Preparation method of arecoline
A technology of arecoline and organic bases, applied in the direction of organic chemistry, can solve the problems of expensive methyl iodide, high processing costs, long process routes, etc.
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[0032] Add 50g (0.406mol) of nicotinic acid and 45.2g (0.447mol) of triethylamine into 500ml of toluene, raise the temperature to 70°C, add 112.6g (0.894mol) of dimethyl sulfate dropwise at this temperature, after the addition is complete, raise the temperature to 100 °C, react for 3Hr, and cool to room temperature. Since the hydroboration reaction is carried out in a mixed solution of benzene and water (document J.Org.chem.1955, 1761-1766), the reactant in the previous step does not need to be processed to obtain pure N-methyl nicotinic acid methyl ester or N- Methyl nicotinate monomethyl sulfate can be hydroborated. Add 500ml of water to the system formed after the above reaction, and add 31g of NaBH at 35-38°C 4 (0.82mol), added in batches for about 1 hr, and reacted at room temperature for 4 hours after the addition. The whole reaction process is shown in formula VI:
[0033]
[0034] (Formula VI).
[0035] Then stand for stratification, the organic phase is the tol...
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