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Multiple liquid-phase construction method of calcium phosphate active ceramic bone scaffold

A technology of active ceramics and calcium phosphate, applied in the field of bone tissue engineering, can solve the problems of difficult sintering, low density, and insufficient mechanical strength of materials, and achieve the effects of improving mechanical properties, promoting extracellular response, and improving biological properties

Inactive Publication Date: 2017-01-18
CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention utilizes K 2 CO 3 、Na 2 CO 3 , Li 2 CO 3 Three materials construct a component that provides a liquid phase at 399°C, 695°C, and 891°C temperature points, which solves the shortcomings of difficult sintering, low density, and insufficient mechanical strength in the process of laser sintering calcium phosphate active ceramic bone scaffolds. And using their pyrolysis properties to obtain the microporous structure required for bone scaffolds

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Weigh 3 grams, 2 grams and 1 gram of potassium carbonate, sodium carbonate and lithium carbonate powder respectively, and weigh 94 grams of hydroxyapatite powder, 100 grams in total; then put the weighed powder into 900 grams of alcohol to configure into a 10% mixed solution, stirred at a rate of 1200r / min for 2 hours by a magnetic stirrer to make it uniform;

[0022] 2. Filter the mixed solution, then place it in a vacuum drying oven, and dry it at 70°C for 8 hours. The dried mixed powder is then ball milled for 20 hours to obtain a solid and uniformly mixed composite powder;

[0023] 3. Put the obtained composite powder into a selective laser auxiliary powder system, and prepare it by sintering under a nitrogen atmosphere using a laser spot with a diameter of 0.8mm, a laser power of 7W, and a scanning speed of 100mm / min.

Embodiment 2

[0025] 1. Weigh 1.5 grams, 1 gram and 0.5 grams of potassium carbonate, sodium carbonate and lithium carbonate powder respectively, and take 97 grams of tricalcium phosphate powder, 100 grams in total; then put the weighed powder into 900 grams of alcohol to configure 10% of the mixed solution was stirred by a magnetic stirrer at a rate of 1200r / min for 2 hours to make it uniform;

[0026] 2. Filter the mixed liquid, then place it in a vacuum drying oven, and dry it at 65°C for 8 hours. The dried mixed powder is then ball milled for 25 hours to obtain a solid and uniformly mixed composite powder;

[0027] 3. Put the obtained composite powder into a selective laser auxiliary powder system, and prepare it by sintering under a nitrogen atmosphere using a laser spot with a diameter of 1mm, a laser power of 6W, and a scanning speed of 100mm / min.

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Abstract

The invention discloses a preparation method of a multiple liquid phase formed by using a formula composed of three materials of K2CO3, Na2CO3 and Li2CO3, and which solves the problems of difficult sintering and low density of the calcium phosphate active ceramic during selective laser sintering. The method comprises the following steps: uniformly mixing K2CO3, Na2CO3 and Li2CO3 according to the mass ratio of 3: 2: 1 to prepare the carbonate powder; weighing the 94-99% of calcium phosphate active ceramic powder and 1-6% of carbonate powder according to mass ratio, uniformly mixing the materials in alcohol through a magnetic stirrer; performing vacuum drying on the stirred powder and performing ball milling on the powder to obtain the composite powder; and performing selective laser sintering on the composite powder for preparing the bone scaffold. The preparation method is simple, the material source is wide, and the prepared bone scaffold has good mechanical property and biological performance.

Description

technical field [0001] The present invention relates to a method using K 2 CO 3 、Na 2 CO 3 and Li 2 CO 3 The formula composed of three materials forms multiple liquid phases, which solves the problems of difficult sintering and low density of calcium phosphate active ceramics during selective laser sintering, and at the same time uses their decomposition to generate gas to form the microporous structure necessary for bone scaffolding. field of bone tissue engineering. Background technique [0002] Tissue engineered bone scaffolds should first have good biocompatibility to ensure the safety of the body, a certain mechanical strength to provide structural support for the defect site, and a suitable microporous structure to facilitate cell growth, differentiation and proliferation. Calcium phosphate active ceramics mainly include hydroxyapatite and tricalcium phosphate, which are important inorganic substances that constitute the hard tissue of the human body. After being...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/04A61L27/02A61L27/50A61L27/56
Inventor 帅词俊彭淑平冯佩
Owner CENT SOUTH UNIV
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