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Methosulide sustained-release capsules and preparation method thereof

A technology of sustained-release capsules and sustained-release layers, which is applied in the direction of pharmaceutical formulations, non-central analgesics, antipyretics, etc., can solve the problems of inconvenient taking three times, affect the overall curative effect, and be prone to missed doses, so as to achieve the goal of medication Good compliance, accelerated disintegration and dissolution, and convenient administration

Inactive Publication Date: 2018-11-02
WUHAN OPTICS VALLEY HUMANWELL BIO PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Mesosulide is a poorly soluble drug that can be made into ordinary tablets, but it is not convenient to take it three times a day, and it is prone to missed doses, which affects the overall efficacy
[0004] At present, the research on mesosulide preparations still needs to be in-depth

Method used

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  • Methosulide sustained-release capsules and preparation method thereof
  • Methosulide sustained-release capsules and preparation method thereof
  • Methosulide sustained-release capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] (1) Preparation of Mesosulide-loaded Pill Core

[0070] prescription:

[0071] Prescription Composition of Drug-loaded Pill Core

parts by weight

Mesosulide

100

Crospovidone

10

microcrystalline cellulose

100

Hypromellose

50

[0072] Preparation:

[0073] Superfinely pulverize (i.e. micronize) the raw material of mesosulide with the remaining excipients in the above prescription quantity and mix uniformly, and use 4% hydroxypropyl methylcellulose purified aqueous solution as a binder to mix the above well The powder is made into a soft material, and the drug-loaded pellet core is made by extrusion and spheronization. The extruder adopts single-screw radial screen extrusion, the sieve plate aperture is 0.8mm, and the screw speed is 40r / min. The extrudate is rolled into a mesosulide-loaded pellet core in a centrifugal granulator at a rotational speed of 500 r / min, and the prepared drug-loaded pellet core is dried ...

Embodiment 2

[0092] (1) Preparation of Mesosulide-loaded Pill Core

[0093] prescription:

[0094] Prescription Composition of Drug-loaded Pill Core

parts by weight

Mesosulide

50

Croscarmellose Sodium

15

starch

145

Hypromellose

50

[0095] Preparation:

[0096]Superfinely pulverize the raw material of mesosulide and mix it uniformly with the rest of the excipients in the above prescription quantity, and use 4% hydroxypropyl methylcellulose purified aqueous solution as a binder to make the above mixed powder into a soft material , the method of extruding and spheronizing is used to make the drug-loaded pellet core. The extruder adopts single-screw radial screen extrusion, the sieve plate aperture is 0.8mm, and the screw speed is 40r / min. The extrudate is rolled into a mesosulide-loaded pellet core in a centrifugal granulator at a rotational speed of 500 r / min, and the prepared drug-loaded pellet core is dried at 40°C to obtain the...

Embodiment 3

[0112] (1) Preparation of Mesosulide-loaded Pill Core

[0113] prescription:

[0114] Prescription Composition of Drug-loaded Pill Core

parts by weight

Mesosulide

50

Low-substituted hydroxypropyl cellulose

20

lactose

140

Hypromellose

30

[0115] Preparation:

[0116] Superfinely pulverize the raw material of mesosulide and mix it uniformly with the rest of the excipients in the above prescription quantity, and use 4% hydroxypropyl methylcellulose purified aqueous solution as a binder to make the above mixed powder into a soft material , the method of extruding and spheronizing is used to make the drug-loaded pellet core. The extruder adopts single-screw radial screen extrusion, the sieve plate aperture is 0.8mm, and the screw speed is 40r / min. The extrudate is rolled into a mesosulide-loaded pellet core in a centrifugal granulator at a rotational speed of 500 r / min, and the prepared drug-loaded pellet core is dried a...

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Abstract

The invention provides a Meisuoshuli slow release capsule and a preparation method thereof. The Meisuoshuli slow release capsule comprises a slow release pellet, a hollow capsule is filled with the slow release pellet, the slow release pellet comprises a drug-loaded pellet core and a dressing layer, and the drug-loaded pellet core comprises Meisuoshuli and pharmaceutically acceptable auxiliary materials. The Meisuoshuli slow release capsule has the advantages of stable quality, high bioavailability, good medication compliance, stable blood concentration, high safety, convenient administration, 1-2 time administration every day, slow drug release, effective avoiding of fluctuation of the effective blood concentration due to large fluctuation of the blood concentration, and small toxic and side effects.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to methosulide sustained-release capsules and a preparation method thereof. Background technique [0002] Mesosulide raw materials and preparations are the world's first 1.1 chemical drugs jointly developed by the Academy of Military Medical Sciences and Humanwell Pharmaceutical Group. Mesosulide is a non-steroidal anti-inflammatory drug (NSAID for short), and its main mechanism of action is to inhibit Cyclooxygenase (COX-2) activity, thereby inhibiting the final generation of prostacyclin (PGⅡ), prostaglandin (PGE1, PGE2) and thromboxane A2 (TXA2) from arachidonic acid, that is, reducing prostaglandin, thromboxane and other inflammatory Synthesis of sex media, so it has good antipyretic, analgesic, anti-inflammatory, detumescence and other effects. [0003] Mesosulide is a poorly soluble drug that can be made into ordinary tablets, but it is inconvenient to take three times a day...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K31/18A61P29/00
Inventor 许勇王学海李莉娥廖娟娟黄怡黄璐涂荣华杨仲文乐洋江曦朱垒余艳平刘荃王伟田华肖强范昭泽杨菁张毅
Owner WUHAN OPTICS VALLEY HUMANWELL BIO PHARMA
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