reinforcing plate, to improve the collision safety of an overall vehicle, and achieves the effects of reducing weight and reducing emission.

The invention discloses a preparation method for peanut bioactive peptide. The method comprises the following steps: adding peanut protein powder to distilled water, carrying out stirring, followed by standing and microwave treatment to obtain peanut protein powder suspension liquid; adjusting a pH value of the peanut protein powder suspension liquid through a hydrochloric acid solution, then adding compound plant hydrolase Viscozyme L, followed by carrying out the microwave treatment to secondarily carry out enzymolysis to obtain a enzymatic hydrolysate, then killing the enzymes and carryingout cooling to a room temperature; adjusting a pH value of the enzymatic hydrolysate through a sodium hydroxide solution or the hydrochloric acid solution, then adding protease and carrying out the microwave treatment to secondarily carry out the enzymolysis, then killing the protease and carrying out cooling to the room temperature, followed by carrying out centrifugating and freeze drying to obtain the peanut bioactive peptide. The prepared peanut bioactive peptide product provided by the present invention has functional properties of high dissolubility, high emulsibility, strong foamability, good emulsion stability, good foam stability and the like. In addition, the method provided by the present invention is applicable for the industrial production.

The invention discloses an oral prednisone time-selecting release preparation and a preparation method thereof. The oral prednisone time-selecting release preparation provided by the invention mainly consists of 0.3-5 parts of prednisone and derivatives thereof, 10-50 parts of glyceryl behenate and 3-30 parts of hydroxypropyl cellulose, and can further contain a disintegrating agent and other pharmaceutically acceptable excipients. The preparation method is as below: extruding tablet cores or granules containing the drug according to the formula by a tablet press or a dry granulator; and coating the tablet cores or particles containing the drug by a coating pan or a fluidized bed to attach the coating film to the tablet cores or particles containing the drug, so as to obtain the oral prednisone time-selecting release preparation. The oral prednisone time-selecting release preparation provided by the invention can achieve a good balance between the biological rhythm of the patients and the curative effects, and is safer, more convenient and effective compared with a traditional preparation. The oral prednisone time-selecting release preparation is prepared by an extrusion-coating process, which is simple for operation, and the obtained time-selecting release preparation has the advantages of drug stability and high reproducibility.

The invention discloses escherichia coli with coexpression of L-lactate dehydrogenase and formate dehydrogenase. The escherichia coli is characterized in that L-lactate dehydrogenase genes ldhL from bacillus coagulans and formate dehydrogenase genes fdh from candida boidinii are introduced into the escherichia coli, wherein the register number of GenBank of nucleotide sequences of the L-lactate dehydrogenase genes ldhL is KF386111; the register number of GenBank of nucleotide sequences of the formate dehydrogenase genes fdh is AJ011046. The invention further discloses a construction method and an application of the reconstructed escherichia coli. The method has the characteristics of being simple to operate, low in cost, high in product synthesis efficiency and high in optical purity. Thus, an effective way for biosynthesis of L-phenyllactic acid is provided.

The invention discloses a process for separating corydalmine alkaloids by utilizing alkaline silica gel, relating to the field of chemical industry and specifically relating to the process for separating the corydalmine alkaloids by utilizing the alkaline silica gel to perform chromatography. The process is characterized by comprising the following steps of: dissolving a crude extract containing the corydalmine alkaloids by using an appropriate amount of methylene dichloride and/or methanol, mixing with the alkaline silica gel, then performing column chromatography separation by using the alkaline silica gel, performing elusion with one or more of petroleum ether, acetone, methylene dichloride, water and ammonia water, detecting fractions by thin layer chromatography, and merging the fractions containing corydalmine; and recovering the fractions, performing decompression recovery on the solvent, and performing recrystallization to obtain the corydalmine alkaloids with the purity of more than 98%. The process disclosed by the invention has the advantages of no need of using special filler, simplicity in operation, low sample loss, stability and low cost, and can realize the operation from small-quantity preparation in a laboratory to expanded industrial production so as to reduce the production cost.

The invention discloses a monofluoroalkyl-containing compound and its preparation method. The preparation method comprises that in a solvent, in the presence of an alkali, an additive, a ligand and a catalyst, a compound A and a compound B undergo a suzuki coupling reaction to produce a compound C. The catalyst is a nickel salt with a chemical formula of NiLnCl2, NiLnBr2, NiLnI2 or NiQ2. mH2O. The preparation method introduces monofluoroalkyl through a one-step reaction, is efficient and simple, has good function group compatibility and good broad spectrum activity, is free of a highly toxic reagent, has simple and safe aftertreatment processes, is environmentally friendly, utilizes a small amount of a cheap catalyst, allows mild reaction conditions, realizes a high reaction conversion rate, a high yield and a low production cost and is suitable for industrial production.

