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Cannabis sailve extract rich in cannabidiol and preparation method of cannabis sailve extract

A cannabidiol and hemp technology, which is applied in the directions of medical preparations, pharmaceutical formulations, and plant raw materials containing active ingredients to achieve the effects of good color, high CBD content and improved extraction efficiency

Active Publication Date: 2016-05-04
山西汉麻生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent adopts subcritical fluid extraction active substance technology has unique advantages, such as low temperature, non-toxic environmental protection, low energy consumption, etc., but this technology has not been tried for CBD extraction at home and abroad

Method used

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  • Cannabis sailve extract rich in cannabidiol and preparation method of cannabis sailve extract
  • Cannabis sailve extract rich in cannabidiol and preparation method of cannabis sailve extract

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preparation example Construction

[0034] 1) Preparation of sample solution

[0035] Accurately weigh 0.1 gram of the extract product, add 5 milliliters of chloroform to dissolve it into a solution, then pass through an organic membrane of 0.22 μm in an ultrasonic bath for 5 minutes, and store the obtained filtrate in a refrigerator for later use.

[0036] 2) Determination of CBD content

[0037]Use AgilentHP-5 column, Agilent7890A type gas chromatograph to measure. The chromatographic conditions are as follows: the carrier gas is helium, and the flow rate is 1.00 ml / min; Hold for 10 minutes; inlet temperature 150°C, detector temperature 300°C, split ratio 5:1; hydrogen flow rate 40 ml / min, air flow rate 400 ml / min; automatic injection, injection volume 4.0 μL. Prepare standard solutions of different concentrations to perform the above operations, and draw a peak area-CBD concentration standard curve. The determination was carried out according to the above method, the injection volume of the sample solution...

Embodiment 1

[0039] Spread the dried hemp mosaic leaves in an oven for dry heat treatment, the temperature is set at 80° C., and the time is 2 hours, and then it is ground with a pulverizer. Get 1.5 kilograms of hemp flower leaves of dry heat treatment, sub-pack with some filter bags, place in the extraction tank of subcritical extraction device, mix the technical grade n-butane in the solvent tank by solid-liquid ratio 1:8 (W / V) Inject into the material tank, extract for 40 minutes at a subcritical state with a temperature of 35°C and an extraction pressure of 0.4 MPa, and repeat the extraction 3 times to obtain a crude extract. The crude extract was dissolved by adding ethanol at a solid-to-liquid ratio of 1:5 (W / V); then placed in a refrigerator at -10°C for winterization for 60 minutes. Then it was transferred to a centrifuge whose temperature was set to -6°C in advance and whose rotation speed was 4500 rpm, and centrifuged for 30 minutes. Activated carbon was added to the supernatant...

Embodiment 2

[0041] Spread the dried hemp mosaic leaves in a general oven for dry heat treatment, the temperature is set at 80° C., and the time is 2 hours. Then grind it with a pulverizer. Take 1.5 kg of dried hemp mosaic leaves, pack them with filter bags, and place them in the extraction tank of the subcritical extraction device. First, measure 95% ethanol and put it into the extraction tank, and then send it into the corresponding volume of n-butane through the flow valve of the equipment. , so that the concentration of ethanol in the solvent tank reaches 20% of n-butane, inject the mixed n-butane solvent into the material tank, and extract for 40 minutes at a subcritical state with a temperature of 40°C and an extraction pressure of 0.4MPa, and an extraction temperature of 55°C , extracted for 40 min, and then desolvated under reduced pressure, the extract was taken out, and the extraction was repeated 3 times. Add a certain amount of ethanol to the ethanol solution containing the ex...

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Abstract

The invention discloses cannabis sailve extract which is extracted from flowers and leaves of industrial cannabis sailve and rich in cannabidiol (CBD) and a preparation method of the cannabis sailve extract. The preparation method includes the steps that firstly, heat dry treatment is conducted on the flowers and leaves of cannabis sailve, then a subcritical butane extraction technology is adopted, ethyl alcohol serves as entrainer, and crude extract which is rich in cannabidiol is obtained; the crude extract is dissolved in an ethanol solution of a certain proportion, and low-temperature odstearynowanie is conducted; centrifugation is conducted through a centrifugal machine, or filtering is conducted through a filtering machine to remove waxiness; activated carbon is added to liquid supernatant, and decolorization and filtration are conducted; finally, filtrate is subjected to rotary evaporation to remove ethyl alcohol, and the cannabis sailve extract rich in CBD can be obtained. The obtained cannabis sailve extract is high in CBD content and good in color and has a good physiological property. The method is simple in process, industrialized application is achieved easily, and development and utilization of high value-added products of Cannabis sailve are promoted.

Description

technical field [0001] The invention relates to a hemp extract, in particular to a hemp extract rich in cannabidiol (CBD) and a preparation method thereof; it belongs to the field of development technology and application technology of hemp, specifically from industrial hemp A hemp extract rich in cannabidiol (CBD) with good physiological and functional properties was prepared from the flowers and leaves of Hemp. Background technique [0002] Hemp, also known as hemp and industrial hemp, is one of the traditional medicinal materials and health food raw materials in my country. The 2002 document of the Ministry of Health included hemp seed in the "list of items that are both medicine and food", which makes the development and utilization of hemp food legally guaranteed. This also makes condition and support provided to the development of hemp plant mosaic. In recent years, with the deepening of people's understanding of hemp and the in-depth research on the strong physiolog...

Claims

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Application Information

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IPC IPC(8): A61K36/60
CPCA61K36/60A61K2236/15A61K2236/17A61K2236/37A61K2236/53
Inventor 朱元庄
Owner 山西汉麻生物科技有限公司
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