Medicine for stopping bleeding and promoting tissue regeneration and preparation method thereof

A drug and muscle-promoting technology, applied in drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of patients with wound infection, can not stimulate the skin to heal quickly, and achieve the effects of easy absorption, rapid healing, and increased production

Inactive Publication Date: 2016-05-04
ZHANGJIAGANG BENCAO SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] Therefore, from the existing literature, it is shown that using white root to make hemostatic material, one method is to crush it after processing and use it directly or mix it with medicine, but the starch in white root is easy to cause wound infection in patients; another method is to use white root It is used after the polysaccharide is refined. During the refining process of the white and polysaccharides, the phenolic substances in the white and medium are removed, so it cannot stimulate the skin around the wound to heal quickly.

Method used

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  • Medicine for stopping bleeding and promoting tissue regeneration and preparation method thereof
  • Medicine for stopping bleeding and promoting tissue regeneration and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0048] Embodiment 1: the preparation method of white and water-soluble polysaccharide

[0049] Crush 100kg of dry white powder, add 1000L of amylase aqueous solution to make the final concentration of amylase above 2U, heat it at 40°C for 4 hours to obtain a hydrolysis mixture; Membrane filtration once to obtain filtrate I and filter residue I; Concentrate filtrate I under reduced pressure at 50-60°C to 1 / 15 of the original volume, then add 95% ethanol until the final concentration reaches more than 80%, alcohol precipitation for 10-20h , filter to obtain filtrate II and filter residue II, and concentrate and crystallize filtrate II to obtain glucose; add neutral protease solution to filter residue II so that the final concentration of neutral protease is above 5U, and after hydrolysis for 30 minutes, keep warm at 80-90°C for 10 minutes , filtered once with a 0.22 μm ceramic membrane to obtain the filtrate III, and then separated the filtrate III on a SEPHADEX G-15 column, and...

Embodiment 1

[0051]According to the preparation process of Baiji polysaccharides introduced by the publication number CN101906169A: pulverize 10 kg of Baiji decoction pieces with a pre-installed 1.2mm sieve, and make all of them pass through the No. 2 sieve to obtain Baiji coarse powder. Put white and coarse powder and 500kg of primary reverse osmosis water together in a mixing tank, and stir for 15 minutes to make the mixture evenly into white and suspension. Input the bletilla suspension into the high-pressure homogenizer, and adjust the pressure of the pump body of the high-pressure homogenizer to 45-55MPa. The high-pressure homogenized homogenate is centrifuged in a three-legged centrifuge to collect the centrifugate. Add 2 kg of talcum powder and 2 kg of diatomaceous earth to the centrifugal liquid, mix well, and circulate and filter through a diatomaceous earth filter until the filtrate is almost colorless and clear, then collect the filtrate. Filter the media filtrate through a mic...

Embodiment 2

[0053] According to the publication number CN103044560A, the preparation method of Baiji polysaccharides is as follows: take 10 kg of Baiji tubers, pulverize them, pass through a 20-mesh sieve, add 2 to 4 times the mass and volume of 70 to 90% ethanol to soak for 4 hours, and drain the ethanol. Then add 10-20 times of raw material quality deionized water for extraction, temperature 60-80°C, stir and extract for 3-4 hours, filter and separate the filter residue, centrifuge the filtrate at 8000r / min for 15min, and the supernatant is concentrated to the original volume by a rotary evaporator 1 / 3 of its volume, add 80-95% ethanol according to its volume 2-4 times, set aside for precipitation at 4-8°C for 8 hours, filter and wash to obtain white and crude polysaccharides, and obtain white and crude polysaccharides after vacuum drying, the concentration of which is 2 ~5%, add papain 1~12mg / g for hydrolysis, the pH of the hydrolysis system is 5.5~8.5, the hydrolysis temperature is 40~...

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Abstract

The invention relates to a rhizoma bletillae medicine for stopping bleeding and promoting tissue regeneration. The medicine is prepared by the following steps: carrying out heating extraction on the dried rhizoma bletillae with distilled water, adding neutral protease to hydrolyze protein, filtering, and concentrating at reduced pressure; adsorbing with columns, concentrating eluent, and concentrating at reduced pressure to prepare a rhizoma bletillae polysaccharide pure product having a polysaccharide content of more than 99 percent; and mixing the rhizoma bletillae polysaccharide with chitosan and callicarpa macrophylla extract, adding water, mixing and freezing until the product is dry. The freeze-dried product can be applied to health-care or medicinal products.

Description

Technical field: [0001] The invention relates to a drug product for hemostasis and muscle growth, in particular to the application of white and water-soluble polysaccharides in the drug for hemostasis and muscle growth, and belongs to the technical field of natural medicine applications. Background technique [0002] The hemostatic effect of Baiji is accurate and reliable, which is related to the large amount of Baiji gum contained in it. Baijijiao film has strong adhesion, and when applied to the bleeding point or surface of animals, it can immediately fuse with the wound and is difficult to peel off, and only melts on the side that touches the wound, so that bleeding can be stopped quickly and infection can be prevented. Experiments have proved that the extract of Baiji can shorten the coagulation time, inhibit the dissolution of cellulose by the body, and can quickly form artificial thrombus. [0003] Ancient medical works record Bai and "the seal is damaged, and the car...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61P7/04A61P17/02A61L15/28A61L15/40A61L15/44A61K8/97A61K8/73A61Q19/00A61Q19/08A61K31/722
CPCA61K8/736A61K8/97A61K31/722A61K36/11A61K36/73A61K36/85A61K36/896A61K36/898A61K2236/19A61K2236/333A61K2236/53A61K2236/55A61L15/28A61L15/40A61L15/44A61L2300/30A61L2300/418A61L2400/04A61Q19/00A61Q19/08A61K2300/00C08L5/08
Inventor 向华唐克华唐忠海
Owner ZHANGJIAGANG BENCAO SCI & TECH
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