The invention relates to a preparation method of cholecystokinin octapeptide, in particular to a method for synthesizing the cholecystokinin octapeptide by combining a solid phase method and a liquid phase method. The method mainly solves the technical problem that the existing synthesis method is troublesome in separation of intermediate products, long in preparation period, apt to produce by-products in reaction, high in cost, low in yield and the like. The technical scheme is that the synthesis method comprises the following steps of: (1) synthesizing L-aspartyl-4-tertiary butyl ester-benzene propanamide by using the liquid phase method; (2) synthesizing cholecystokinin octapeptide full-protection fragments by using the solid phase method; (3) carrying out weak acid cutting on the full-protection fragments; (4) carrying out liquid phase condensation on the full-protection fragments and dipeptide fragments to obtain full-protection cholecystokinin octapeptide; (5) cutting, adding the full-protection cholecystokinin octapeptide in cutting fluid for cutting, and then adding ice diethyl ether for sediment to obtain cholecystokinin octapeptide crude products; and (6) purifying the crude products through high-phase liquid chromatogram, preparing, rotatably steaming, carrying out freeze-drying to obtain the cholecystokinin octapeptide competitive products. The method is used for preparing the cholecystokinin octapeptide.

A preparation method of a SnO2-TiO2 composite nano photocatalyst comprises operation steps as follows: (1), mixing tetrabutyl titanate, absolute ethyl alcohol and glacial acetic acid, adding dilute nitric acid to regulate pH, stirring and adding water; (2) adding a SnCl4*5H2O solution into the mixed solution in a molar ratio of titanium to tin to be 3:1, stirring, and aging for 22-26 h; (3) placing the aged material into an autoclave for treatment for 22-25 h at the temperature of 175-185 DEG C, and cooling the material in the autoclave to the room temperature; and (4) performing centrifugal separation on a product, then drying the product at 95-110 DEG C and roasting the product for 2-6 h to obtain a finished product. The SnO2-TiO2 composite nano photocatalyst prepared with the method has higher purity and activity, good dispersibility, high thermostability and good repeatability; the method does not require addition of a surfactant and the like, so that the cost is lower, and the production cost is reduced greatly; and meanwhile, the production time is shortened to 2-3 d, and further, the operation is simple and safe.

The invention provides an amorphous thermal spraying material resistant to high temperature corrosion and wear. The material is mainly composed of molybdenum, chromium and iron relatively low in cost,an alloy is modified by adding trace rare earth elements, the bonding strength is high and at least reaches to 50 MPa, corrosion resistance is superior to that of a traditional high-temperature alloymaterial, and wear resistance is excellent. Compared with other materials, the amorphous thermal spraying material is low in cost, high temperature corrosion resistance and wear resistance are excellent, and the amorphous thermal spraying material can be used as a thermal spraying coating material or wear-resistant surfacing material and is suitable for wide industrial production.

The invention discloses a preparation method of hollow rod-like calcium carbonate. The preparation method comprises the following steps: S1, accurately weighing calcium oxide, dissolving the calcium oxide in water, carrying out heating, stirring and standing digesting, carrying out screening, removing residues, and concentrating the product to obtain raw material calcium hydroxide slurry, S2, transferring the prepared calcium hydroxide slurry into a reaction kettle, adding sodium D-gluconate into the prepared calcium hydroxide slurry according to the concentration molar ratio of the calcium hydroxide slurry, controlling the temperature and the rotating speed of the mixed solution, and introducing CO2 gas for reaction to obtain product slurry, and S3, carrying out suction filtration and washing on the product slurry, separating a solid product, carrying out vacuum drying on the separated solid product, taking out the product and grinding the product into powder to obtain hollow rod-likecalcium carbonate. The method has the advantages of easy control of reaction conditions, high yield, low production cost, novel morphology, narrow particle size range, stable quality, good product dispersibility, simple production equipment, environmental protection, strong operability and the like, is suitable for industrial production, and can be widely popularized and applied.

The invention provides a preparation method of tubeimoside I. The method comprises the following steps of: soaking tubeimu tuber bulbs into an appropriate quantity of organic solvent; extracting by heating, diacolation or by adopting an ultrasonic method; filtering to obtain a tubeimu tuber extracting solution; collecting eluent by adopting one or more processes of polyamide column chromatography, Sephadex LH-20 column chromatography, medium-pressure aluminum oxide column chromatography and the like; recovering a reagent from the eluent at reduced pressure; and cleaning acetone repeatedly to obtain tubeimoside I. The purity of the tubeimoside I prepared with the method is over 90 percent; the method is simple and practical and is suitable for large-scale production.

