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Huangyangning dispersible tablets and preparation method thereof

A technology of dispersible tablets and Buyangning, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc.

Active Publication Date: 2016-04-13
INCREASE PHARMA YINGKOU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The key machine parameters are: pre-expansion pressure, pre-expansion temperature and nozzle diameter. These three parameters all play a crucial role in the particle size of the produced micronized raw materials. Research on supercritical fluid granulation

Method used

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  • Huangyangning dispersible tablets and preparation method thereof
  • Huangyangning dispersible tablets and preparation method thereof
  • Huangyangning dispersible tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0135] 1) Use a supercritical reaction device to micronize Cyclovitamin D, wherein the machine parameters are: pre-expansion pressure 25MPA, pre-expansion temperature 320K, nozzle diameter 0.1mm, and obtain micronized Cyclovitamin D;

[0136] 2) Put 2g of micronized cyclovirbuxine D and 3.7g of soybean lecithin in a conical flask, use 200ml of ethanol as the reaction solvent, heat and stir to 55°C, and the rotation speed is 500r / min, react for 1h, take the reaction solution in The reaction solvent was removed by rotary evaporation at 60°C, and the solid was vacuum-dried for 1 hour to obtain the phospholipid complex;

[0137] 3) Mix the phospholipid complex and PEG4000 according to the ratio of 1:2.5, after fully grinding evenly, spray a small amount of absolute ethanol, continue to grind into a uniform thick paste, dry in vacuum at 60°C for 3h, transfer to -20°C for curing for 24h , quickly pulverized after taking out, and passed through an 80-mesh sieve to obtain a phospholip...

Embodiment 2

[0140] 1) Use a supercritical reaction device to micronize Cycloviral Buxillus D, wherein the machine parameters are: pre-expansion pressure 25MPA, pre-expansion temperature 370K, nozzle diameter 0.2mm, and obtain micronized Cycloviral Buxus D;

[0141] 2) Put 2g of micronized cyclovirbuxine D and 3.7g of soybean lecithin in a conical flask, use 200ml of ethanol as the reaction solvent, heat and stir to 55°C, and the rotation speed is 500r / min, react for 1h, take the reaction solution in The reaction solvent was removed by rotary evaporation at 60°C, and the solid was vacuum-dried for 1 hour to obtain the phospholipid complex;

[0142] 3) Mix the phospholipid complex and PEG4000 at a ratio of 1:2, grind them evenly, spray a small amount of absolute ethanol, continue to grind into a uniform thick paste, dry in vacuum at 60°C for 3 hours, transfer to -20°C and solidify for 24 hours , quickly pulverized after taking out, and passed through an 80-mesh sieve to obtain a phospholipi...

Embodiment 3

[0145] 1) Use a supercritical reaction device to micronize Cyclovitamin D, wherein the machine parameters are: pre-expansion pressure 35MPA, pre-expansion temperature 420K, nozzle diameter 0.5mm, and obtain micronized Cyclovitamin D;

[0146] 2) Put 2g of micronized cyclovirbuxine D and 3.7g of soybean lecithin in a conical flask, use 200ml of ethanol as the reaction solvent, heat and stir to 55°C, and the rotation speed is 500r / min, react for 1h, take the reaction solution in The reaction solvent was removed by rotary evaporation at 60°C, and the solid was vacuum-dried for 1 hour to obtain the phospholipid complex;

[0147] 3) Mix the phospholipid complex and PEG4000 at a ratio of 1:3. After fully grinding evenly, spray a small amount of absolute ethanol and continue grinding to form a uniform thick paste. Vacuum dry at 60°C for 3h, transfer to -20°C and solidify for 24h , quickly pulverized after taking out, and passed through an 80-mesh sieve to obtain a phospholipid comple...

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Abstract

The invention discloses Huangyangning dispersible tablets and a preparation method thereof. Raw materials are subjected to nanocrystallization with a supercritical fluid method, then Cyclovirobuxine D, soybean lecithin, PEG4000, microcrystalline cellulose, hydroxypropyl cellulose, aerosil and aspartame are granulated with an equivalent incremental method by use of 60% ethyl alcohol, and drying and tableting are performed. Compared with Huangyangning on the market, the dispersible tablets have characteristics of high solubility and dissolution rate, quick absorption, high bioavailability and the like; the quality of the dispersible tablets can be better improved and development of drugs is facilitated.

Description

technical field [0001] The invention belongs to a huangyangning dispersible tablet and a preparation method thereof, and belongs to the field of pharmaceutical preparations. Background technique [0002] Buyangning Dispersible Tablets are processed from Cycloviral Buxus D as the active ingredient and excipients. [0003] Extracted and refined from poplar plant Euonymus microphylla and its genus, molecular formula C26H46N2O, molecular weight: 402.66, structural formula as follows: [0004] [0005] The currently commercially available Buxusine dispersible tablets mainly use cyclovirboxic star D with a larger particle size, microcrystalline cellulose, pregelatinized starch and other auxiliary materials for conventional granulation and tabletting. The existing disadvantages mainly include: [0006] (1) The particle size of Cyclovitamin D used is relatively large, the uniformity of granulation is poor, the solubility and solubility are poor, and the bioavailability will be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/57A61K47/24A61K47/38A61P9/00A61P9/10A61K36/185
CPCA61K9/2013A61K9/2054A61K31/57A61K36/185
Inventor 高静郑宁李颖
Owner INCREASE PHARMA YINGKOU CO LTD
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