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A preparation method of titanium metal with antibacterial and anticancer properties

A technology with high performance of titanium metal, applied in the field of preparation of titanium metal, can solve the problems of patient danger, solvent residue, poor water solubility, etc., and achieve the effect of good anticancer ability, low cost, and good antibacterial ability

Active Publication Date: 2018-04-03
东营市大学科技园发展有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the water solubility of curcumin derivatives is poor. If curcumin derivatives are directly introduced to the surface of titanium metal, more organic solvents need to be used, which will pollute the environment, and there may be solvent residues on the titanium metal, which will cause danger to patients.

Method used

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  • A preparation method of titanium metal with antibacterial and anticancer properties
  • A preparation method of titanium metal with antibacterial and anticancer properties
  • A preparation method of titanium metal with antibacterial and anticancer properties

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] This scheme prepares the method for the titanium metal with antibacterial and anticancer performance, comprises the following steps:

[0025] 1) Dissolve 0.5 parts by weight of cyclodextrin in 4 parts by weight of water, stir evenly, add 1 part by weight of titanium metal, and soak for 30 minutes;

[0026] 2) add 1 weight part of curcumin derivatives, then use 20kHz ultrasonic wave for 30min;

[0027] 3) The titanium metal is taken out and dried to obtain the titanium metal with antibacterial and anticancer properties.

Embodiment 2

[0029] This scheme prepares the method for the titanium metal with antibacterial and anticancer performance, comprises the following steps:

[0030] 1) Dissolve 0.6 parts by weight of mono-(6-mercapto)-β-cyclodextrin in 20 parts by weight of water at 50°C, stir evenly, add 1.5 parts by weight of titanium metal, and soak for 60 minutes;

[0031] 2) Add 1.2 parts by weight of curcumin derivatives, then centrifuge at 5000rpm for 10min, and then use 30kHz ultrasonic wave for 60min;

[0032] 3) Take out the titanium metal and dry it with infrared rays.

Embodiment 3

[0034] This scheme prepares the method for the titanium metal with antibacterial and anticancer performance, comprises the following steps:

[0035] 1) Dissolve 1 part by weight of p-hydroxybenzaldehyde in 2 parts by weight of ethyl acetate, add 1 part by weight of benzyl chloride, control the temperature at 70°C, and stir for 2 hours to obtain p-benzyloxybenzaldehyde having the formula (1);

[0036]

[0037] 2) Dissolve 1 part by weight of p-benzyloxybenzaldehyde and 1 part by weight of tributyl borate in 2 parts by weight of ethyl acetate, stir for 4 minutes at room temperature, and then add a mixture of 0.2 parts by weight of acetylacetone and 0.1 part by weight of boron oxide. solution, continue to stir at room temperature for 20 minutes, add 0.2 parts by weight of n-butylamine, continue to stir for 2 hours, stop stirring and let stand for 12 hours, then add 5 parts by weight of hydrochloric acid with a concentration of 0.4mol / L, control 50 ° C, stir for 0.5 hours, and s...

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Abstract

The invention discloses a preparing method for titanium metal with the antimicrobial and anticancer performance. The method includes the following steps that 1, by weight, 0.1-0.6 part of cyclodextrin is dissolved in 3.5-20 parts of water and evenly stirred, and then 0.5-1.5 parts of titanium metal is added and soaked for 20-60 min; 2, by weight, 0.2-1.2 parts of a curcumin derivative is added, and then the mixture is treated for 30-60 min with 15-30 kHz ultrasonic waves; 3, the titanium metal is taken out and dried. According to the method, due to the effects of the cyclodextrin and the curcumin derivative on the titanium metal, the titanium metal has the good antimicrobial and anticancer performance, the surface of the titanium metal is beneficial to growth of osteocytes, the incidence rate of complications caused by the titanium metal in an osseointegration operation is reduced, and a safer and more reliable material is provided for the osseointegration operation.

Description

technical field [0001] The invention relates to the technical field of titanium metal in osseointegration surgery, more specifically to a preparation method of titanium metal with antibacterial and anticancer properties. Background technique [0002] β-cyclodextrin is a class of macrocyclic compounds formed by connecting 7 D-glucopyranose units end-to-end through α-1,4 glycosidic bonds. Inside the molecule is a "V"-shaped hydrophobic cavity, showing a unique molecular recognition ability. As a commonly used material in osseointegration surgery, titanium metal is widely used clinically. However, a serious problem is the associated bacterial infection problem, which leads to the failure of a large number of transplant operations. At present, there have been some reports on improving the antibacterial ability of titanium metal, such as using antibacterial molecules such as antibiotics to improve the antibacterial effect of titanium metal. Recently, researchers have been work...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/06A61L27/54C23C22/68
CPCA61L27/06A61L27/54A61L2300/216A61L2300/404A61L2300/416A61L2300/802A61L2400/18A61L2430/02A61L2430/12C23C22/68
Inventor 李培源苏炜霍丽妮陈睿
Owner 东营市大学科技园发展有限责任公司
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