Preparation method and application of medical composite hydrogel dressing
A composite hydrogel and reaction product technology, applied in medical preparations of non-active ingredients, pharmaceutical formulations, medical science, etc., can solve the problems of poor tensile strength gel strength, inconvenient application, easy to break and break, etc. , to achieve the effects of good gel strength, good medical properties and good tensile properties
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[0031] The raw materials for the preparation of the medical composite hydrogel dressing provided by the present invention include hyaluronic acid, and the hyaluronic acid can make the medical composite hydrogel dressing provided by the present invention have better viscoelasticity, moisture retention, lubricity, and anti-inflammatory properties. and its ability to promote wound healing. The present invention has no special limitation on the source of the hyaluronic acid, and the hyaluronic acid well-known to those skilled in the art can be used, which can be purchased from the market, such as Hylaform series hyaluronic acid provided by Genzyme Corporation of the United States.
[0032] The raw materials for the preparation of the medical composite hydrogel dressing provided by the invention include sodium citrate, which is a natural pH regulator, is easy to obtain, has stable performance, has good water solubility, and is biodegradable, which can make the present invention The...
Embodiment 1
[0074] Prepare the Aloe vera solution that mass concentration is 0.5% according to the following method:
[0075] Dry the aloe vera flower diameter in an oven at 60°C for 4 hours, and after confirming that there is no moisture in it, put the aloe vera flower diameter in the drying box for later use; put the dried aloe vera flower diameter in a round bottom flask, and pour it into the flask Add distilled water and carry out reflux extraction at 100°C, centrifuge the obtained extract at a speed of 4800r / min for 10min, filter the obtained filtrate through a filter cloth to remove the aloe flowers floating on the surface, and obtain a polysaccharide clear liquid; according to the above technology The method described in the scheme was used to prepare three polysaccharide clear liquids; the polysaccharide clear liquids prepared three times were combined, the residue was washed with distilled water, and then centrifuged, and the centrifuged filtrate was filtered with a 400-mesh filte...
Embodiment 2
[0088] According to the method described in Example 1, an Aloe vera solution with a mass concentration of 0.5% was prepared.
[0089] Weigh 80g of hyaluronic acid and add it to 920g of 4.5% aqueous sodium hydroxide solution to completely dissolve to obtain a mixed solution;
[0090] Add 1.03g of sodium citrate to the mixed solution and stir and mix to obtain the mixture;
[0091] Add 0.08g of BDDE to the mixture and stir the reaction at 50°C for 5 hours to obtain a reaction solution;
[0092] The reaction solution was placed in a vacuum rotary evaporator for rotary evaporation at 35°C to obtain a product with a water content of 50%;
[0093] Dry the product after rotary evaporation in a vacuum oven at 35°C to obtain a dried product;
[0094] Repeatedly washing the dried product with phosphate solution and distilled water to remove sodium hydroxide therein to obtain a washed product with a pH value of 6;
[0095] Dry the obtained washed product in a vacuum oven at 35°C to ob...
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Abstract
Description
Claims
Application Information
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