The invention provides a method for rapidly synthesizing spherical aluminum nitride particles with uniform particle size distribution, and belongs to the technical field of powder preparation. The preparation method comprises the following steps: (1) mixing single-graded alumina powder and an external catalyst with a mass fraction of 0-3% to obtain powder with good uniformity; (2) mixing the powder obtained in step (1) Put the material into a multi-functional sintering furnace, keep it warm for 2-8h under the condition of 1200-1500°C under the mixed gas atmosphere of nitrogen and carbon monoxide, and then cool naturally to obtain aluminum nitride block; (3) ball mill the aluminum nitride block into powder body, treated with acid, washed with water, and finally dried to obtain aluminum nitride powder. The invention has the characteristics of low production cost, simple process, high production efficiency and easy industrial production; the prepared aluminum nitride powder has the advantages of uniform particle size distribution, good particle shape and high purity.

The invention provides a preparation method of a black molybdenum trioxide nanosheet. The preparation method comprises the following steps of: mixing Mo powder and a hydrogen peroxide solution, and carrying out reaction to obtain a MoO3 precursor feed liquid; heating the MoO3 precursor feed liquid for reaction to obtain precipitate, and washing, drying and calcining the precipitate to obtain yellow MoO3 nanosheets; mixing the yellow MoO3 nanosheets with metal powder, performing dispersing in a solution, conducting mixing with concentrated hydrochloric acid, and performing stirring, washing and drying to obtain the black molybdenum trioxide nanosheet. According to the method disclosed by the invention, active metal has strong reducibility at normal temperature and normal pressure in an acidic solution, so that the valence state of Mo<6+> ions in white MoO3 can be induced to be reduced into Mo<5+>, the energy band of MoO3 is narrowed, and the absorbance of MoO3 to sunlight is enhanced. Under the irradiation of natural sunlight, seawater is used as a water source, a black MoO3 film is used as a light absorber, seawater evaporation driven by efficient solar energy can be achieved through photothermal conversion, and the interface temperature can reach 72DEG C at most.

The invention discloses 800 MPa grade cold-rolling dual-phase steel and a manufacturing method thereof. The steel contains the following chemical compositions in percentage by weight: 0.10-0.18% of C, 0.03-0.19% of Si, 2.6-3.0% of Mn, 0.01-0.04% of Als, 0.15-0.9% of Cr, and the balance of Fe and other inevitable impurities. The manufacturing method for the steel comprises the following steps sequentially: heating billet steel to 1150-1250 DEG C along with a furnace and preserving the temperature for 1.5-3 hours under heat insulation condition, then performing hot rolling, wherein the rough rolling start rolling temperature is controlled within the range from 1050 DEG C to 1110 DEG C, the precision rolling finish rolling temperature is controlled within the range from 860 DEG C to 900 DEG C, and the simulation curling temperature is controlled within the range from 560 to 600 DEG C; washing a hot rolled plate with acid and then carrying out cold rolling; wherein the cold rolling pressing rate is controlled to be 45-75%, then performing the annealing treatment, wherein the annealing temperature is controlled within the range from 760 DEG C to 860 DEG C; and slowly cooling the hot rolled plate to 630-680 DEG C after keeping for 1-5 minutes under heat preservation condition and then rapidly cooling to be below 350 DEG C at a speed more than 25 DEG C/s for ageing treatment lasting for 5-10 minutes. The practice proves that the steel has the advantages of low yield strength, low yield ratio, high coefficient of elongation, and excellent forming property, and the manufacturing method has simple process and low cost.

The invention discloses Torulopsis glabrata and a method for fermenting to produce pyruvic acid by adopting a strain. The Torulopsis glabrata is an aspartic acid and lactamine defective pyruvate high yield strain, can reduce the metabolism of the pyruvic acid, and increase the conversion rate of sugar acid. In addition, in the Torulopsis glabrata, a transamination reaction from the pyruvic acid to lactamine exists, and a decarboxylic reaction from aspartic acid to the lactamine also exists. Compared with the prior art, when the strain is adopted to ferment for producing the pyruvic acid, the acid yield can be improved by 38 percent in the same production period, and the conversion rate can be improved by between 2 and 3 percent, so the strain has better prospect of industrialized production.

