Simulation model for evaluating tumor ablation range through ultrasonic mono-modal image fusion

An image fusion, single modality technology, applied in the medical field

Active Publication Date: 2016-03-23
THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far there is no relevant report on the safety boundary mod

Method used

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  • Simulation model for evaluating tumor ablation range through ultrasonic mono-modal image fusion
  • Simulation model for evaluating tumor ablation range through ultrasonic mono-modal image fusion
  • Simulation model for evaluating tumor ablation range through ultrasonic mono-modal image fusion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0125] Embodiment 1 Preparation of Nano Lipid Microbubble Ultrasonic Contrast Agent

[0126] 1. Dissolve the phospholipid components dipalmitoyl phosphatidylcholine, distearoylphosphatidylethanolamine and dipalmitoylphosphatidic acid in chloroform. The mass-number ratio of dipalmitoylphosphatidylcholine, distearoylphosphatidylethanolamine and dipalmitoylphosphatidic acid is 18:1:3.5.

[0127] 2. Add double distilled water containing 10% glycerol (v / v) and 2mg / mL Pluronic F68 after the chloroform volatilizes naturally to form a phospholipid film, and hydrate at 37°C for 1 hour. Acoustic vibration was performed at the liquid-liquid junction for 5 minutes, and octafluoropropane gas was introduced at the same time.

[0128] 3. Centrifuge the microbubble solution at 50×g for 5 minutes, absorb the milky white liquid in the lower layer and transfer it to a tube, centrifuge at 805×g for 30 minutes, discard the lower layer liquid, and resuspend it with PBS to obtain nano-lipid microbu...

Embodiment 2

[0130] Example 2 Preparation of phantom model before ablation

[0131] Weigh 20 g of carrageenan and 1 g of gastric window acoustic contrast agent in a beaker with an electronic balance, and add 1000 mL of double distilled water at 60°C. Place the beaker in a constant temperature water bath at 60°C and stir with a glass rod until the solute is completely dissolved to form normal tissue matrigel. Take 38 mL of Matrigel in a small beaker, add 2 mL of milk to form tumor gel Matrigel, then add nano-lipid microbubble ultrasound contrast agent, stir evenly to form tumor gel. In this example, tumor gel models with nanoscale lipid microbubble ultrasound contrast agent concentrations (calculated by phospholipid mass) of 0.0042%, 0.0056%, 0.007%, 0.0084% and 0.0098% (w / v) were prepared respectively. After placing the tumor glue in a sphere mold with a diameter of 3 cm, place it in ice water and cool it for 5 minutes, and take it out to obtain the tumor glue model.

[0132] The tumor g...

Embodiment 3

[0133] Example 3 Detection of Ultrasonic Imaging Effects of the Phantom Model Before Ablation

[0134] The phantom phantoms with different concentrations of nanoscale contrast agents were examined with contrast-enhanced ultrasound. In this embodiment, Esaote MyLabtwice model clinical ultrasonic diagnostic instrument and linear array probe are used to detect the phantom, the imaging frequency band is 3-11 MHz, the focal point is placed in the middle of the tumor, and the gain is 0.5. For harmonic contrast ultrasound imaging mode, use a mechanical index of 0.03 and a gain of 0.38. 10 min after the phantom model was taken out of the refrigerator was defined as 0 min, and two-dimensional ultrasound and harmonic contrast ultrasound imaging were performed on the phantom model at different time points.

[0135] The result is as figure 2 As shown, at the time point of 0 min, phantom models prepared with different concentrations of nano-scale contrast agents showed different imaging...

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Abstract

The invention belongs to the field of medicine, and relates to a simulation model for evaluating a tumor ablation range through ultrasonic mono-modal image fusion. Tumor glue is embedded in normal tissue glue, so that a pre-ablation model is formed for ablation; and after the ablation, the dissolved tumor glue and some dissolved normal tissue glue around are absorbed out, and ablation glue is poured, so that a post-ablation model is formed which is available for evaluation of the tumor ablation range through ultrasonic mono-modal image fusion. The normal tissue glue includes carrageenan, and the normal tissue glue, under a two-dimensional ultrasonic imaging mode, shows equal echo. The tumor glue, under the two-dimensional ultrasonic imaging mode, shows high echo. The ablation glue includes carrageenan, a special dye and an ultrasonic contrast agent, and the ablation glue, under the two-dimensional ultrasonic imaging mode, shows high echo. When the simulation model is generally observed by naked eyes, the normal tissue glue is represented to be colorless and semitransparent, the tumor glue is white and non-transparent and while the ablation glue is colored and non-transparent, showing strong contrast and facilitating distinguishing. Therefore, by virtue of the simulation model, the tumor ablation range can be accurately evaluated; and the simulation model is suitable for teaching and training of tumor ablation technology.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the fields of contrast-enhanced ultrasound and ultrasound-guided liver cancer diagnosis and interventional therapy in ultrasound medicine, and relates to a teaching and training model for ultrasound single-mode image fusion technology and tumor ablation technology. technical background [0002] Ablation therapy is a minimally invasive, simple and safe treatment method, and has become a commonly used method for treating tumors in clinic. The basic operation is to penetrate a needle-shaped instrument into the tumor tissue, and emit radio frequency or microwave to generate heat through the needle tip, resulting in rapid evaporation of water inside and outside the tumor tissue, protein denaturation and coagulation necrosis of tissue cells. At present, imaging methods are mainly used clinically to judge whether the ablation is complete. Ultrasound has significant advantages in intraoperative ...

Claims

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Application Information

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IPC IPC(8): G09B23/28
CPCG09B23/286
Inventor 郑荣琴许尔蛟李凯周慧超吕淑敏
Owner THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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