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Medicament for treating herpes simplex keratitis

A technology for viral keratitis and herpes simplex, applied in the direction of antiviral agent, drug combination, drug delivery, etc., can solve the problems of difficult to control recurrence, drug resistance and drug resistance, unsatisfactory curative effect, etc., to improve treatment efficiency , reducing the amount of use, the effect of difficult to relapse

Inactive Publication Date: 2016-04-13
许梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the fact that the current treatment of this disease is still based on local and systemic use of acyclovir (acyclovir, ACV) antiviral, but its effect on corneal repair, healing and regeneration is not good.
Therefore, it is difficult to control the immune inflammatory response caused by viral antigens and the characteristics of recurrent attacks with anti-HSK drugs alone.
Western medicine treatment is prone to drug resistance and drug resistance due to long-term repeated medication, and at the same time it is difficult to control its recurrence, and the curative effect is often unsatisfactory

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0053] The preparation method of the decoction of the oral dosage form is specifically:

[0054] Mix the raw materials according to the above weight to obtain a mixture, add 6 to 8 times the amount of water relative to the mixture, boil for 4 to 6 hours, filter, add 1 to 2 times the amount of water to the filter residue, and boil for 2 to 4 hours. hours, filtered, combined filtrates, and concentrated under reduced pressure to obtain decoction.

[0055] The preparation method of the external dosage form eye drops is specifically:

[0056] The first step is to put Scrophulariaceae, Budisma, Fangfeng, Dogwood, Phellodendron, Radix Isatidis, Blue Buzheng, Millae Spatholobus, Gardenia, Nansha Ginseng, Ligustrum lucidum, Cuscuta, Mud Hucai, Surgeon Grass, Lengshuihua Put it into the mixer according to the above weight, stir and mix evenly to obtain the mixture, put the mixture into the percolation cylinder, add 500g~700g of ethanol with an alcohol concentration of 70%~80% per 100g ...

Embodiment 1

[0060] Example 1 Decoction 1

[0061] Scrophulariaceae 25g, Cuiweizi 30g, Gujingcao 15g, Mimenghua 30g, Fangfeng 25g, Cornus officinalis 35g, Smilax tuckahoe 25g, Phellodendron 60g, Banlangen 35g, Puhuang 35g, Sappan 30g, Lanbuzheng 55g, chicken Mix 30g of sage rattan, 20g of gentian, 25g of gardenia, 35g of Nansha ginseng, 40g of privet fruit, 35g of dodder, 20g of northern wind grass, 15g of mud mustard, 20g of horseshoe grass, 25g of cold water flower and 25g of licorice to obtain a mixture , add relative to 5kg of water, boil for 5 hours, filter, add 1kg of water to the filter residue again, boil for 3 hours, filter, combine the filtrates, and concentrate under reduced pressure to obtain decoction 1.

Embodiment 2

[0062] Embodiment 2 Decoction 2

[0063]Scrophulariaceae 22g, Cuiweizi 27g, Gujingcao 12g, Mimenghua 27g, Fangfeng 22g, Cornus officinalis 32g, Smilax smilax 22g, Phellodendron 57g, Radix Radix 32g, Puhuang 32g, Sappan 27g, Lanbuzheng 52g, chicken Mix 27g of sage rattan, 17g of gentian, 22g of gardenia, 32g of Nansha ginseng, 37g of privet fruit, 32g of dodder, 17g of northern wind grass, 12g of mud mustard, 17g of horseshoe grass, 22g of cold water flower and 22g of licorice to obtain a mixture , add water relative to 4kg, boil for 5 hours, filter, add 1kg of water to the filter residue again, boil for 3 hours, filter, combine the filtrates, concentrate under reduced pressure, and obtain decoction 2.

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PUM

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Abstract

The invention provides a medicament for treating herpes simplex keratitis. The medicament is prepared from the bulk pharmaceuticals of figwort, motherwort fruit, buerger pipewort flower, pale butterflybush flower, divaricate saposhnikovia root, dogwood, glabrous greenbrier rhizome, amur corktree bark, isatis root, cattail pollen, sappan wood, aleppo avens, suberect spatholobus stem, gentian, fructus gardenia, adenophora tetraphylla, glossy privet fruit, south dodder seed, herba leucatis molloissimae, hemistepta lyrata, siberian walking fern, pilea notate and liquoric root. The medicament has a remarkable curative effect. By adopting the medicament, problems in western medicine can be solved, the dosage of the western medicine is reduced, the treatment efficiency is increased, the drug tolerance and drug resistance tending to occur after repeated single use of the western medicine can be avoided, and recurrence after treatment is avoided.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a medicine for treating herpes simplex virus keratitis. Background technique [0002] Viral keratitis is an inflammation caused by infection of the cornea by viral pathogens. Herpes simplex virus keratitis is the most common. , showing typical changes such as dots, dendrites, and maps, which belong to the category of "gathering stars" and "flowers and white depressions" in traditional Chinese medicine. [0003] Herpes simplex virus keratitis is a serious worldwide blinding eye disease caused by herpes simplex virus infection. It is one of the most serious infectious eye diseases in the world. It has great damage to the visual function and brings serious damage to the patient's body and spirit. [0004] Modern medicine believes that recurrent herpes simplex virus keratitis is due to herpes simplex virus keratitis dormant in the cornea and trigeminal ganglion...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/896A61P27/02A61P31/22
CPCA61K36/808A61K9/0048A61K9/0095A61K9/08A61K36/11A61K36/185A61K36/195A61K36/238A61K36/28A61K36/315A61K36/342A61K36/39A61K36/40A61K36/48A61K36/484A61K36/486A61K36/515A61K36/53A61K36/533A61K36/56A61K36/638A61K36/73A61K36/744A61K36/756A61K36/88A61K36/896A61K36/90A61K47/22A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 许梅
Owner 许梅