A multiple liquid-phase construction method for the preparation of calcium phosphate active ceramic bone scaffolds

A technology of active ceramics and calcium phosphate, applied in the field of bone tissue engineering, can solve the problems of insufficient mechanical strength, difficult material sintering, low density, etc., and achieve the effects of improving mechanical properties, promoting extracellular response, and improving biological properties.

Inactive Publication Date: 2019-11-12
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention utilizes K 2 CO 3 、Na 2 CO 3 , Li 2 CO 3 Three materials construct a component that provides a liquid phase at 399°C, 695°C, and 891°C temperature points, which solves the shortcomings of difficult sintering, low density, and insufficient mechanical strength in the process of laser sintering calcium phosphate active ceramic bone scaffolds. And using their pyrolysis properties to obtain the microporous structure required for bone scaffolds

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Weigh 3 grams, 2 grams and 1 gram of potassium carbonate, sodium carbonate and lithium carbonate powder respectively, and weigh 94 grams of hydroxyapatite powder, a total of 100 grams; then put the weighed powder into 900 grams of alcohol to prepare Make a 10% mixed solution, stir it with a magnetic stirrer at a rate of 1200r / min for 2 hours to make it uniform;

[0022] 2. Filter the mixed solution, then place it in a vacuum drying oven, dry it at 70°C for 8 hours, and then pass the dried mixed powder through ball milling for 20 hours to obtain a solid mixed uniform composite powder;

[0023] 3. Load the obtained composite powder into a selective laser auxiliary powder system, and use the sintering parameters such as a laser spot with a diameter of 0.8mm, a laser power of 7W, and a scanning speed of 100mm / min for sintering preparation in a nitrogen atmosphere.

Embodiment 2

[0025] 1. Weigh 1.5g, 1g and 0.5g of potassium carbonate, sodium carbonate and lithium carbonate powder respectively, weigh 97g of tricalcium phosphate powder, a total of 100g; then put the weighed powder into 900g of alcohol to prepare The 10% mixed solution was stirred by a magnetic stirrer at a rate of 1200r / min for 2 hours to make it uniform;

[0026] 2. Filter the mixed solution, then place it in a vacuum drying oven, dry it at 65 °C for 8 hours, and then pass the dried mixed powder through ball milling for 25 hours to obtain a solid-state mixed uniform composite powder;

[0027] 3. Load the obtained composite powder into a selective laser auxiliary powder system, and use the sintering parameters such as a laser spot with a diameter of 1mm, a laser power of 6W, and a scanning speed of 100mm / min to sinter and prepare in a nitrogen atmosphere.

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Abstract

The invention discloses a preparation method of a multiple liquid phase formed by using a formula composed of three materials of K2CO3, Na2CO3 and Li2CO3, and which solves the problems of difficult sintering and low density of the calcium phosphate active ceramic during selective laser sintering. The method comprises the following steps: uniformly mixing K2CO3, Na2CO3 and Li2CO3 according to the mass ratio of 3: 2: 1 to prepare the carbonate powder; weighing the 94-99% of calcium phosphate active ceramic powder and 1-6% of carbonate powder according to mass ratio, uniformly mixing the materials in alcohol through a magnetic stirrer; performing vacuum drying on the stirred powder and performing ball milling on the powder to obtain the composite powder; and performing selective laser sintering on the composite powder for preparing the bone scaffold. The preparation method is simple, the material source is wide, and the prepared bone scaffold has good mechanical property and biological performance.

Description

technical field [0001] The present invention relates to a method utilizing K 2 CO 3 , Na 2 CO 3 and Li 2 CO 3 The formula composed of three materials forms multiple liquid phases, solves the problems of difficult sintering and low density of calcium phosphate active ceramics during selective laser sintering, and at the same time utilizes their decomposition to generate gas to form the method of microporous structure necessary for bone scaffolds, belonging to field of bone tissue engineering. Background technique [0002] The tissue engineering bone scaffold should first have good biocompatibility to ensure the safety of the body, a certain mechanical strength to provide structural support for the defect site, and a suitable microporous structure to facilitate cell growth, differentiation and proliferation. Calcium phosphate active ceramics mainly include hydroxyapatite and tricalcium phosphate, which are important inorganic substances that constitute the hard tissue of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/04A61L27/02A61L27/50A61L27/56
Inventor 帅词俊彭淑平冯佩
Owner CENT SOUTH UNIV
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