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Novel degradable bone implantation material and preparation method thereof

A bone implant, a new type of technology, applied in the field of new degradable bone implants and its preparation, can solve the problems of acidic degradation products and slow degradation rate, and achieve improved biocompatibility, reduced toxicity, and good mechanical properties. performance effect

Active Publication Date: 2016-05-04
NINGBO HICREN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, Chinese patent 201310388513.X discloses an intervertebral fusion device made of poly-DL-lactic acid, poly-L-lactic acid / glycolic acid copolymer, hydroxyapatite and tricalcium phosphate, which has high strength, good Osteoinductive activity, can be completely degraded and absorbed in vivo, but there are still problems such as slow degradation rate and acidic degradation products

Method used

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  • Novel degradable bone implantation material and preparation method thereof
  • Novel degradable bone implantation material and preparation method thereof
  • Novel degradable bone implantation material and preparation method thereof

Examples

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Effect test

Embodiment 1

[0063] figure 1 It is a schematic diagram of the degradable bone filling particles prepared by the present invention, and the specific preparation steps are as follows:

[0064] a. According to the formula ①, the powder and the liquid are mixed and stirred to obtain a paste;

[0065] b. Inject the paste into a φ3x3 mold and keep the injection pressure at 8atm;

[0066] c. Demoulding after the paste is cured to obtain bone filling particles;

[0067] d. Place the bone filling particles in a constant temperature and humidity cabinet with a temperature of 37° C. and a humidity of 60% for 28 hours.

[0068] The prepared degradable bone filling particles can be used for bone defect filling.

Embodiment 2

[0070] figure 2 The structural schematic diagram of the degradable fusion device 1 of the metal frame 2 containing magnesium alloy prepared for the present invention, the specific preparation steps are as follows:

[0071] a. Process the magnesium alloy into a frame and put it into a mold.

[0072] b. According to the formula ②, the powder and the liquid are mixed and stirred to obtain a paste;

[0073] c. Inject the paste into a mold with a magnesium alloy frame and keep the injection pressure at 15atm;

[0074] d. Release the mold after the paste solidifies to obtain a biodegradable fuser;

[0075] e. Place the biodegradable fuser in a constant temperature and humidity cabinet with a temperature of 37° C. and a humidity of 80% for 48 hours.

[0076] The prepared degradable fusion device can be used in various fusion operations.

Embodiment 3

[0078] image 3 The structural schematic diagram of the degradable fusion device 1 containing the metal inner support 3 of the pure magnesium strip prepared for the present invention, the specific preparation steps are as follows:

[0079] a. Process pure magnesium into strips and put them into molds.

[0080] b. According to the formula ③, the powder and the liquid are mixed and stirred to obtain a paste;

[0081] c. Inject the paste into a mold with a pure magnesium rack, and keep the injection pressure at 12atm;

[0082] d. Release the mold after the paste solidifies to obtain a biodegradable fuser;

[0083] e. Place the biodegradable fuser in a constant temperature and humidity cabinet with a temperature of 37° C. and a humidity of 90% for 36 hours.

[0084] The prepared degradable fusion device can be used in various fusion operations.

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Abstract

The invention relates to a novel degradable bone implantation material and a preparation method thereof. The bone implantation material is prepared by mixing and pressurizing powder and liquid and then performing solidification, wherein the powder is prepared from 32-70% by weight of phosphate, 28-65% by weight of metal oxide and 1-15% by weight of a silicon-containing compound, and the liquid-solid ratio of the liquid and the powder is 0.1-0.5 ml / g. The preparation method comprises the following steps that firstly, the powder and the liquid are mixed and stirred according to the ratio of 0.1-0.5 ml / g to obtain paste; secondly, the paste is injected into a mould, the pressure is kept to be greater than or equal to 5 atm; thirdly, after the paste solidifies and is released from the mould, the bone implantation material is obtained; finally, the bone implantation material is put in a constant-temperature constant-humidity cabinet with the temperature of 37 DEG C and the humidity of 50-100% for 24 hours or more. The bone implantation material has the advantages of being high in strength, degradable, absorbable, controllable in degradation rate, high in bony fusion rate and the like.

Description

technical field [0001] The invention relates to the field of medical bone implant instruments, in particular to a novel degradable bone implant and a preparation method thereof. Background technique [0002] Bone implants are required when bone tissue is damaged by fractures, diseases, etc. Bone implants mainly include autologous bone implants, allogeneic bone implants and biomaterial bone implants. The clinical application of the former two is limited because of the limited quantity. At present, bone implants made of biomaterials are commonly used clinically, and such biomaterials include non-degradable and degradable materials. Bone implants made of non-degradable materials such as stainless steel, titanium alloy, PEEK, etc., require secondary surgery to remove because they are not degradable in the body. In addition, metal bone implants are likely to cause problems such as stress shielding. Although the mechanics of PEEK materials are similar to those of bone tissue, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/02A61L27/18A61L27/20A61L27/36A61L27/52A61L27/56A61L27/58
CPCA61L27/02A61L27/12A61L27/18A61L27/20A61L27/36A61L27/52A61L27/56A61L27/58A61L2430/02A61L27/025A61L27/3608A61L27/365A61L2400/18C08L5/08C08L67/04
Inventor 吕世文毛克亚卓清山张鹏云
Owner NINGBO HICREN BIOTECH
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