A novel degradable bone implant and its preparation method

A bone implant, a new type of technology, used in medical science, prosthesis, tissue regeneration, etc., can solve the problems of slow degradation rate and acidic degradation products, reduce toxicity, improve biocompatibility, and reduce freeness Effect

Active Publication Date: 2019-04-02
NINGBO HICREN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, Chinese patent 201310388513.X discloses an intervertebral fusion device made of poly-DL-lactic acid, poly-L-lactic acid / glycolic acid copolymer, hydroxyapatite and tricalcium phosphate, which has high strength, good Osteoinductive activity, can be completely degraded and absorbed in vivo, but there are still problems such as slow degradation rate and acidic degradation products

Method used

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  • A novel degradable bone implant and its preparation method
  • A novel degradable bone implant and its preparation method
  • A novel degradable bone implant and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] figure 1 It is a schematic diagram of the degradable bone filling particles prepared by the present invention, and the specific preparation steps are as follows:

[0065] a. According to the formula ①, the powder and the liquid are mixed and stirred to obtain a paste;

[0066] b. Inject the paste into a φ3x3 mold and keep the injection pressure at 8atm;

[0067] c. Demoulding after the paste is cured to obtain bone filling particles;

[0068] d. Place the bone filling particles in a constant temperature and humidity cabinet with a temperature of 37° C. and a humidity of 60% for 28 hours.

[0069] The prepared degradable bone filling particles can be used for bone defect filling.

Embodiment 2

[0071] figure 2 The structural schematic diagram of the degradable fusion device 1 of the metal frame 2 containing magnesium alloy prepared for the present invention, the specific preparation steps are as follows:

[0072] a. Process the magnesium alloy into a frame and put it into a mold.

[0073] b. According to the formula ②, the powder and the liquid are mixed and stirred to obtain a paste;

[0074] c. Inject the paste into a mold with a magnesium alloy frame and keep the injection pressure at 15atm;

[0075] d. Release the mold after the paste solidifies to obtain a biodegradable fuser;

[0076] e. Place the biodegradable fuser in a constant temperature and humidity cabinet with a temperature of 37° C. and a humidity of 80% for 48 hours.

[0077] The prepared degradable fusion device can be used in various fusion operations.

Embodiment 3

[0079] image 3 The structural schematic diagram of the degradable fusion device 1 containing the metal inner support 3 of the pure magnesium strip prepared for the present invention, the specific preparation steps are as follows:

[0080] a. Process pure magnesium into strips and put them into molds.

[0081] b. According to the formula ③, the powder and the liquid are mixed and stirred to obtain a paste;

[0082] c. Inject the paste into a mold with a pure magnesium rack, and keep the injection pressure at 12atm;

[0083] d. Release the mold after the paste solidifies to obtain a biodegradable fuser;

[0084] e. Place the biodegradable fuser in a constant temperature and humidity cabinet with a temperature of 37° C. and a humidity of 90% for 36 hours.

[0085] The prepared degradable fusion device can be used in various fusion operations.

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Abstract

A degradable bone implant, and manufacturing method thereof. The bone implant is manufactured by mixing a powder agent and a liquid agent, applying a pressure, and curing. The powder agent is formed by the following components: 32-70 wt% of a phosphate, 28-65 wt% of a metal oxide, and 1-15 wt% of a silicon-containing compound, and a liquid-to-solid ratio of the liquid agent and the powder agent is 0.1-0.5 ml / g. The manufacturing method comprises the following steps: first, mixing the powder agent and the liquid agent according to proportions to obtain a paste; next, pouring the paste into a mold, and holding the pressure at no less than 5 atmospheres; then, after the paste is cured, demolding to obtain a bone implant; and finally, placing the bone implant in a temperature-humidity chamber at a temperature of 37°C and a humidity of 50-100% for not less than 24 hours. The bone implant has the advantages of high strength, degradability, a controllable degrading rate, and superior osseous fusion.

Description

technical field [0001] The invention relates to the field of medical bone implant instruments, in particular to a novel degradable bone implant and a preparation method thereof. Background technique [0002] Bone implants are required when bone tissue is damaged by fractures, diseases, etc. Bone implants mainly include autologous bone implants, allogeneic bone implants and biomaterial bone implants. The clinical application of the former two is limited because of the limited quantity. At present, bone implants made of biomaterials are commonly used clinically, and such biomaterials include non-degradable and degradable materials. Bone implants made of non-degradable materials such as stainless steel, titanium alloy, PEEK, etc., require secondary surgery to remove because they are not degradable in the body. In addition, metal bone implants are likely to cause problems such as stress shielding. Although the mechanics of PEEK materials are similar to those of bone tissue, t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/02A61L27/18A61L27/20A61L27/36A61L27/52A61L27/56A61L27/58
CPCA61L27/02A61L27/12A61L27/18A61L27/20A61L27/36A61L27/52A61L27/56A61L27/58A61L2430/02
Inventor 吕世文毛克亚卓清山张鹏云
Owner NINGBO HICREN BIOTECH
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