The invention discloses a tetracyclic terpene compound and a preparation method thereof. The structural formula of the compound is shown as a formula I. The preparation method comprises the following steps of: (1) reacting a compound shown as a formula 2 with an acrylic acid derivative in the presence of a chiral alkali; (2) performing a selective reduction reaction on the obtained product in the presence of a reducing agent and a heptahydrate of cerous chloride, and protecting hydroxyl; (3) performing a reduction reaction on the obtained product; (4) performing Swern oxidation on the obtained product, and performing a Wittig reaction in the presence of hexamethylphosphoric triamide; (5) performing an intra-molecular olefin metathesis reaction on the obtained product under the catalytic action of a Grubbs second generation catalyst to obtain spiro-olefin; and (6) performing a selective cyclopropanation reaction on the spiro-olefin and a diazo compound in the presence of a metal catalyst and a chiral ligand to obtain a compound shown as a formula 1. The method has the advantages of simple steps, mild reaction conditions, high yield, convenience for amplifying, convenience for deriving a product and high industrial production potential.

The invention discloses an irinotecan-cholesterol succinic acid simple lipid ion pair, a liposome and a preparation method and application thereof. The cholesterol succinic acid simple lipid is used as a counter-ionic agent, and the active proton of carboxyl in the cholesterol succinic acid simple lipid structure transfers to the nitrogen of irinotecan amino group, a coordination bond is formed, an ion pair is formed with irinotecan, so that the lipid solubility of irinotecan is improved, and the simple preparation method is easily used for packaging the drug on a phospholipid layer of the liposome, and the drug loading and packaging efficiency are improved. According to the irinotecan-cholesterol succinic acid simple lipid ion pair, the liposome and the preparation method and applicationthereof, the hydrophobic ion pair technology is combined with the nano drug delivery system, the lipid solubility of the insoluble drugs is improved, nano-preparations are developed, the complexity ofthe preparation process is simplified, and the irinotecan-cholesterol succinic acid simple lipid ion pair, the liposome and the preparation method and application thereof is conducive to expanding the industrial production. In addition, irinotecan ion pair and the liposome releases faster in the meta-acid environment, certain pH sensitivity is achieved, good antitumor effect and safety are achieved, and good application is achieved.

The invention discloses a concrete material containing an active additive. The concrete material comprises Portland cement, the active additive, sodium silicate, quartz sand and water, wherein the active additive comprises material A, material B and material C; the material A is made with allophane and potassium carbonate; the material B is made with tartaric acid, maleic acid, ammonium formate, calcium metaaluminate, oxalic acid, sodium tartrate and calcium chloride; the material C is made with sodium silicate, sodium citrate, zinc formate, calcium carbonate, potassium carbonate, sodium acetate trihydrate, calcium formate, calcium metaaluminate and calcium chloride. The problem that traditional concrete material has insufficient overall mechanical strength and anti-permeability performance is solved.

The invention discloses a use of penicillium chrysogenum DXY-1 in the production of p-hydroxyphenylethanol. The invention also discloses a method for producing p-hydroxyphenylethanol, comprising the step of using penicillium chrysogenum DXY-1. The invention adopts the production of p-hydroxyphenylethanol by penicillium chrysogenum for the first time, the process is simple, and the use has great significance for expanding the industrial production of p-hydroxyphenylethanol.

The invention discloses a design and preparation for mannose with high substrate affinity. The invention provides a method for designing and constructing AusMan5AY111F and AusMan5AY115F mutant enzymes with high substrate affinity. Mutation sites are finally determined by sequence homology analysis, homologous modeling, and calculating of binding energy; and the corresponding genes obtained by megaprimer PCR (Polymerase Chain Reaction) are named as Ausman5AY111F and man5AY115F. The invention further discloses a method for constructing, efficiently expressing and purifying mutant enzyme engineering bacteria. The prepared mutant enzymes have the characteristics of high substrate affinity and high catalytic efficiency, large industrial potential productivity and a high economic value.

The invention relates to a high-performance hard-surface surfacing flux-cored wire. The flux-cored wire consists of a sheath and a flux core, and the flux core comprises the following components in percentage by weight of 38-53% of chromium, 11-12% of graphite, 2 to 2.5% of silicon, 1.15 to 1.5% of manganese, 0 to 0.22% of molybdenum, 0.32 to 0.54% of nickel, 12.5 to 14.9% of niobium, 0.42 to 1.07% of of titanium, 0.21 to 0.64% of aluminum, 0.85 to 1.28% of vanadium, 0.42 to 0.64% of titanium, 0.21 to 0.64% of copper, and the balance of iron. A wear-resistant surfacing part manufactured by adopting the high-performance hard-surface surfacing flux-cored wire is high in wear resistance, can keep the hardness of more than or equal to 63 HRC at 350 DEG C according to experiments, is suitable for surfacing treatment of medium-temperature wear, and is simple in production process, low in production cost and suitable for wide industrial production.